Dionex Inuvion IC System: Ultra-reliable, day-to-day ion analysis

Perform ion analysis with the Thermo Scientific Dionex Inuvion IC System, an intuitive, ultra-reliable ion chromatography (IC) instrument with straightforward operation and extended application capabilities. This system supports electrolytic suppression and can include Reagent-Free IC (RFIC) eluent generation for additional time-savings, greater day-to-day consistency, and gradients to optimize methods. It offers automated start-up and shut-down routines to save time and consistently reliable performance for busy analytical testing laboratories.


Flexible, adaptable platform

The Dionex Inuvion IC System is designed to help your lab meet the needs of today and the future. Upgrade the Dionex Inuvion IC System to include RFIC for automated eluent generation capabilities. Optional accessories can be swapped in and out of the instrument by users in less than five minutes for extended application capabilities.

Ultra-reliable performance

This state-of-the-art ion chromatography system is engineered for maximum productivity. With new pump technology and electronics, the Dionex Inuvion IC System provides enhanced day-to-day reliability. System self-diagnostics also detect any issues with hardware and consumables, giving you the confidence that it will be ready to run whenever you are.

Easy-to-use platform

The Dionex Inuvion IC System is designed for fast startup and maximum uptime. With convenient, unobstructed access to all necessary components and a logical flow path, users can quickly and safely access everything on the instrument.

Suppression compatibility

The Dionex Inuvion IC System offers the choice of using either chemical suppression, for more challenging samples, or electrolytic suppression, for ease of use and convenience. Suppressors remove conductive ions from the eluent to decrease background conductivity, while enhancing analyte signal, enabling high sensitivity to achieve low detection limits with conductivity detection.

High-pressure operation

With the ability to operate at up to 5,000 psi, the Dionex Inuvion IC System can take advantage of high-performance 4 µm-particle-size Thermo Scientific Dionex IC columns for more efficient separations that can be used to shorten run times.

Chromatography data system

The Dionex Inuvion IC System comes with the easy-to-use Thermo Scientific Chromeleon Chromatography Data System (CDS). This CDS platform automates and optimizes daily tasks and helps even inexperienced users achieve consistent, high-quality results.


System specifications

The table below provides an overview of the Dionex Inuvion IC System specifications. Not all specifications are listed. For a full list of the specifications, download the Dionex Inuvion IC System specifications sheet.


Dionex Inuvion IC System

Analytical pump and fluidics


Serial dual-reciprocating pistons, microprocessor-controlled constant stroke, variable speed


Chemically inert, metal-free PEEK pump heads and flow paths compatible with aqueous eluents of pH 0–14 and reversed-phase solvents

Pump operating pressure

0–35 MPa (0–5000 psi)

Flow rate range

0.00–5.00 mL/min in 0.01 mL/min increments

Flow precision

<0.1%, typically

Flow accuracy

<0.1%, typically

Pressure ripple


Eluent on-off valve


Leak sensor

Optical, standard

Piston seal wash (optional)

Pump head wash can be operated in continuous or intermittent mode when connected to rinse solution supply

Pressure alarm limits

Upper and lower limit pressure alarms can be set

Vacuum degas

Standard, user adjustable vacuum level

Eluent bottles

Standard 2 L polypropylene bottle; allows various sizes

Eluent bottle pressure regulator (optional)

Supported by digital controlled regulator with display

Injection valve

6-port, 2-position Rheodyne valve, electronically activated

Columns supported

2, 3, 4, and 5 mm ID; maximum length 250 mm analytical column with 50 mm guard column

Eluent generator (RFIC configuration)

Eluent types

KOH, MSA, or K2CO3

Eluent concentration range

0.1-100 mM

Flow rates

0.10–3.00 mL/min when a Thermo Scientific Dionex EGC is installed

Maximum operating pressure

Dionex EGC cartridges: 35 MPa (5000 psi)

Gradient profiles

Up to 9 time-defined gradient steps

Column heater (optional)

Operating temperature range

10 to 60 °C (50 to 140 °F); settable within the software; minimum working range is 5 °C above ambient temperature

