Circulating miRNAs in serum and plasma have shown potential in biomarker discovery and diagnostic screening. Serum and plasma are easier and less invasive to collect than traditional tissue biopsies. These "liquid biopsy" samples and their circulating miRNAs can provide a sensitive method to discover and monitor diseases.
Due to the potential for variability, several factors must be considered when studying miRNA from serum or plasma. These factors include:
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