ICS 4000 HPIC

Making capillary IC available for the first time

Capillary IC was made possible with the introduction of the world’s first commercially available capillary high pressure ion chromatography systems and columns. While high pressure ion systems provide a new and impressive combination of resolution, speed, sensitivity, reproducibility, and simplicity, the HPIC capillary system is always on and walk-up ready with advantages that may not be apparent at first glance.

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Why was capillary IC developed?

We developed capillary ion chromatography to address customer challenges and provide:

  • Improved productivity; faster time to results
  • High performance with ease of use
  • Reduced reagent and consumable costs
  • Precious, small sample volume capabilities
  • Reliable data with limited sample volumes
Featured capillary IC webinar
High-Pressure Ion Chromatography: Capillary Scale Applications

High-Pressure Ion Chromatography-Capillary Scale Applications

A talk on the advantages of HPIC systems and columns: instrumentation, new technology, and applications at Philips 66.


What is the difference between standard bore and capillary IC?

In capillary IC, the column size, injection volumes, and flow rates are scaled down by a factor of 25 to 100.

  Standard Bore IC Capillary IC
Column ID 4mm 0.4mm
Typical Flow Rate 1.0–1.5mL/min 0.010–0.03μL/min
Injection Volume 40μL 0.4μL
Eluent Consumption/ Waste Generated 43.2L/month 0.432L/month

What are the advantages of an “RFIC” and “Always On” capillary system?

Nothing comes close to the ease of use, reproducibility, and performance of a Thermo Scientific™ Dionex™ RFIC™ system, which automates eluent generation. The combination of RFIC and an instrument that’s always on provides the following additional benefits:

  • Eluent Generator Cartridge (EGC) lasts for 18 months
  • Eliminates eluent preparation by using only 15mL water/day (5.2L water/year)
  • Eliminates variations associated with eluent preparation
  • Provides a stable background with more consistent response
  • Eliminates start-up and equilibration time
  • Reduces the need for repeated calibrations; verifies system performance by running a check standard
  • Provides highly reproducible results, with little variability in peak retention times or areas
  • Reduces preventive maintenance and down time because it uses only water

How does capillary IC reduce costs?

  • Eluent generator cartridges (EGCs) last 18 months
  • Reduces waste disposal from 520L to 5.2L per year
  • Saves time by eliminating eluent preparation, start-up time, and system equilibration
  • Reduces preventive maintenance and down time because it uses only water

How does capillary IC affect mass sensitivity?

Mass sensitivity is improved 100-fold by scaling the diameter of the column to 0.4mm.

Read more ›


What Dionex capillary ion chromatography systems are available?

Dionex ICS-4000 Capillary HPIC System Perform high-resolution ion chromatography quickly and at less cost in an integrated, plug-and-play high pressure system
Dionex ICS-5000+ Capillary HPIC System Get best-in-class resolution, speed, and sensitivity while saving time and eluent with this highly customizable, modular, high pressure system. Available in single, dual and hybrid (capillary and 2/4mm) configurations

Both of our capillary systems are high pressure ion chromatography (HPIC) systems. Adding to the advantages inherent in capillary IC is the ability to continuously operate at pressures up to 5000 psi. This allows you to take advantage of new high-efficiency 4μm particle-size columns for even better performance. HPIC systems in capillary format deliver an impressive combination of advantages—resolution, speed, sensitivity, reproducibility, and simplicity.

Featured Dionex IC system videos

What are some applications that can take advantage of capillary IC?

  • Drinking water
  • Wastewater
  • Mono- & disaccharides
  • Ions in juices
  • Counter ion analysis
  • Ultrapure water

What Dionex capillary IC columns are available?

We offer carbohydrate, cation, anion carbonate, and anion hydroxide IC columns in capillary format.

