Effective implementation of Good Manufacturing Practices (GMP) is critical to ensure consistent quality and safety of any pharmaceutical product. GMP guidelines are minimum requirements that cell and gene therapy producers must meet. Due to multiple ways to comply, there is always a level of uncertainty for applying only the most correct and reasonable measures. The enormous task of implementing all GMP elements correctly is especially challenging for newly upcoming cell therapy institutions. The process can be extremely confusing, especially for new equipment acquisition. What are the critical attributes you should look for in GMP compatible equipment? How can you align your choices of equipment with the key GMP principles? What are the correct steps to be taken in the process of equipment acquisition for the GMP lab?