Biopharmaceutical Analysis by Vanquish HPLC/UHPLC

Built for biopharma

Development of complex protein-based therapeutics places rigorous demands on analytical technologies. To fully characterize biotherapeutic proteins, you need an HPLC system that was developed to meet the demanding analytical challenges that these complex molecules require.

Because of their innovative architecture, Thermo Scientific Vanquish UHPLC systems were engineered to build your drug pipeline, catering specifically for the demanding analytical requirements that these molecules impose.

Biopharmaceutical analysis resource categories

Protein aggregate analyses
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These resources describe solutions for protein aggregation detection that are rapid and reliable, giving you confidence in your ability to identify and separate higher order structures.

Even small changes in the type, composition, or linkage of attached glycans can alter biotherapeutic efficacy. Learn why Vanquish HPLC/UHPLC solutions provide an advantage for your released, labelled, and non-labelled glycan analyses.

Charge variant analyses
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Protein charge homogeneity can affect the structure, stability, binding affinity, and efficacy of a biotherapeutic drug. Learn about our full solution for ion exchange chromatography (IEX) for protein charge variant profiling with salt gradient or pH gradient elution.

Peptide mapping analyses
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Complex protein digests require high peak capacity and high-resolution separations. Learn about Vanquish UHPLC systems provide peptide mapping workflow solutions for fast, reproducible protein digestion, and powerful yet simple peptide mapping software.

Intact mass analysis
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Comprehensive characterization of biotherapeutics is necessary to ensure protein drug efficacy. Learn about the benefits of using liquid chromatography (LC) and mass spectrometry (MS), and how high resolution accurate mass (HRAM) instrumentation can enhance your intact protein analysis.

Vanquish UHPLC videos

Vanquish biopharma customer testimonials