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Register for the Thermo Fisher Scientific commercial tutorials

Complete the form to register your interest for these tutorials presented during CYTO 2019, Vancouver, Canada.

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Tumor-Specific CD8 T Cell Identification, Expansion, and Clinical Research Implications

Presenter: Colin Thalhofer, PhD, Research Scientist, AgonOx, Inc.
Date: Sunday, June 23, 2019
Time: 12:30–1:30 p.m.

Abstract: Through flow cytometry analysis, cell sorting and in vitro techniques, AgonOx has developed a workflow for detecting, isolating and expanding endogenous tumor antigen-specific CD8 T cells from individuals own tumor tissue (Duhen, et al, Nature Communications, volume 9, Article number: 2724 (2018)). The highly enriched tumor-reactive T cells are grown in vitro with a method optimized to achieve large cellular expansion and to maintain a broad repertoire of tumor-reactive T cell clones. The expanded T cell product typically retains much of its original T cell clonal diversity and preserves or reinvigorates its tumor-lytic potential. This platform yields a uniquely personalized subject-derived product for individuals from a wide variety of tumor types. This tumor-specific T cell product is specific/personalized for each subject and has clinical research applications in the immune oncology field.

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Novel Fluorescent Probes and Labeling Strategies for Flow and Imaging Applications

Presenter: Jolene A. Bradford, MLS, SCYM(ASCP)TM, Associate Director, Thermo Fisher Scientific, Eugene, Oregon USA
Date: Monday, June 24, 2019
Time: 12:30–1:30 p.m.

Abstract: We’ve developed a number of novel Invitrogen reagents and assays designed to accelerate the ability to characterize cell health and function. This seminar will present recently developed assays for the detection of hypoxia, senescence, and apoptosis with use in both flow cytometry and imaging-based applications. Over the past decade, biologics have been increasingly pursued as therapeutic agents. In the case of antibody–drug conjugates (ADCs), internalization of the antibody is a powerful mechanism of action. Internalization moves the ADC from its binding site at the plasma membrane of the target cell to the lytic environment of the lysosome, resulting in activation of the attached toxin. With the A to Z of antibody labeling strategies presented as background, antibody labeling tools to measure internalization efficiency will be highlighted. For research use only. Not for use in diagnostic procedures.

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