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Our latest research innovations in immune repertoire profiling, microsatellite instability, and tumor mutation burden were recently highlighted at the Society for Immunotherapy of Cancer annual meeting (SITC 2019). Fill out the form to download our posters from SITC 2019 and learn how advances in NGS can take your immuno-oncology research to the next level.

Elevated TCRB repertoire convergence and clonal expansion in the NSCLC tumor microenvironment of responders to anti-PD-1 monotherapy

• Investigated the predictive value of TCRB evenness and convergence for NSCLC
• Compared these features with tumor mutation

burden and PD-L1 IHC values from the same tumors

Automated rarefaction analysis for precision human and mouse B and T cell receptor repertoire profiling from peripheral blood and FFPE-preserved specimens

• Identifying the optimal input amount and sequencing depth for repertoire profiling is challenging

• Presented a novel method for saturation analysis of IGH and TCRB chain libraries

Evaluation of a tumor-only pan-cancer targeted semi-conductor based next-generation sequencing (NGS) test for microsatellite instability in FFPE samples

• NGS has become an essential tool to support routine clinical research in oncology
• Developed a novel algorithm to provide results for microsatellites and generate a total MSI score,

without requiring matching normal tissue

Development of a pan-cancer NGS assay for detection of tumor mutational burden and targeted biomarkers from FFPE samples

• Automated sample to report workflow for cancer biomarkers, including TMB

• Sensitivity and specificity to accommodate low quantity FFPE tissues

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The comprehensive Ion Torrent portfolio of immuno-oncology next-generation sequencing (NGS) solutions enable a multi-dimensional approach to understanding the cancer-immunity cycle and tumor microenvironment.

Learn more about the Ion Torrent Portfolio for Immuno-oncology research ›