Temperature accuracy

±0.5 °C at sensor, at calibration points (35, 45 °C)

Suppressors and control

Chemical and electrolytic suppression

2 mm and 4 mm anion and cation suppressor types

Suppressor regeneration mode

Electrolytic suppressor – Recycle or external water mode
Chemical suppressor – External regenerant

Current control range

Thermo Scientific Dionex DRS 600 Electrolytically Regenerated Suppressor: 0–500 mA (4 mm) and 0–150 mA (2 mm) in 1 mA increments
Thermo Scientific Dionex ERD 500 Electrolytically Regenerated Desalter: 0–500 mA (4 mm) and 0–150 mA (2 mm) in 1 mA increments

Salt converter

Thermo Scientific Dionex SC-CERS 500 available in 2 and 4 mm versions

Carbonic acid removal for anions

Thermo Scientific Dionex CRD 200 Carbonate Removal Device for use with hydroxide eluents or Dionex CRD 300 for use with carbonate eluents

Non-suppressed chromatography

Yes, supported

Suppressor wear parts

Chemical suppression: optional regenerant pump
Electrolytic suppression: none

Dynamic suppression capacity


  • Thermo Scientific Dionex ADRS 600 (4 mm): 200 μeq/min
  • Dionex ADRS 600 (2 mm): 50 μeq/min
  • Thermo Scientific Dionex AERS 500e (4 mm): 200 μeq/min
  • Dionex AERS 500e (2 mm): 50 μeq/min
  • Thermo Scientific Dionex AERS 500 Carbonate (4 mm): 30 μeq/min
  • Dionex AERS 500 Carbonate (2 mm): 7.5 μeq/min
  • Thermo Scientific Dionex ACRS 500 (4 mm): 150 μeq/min
  • Dionex ACRS 500 (2 mm): 75 μeq/min


  • Thermo Scientific Dionex CDRS 600 (4 mm): 100 μeq/min
  • Dionex CDRS 600 (2 mm): 35 μeq/min
  • Thermo Scientific Dionex CERS 500e (4 mm): 100 μeq/min
  • Dionex CERS 500e (2 mm): 35 μeq/min
  • Thermo Scientific Dionex CCRS 500 (4 mm): 75 μeq/min
  • Dionex CCRS 500 (2 mm): 37.5 μeq/min

Void volumes

  • <50 μL for 4mm Dionex DRS 600, ERS 500e, ERS 500 Carbonate, and CRS 500 suppressors
  • <15 μL for 2mm Dionex DRS 600, ERS 500e, ERS 500 Carbonate, and CRS 500 suppressors

Conductivity detector electronics and flow cell


Microprocessor-controlled digital signal processor

Cell drive

128 kHz square wave




0.002 nS/cm

Full-scale output ranges

Digital input signal range 0-18,000 μS/cm, with auto-ranging; analog output signal range 0-18,000 μS/cm

Temperature compensation

Variable, default set at 1.7%/°C at cell temperature

Temperature range

Ambient +7 °C, 30 to 60 °C

Cell electrodes

Passivated 316 stainless steel; compatible with MSA

Cell body

Chemically inert polymeric material

Cell volume

<1 µL

Heat exchanger

Inert, tortuous path for low axial dispersion

Maximum cell operating pressure

10 MPa (1,500 psi)

Data filter

Rise times from 0 to 10 s, Data Collection Rate 1 to 100 Hz, user selectable


Automation using autosampler

For more information about available autosamplers, visit IC Autosamplers

System software


Chromeleon CDS, requires Microsoft® Windows® 10 or 11

Physical specifications

Dimensions (h × w × d)

66.1 x 29.2 x 43.2 cm (26.0 x 11.5 x 17.0 in.)


16.2 kg (36 lb)

Power requirements

100–240 V AC, 50–60 Hz autoranging

Operating temperature

4–40 °C (40–104 °F)

Operating humidity range

20-80% relative, non-condensing

Control modes

Full control through Chromeleon CDS software; alternative control through TTL or relay closures; one relay output, two TTL outputs, two assignable TTL inputs

USB communication protocol

One USB input; three USB outputs

Ordering information


Optional accessories