Sensitive, selective detection of oxidizable compounds
Nothing beats electrochemical detection in HPLC for sensitive, selective measurement of compounds in complex matrices that undergo oxidation or reduction. This detector is ideal for neurotransmitters and pharmaceutical applications where selectivity is needed for characterization in complex samples such as natural products, biological tissues, and fluids. Use amperometric cells for high sensitivity, low sample volumes, and coulometric sensors to maximize both selectivity and sensitivity.
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This bibliography showcases the analytical capabilities of HPLC with electrochemical detection and highlights the scope of different analytical methods found in the literature.
Achieve the lowest possible detection limits for oxidizable and reducible compounds.
- Easy, direct measurement to femtogram levels in very limited sample volumes with minimal preparation.
- Readily eliminates matrix interferences to enhance selectivity.
- Choice of coulometric and amperometric sensors
- The only electrochemical detector compatible with gradient chromatography
Create a profile of multiple trace components in complex matrixes, even in the presence of co-eluting molecules. This gradient-compatible detector allows you to measure multiple—even unresolved—analytes simultaneously.
- Perform targeted analyses or to generate multi-compound patterns
- Resolves co-eluting peaks, determines purity, simplifies sample prep, and measures multiple analytes per sample.
At times the preferred HPLC approach for the sensitive and selective determination of analytes in complex biological matrices can only be achieved using an electrochemical detector.