Capillary IC Columns Application For Matrices
Dionex IonPac AS28-4µm Fast, high-resolution separation of trace concentrations of low molecular weight organic acids (glycolate, acetate) and inorganic anions Ultrapure water
Dionex IonPac AS19-4µm High-resolution separation of oxyhalides and inorganic anions In complex sample matrices
Dionex IonPac AS11-HC-4µm High-resolution separation of organic acids and inorganic anions In complex sample matrices
Dionex IonPac AS18-4µm Fast, high-resolution separation of inorganic anions In diverse matrices
Dionex IonPac AS27 Best column for trace bromate in drinking water preserved with ethylenediamine (EDA) In drinking water preserved with ethylenediamine (EDA)
Dionex IonPac AS26 Analysis of HAAs in drinking water by 2D-IC In drinking water
Dionex IonPac AS25 Best column for multivalent anions and polarizable anions In complex matrices
Dionex IonPac AS20 Trace perchlorate analysis Environmental water samples with high chloride, sulfate, or carbonate
Dionex IonPac AS24A Analysis of HAAS by 2D-IC In drinking water
Dionex IonPac AS23 Separation of oxyhalides and inorganic anions using a carbonate based eluent In complex matrices
Dionex IonPac AS22 Separation of inorganic anions using a carbonate based eluent In complex matrices
Dionex IonPac AS9-HC Separation of oxyhalides and inorganic anions using a carbonate based eluent In complex matrices
Dionex IonPac AS19 Inorganic anions, oxyhalides and trace bromate In drinking water and diverse matrices
Dionex IonPac AS18 Best column for standard anions and low molecular weight organic acids In diverse sample matrices
Dionex IonPac AS16 Trace perchlorate analysis. Capillary column used in 2D-IC method for perchlorate In environmental samples
Dionex IonPac AS15 Best column for trace anions and low molecular weight organic acids In high-purity water
Dionex IonPac AS11-HC High capacity column for separation of organic acids and inorganic anions In complex sample matrices
Dionex IonPac CS20 Group I and Group II cations, and amines including methylamines, ethylamines, ethanolamines, and alkanolamines In complex matrices
Dionex IonPac CS19-4µm Fast, high-resolution separation of cations and small polar amines In diverse matrices
Dionex IonPac CS19 Best column for common cations, ammonium and small polar amines In diverse matrices
Dionex IonPac CS17 Polyvalent and moderately hydrophobic amines, including diamines and biogenic amines In diverse sample matrices
Dionex IonPac CS16-4µm High resolution of short chain amines and disparate ratios of sodium and ammonium In diverse matrices
Dionex IonPac CS16 Short chain amines and disparate ratios of sodium and ammonium In complex matrices
Dionex IonPac CS12A-8µm Fast separations of mono and divalent cations, morpholine, alkylamines, aromatic amines and quaternary ammonium ions In various matrices
Dionex CarboPac PA20 High-resolution separations of mono- and disaccharides without derivatization, including optimized resolution of glucosamine/galactose and glucose/ mannose peak pairs In foods, beverages, glycoprotein therapeutics, and mammalian glycoproteins
Dionex CarboPac PA10 Separation of mono- and disaccharides as well as quantification of amino, neutral, and acidic monosaccharides without derivatization In foods, drugs, plants, and mammalian glycoproteins
Fast IC Capillary Columns Application Matrices
Dionex IonPac AS28-4µm Fast, high-resolution of trace concentrations of low molecular weight organic acids (glycolate, acetate) and inorganic anions Ultrapure water
Dionex IonPac AS18-4µm Fast, high-resolution separation of inorganic anions In diverse matrices
Dionex IonPac AS22-Fast Recommended carbonate column for fast analysis of common inorganic anions In simple matrices
Dionex IonPac AS22-Fast-4µm Fast high resolution separation of common inorganic anions In simple matrices
Dionex IonPac CS16-Fast-4µm Fast, high resolution of short chain amines and disparate ratios of sodium and ammonium In diverse matrices
Dionex IonPac CS12A-5µm Mono and divalent cations, morpholine, alkylamines, aromatic amines and quaternary ammonium ions In various matrices

Chromeleon CDS Software Resources

Here’s a collection of resources to learn about the feature sets that make this software both powerful and easy to use.

Resources

Literature

Videos

 Thermo Scientific Dionex ICS-4000 HPIC
 2013 R&D Magazine 100 Award Winner: Dionex ICS-4000 HPIC System