Vanquish UHPLC Systems
Separate your science from the status quo
Thermo Scientific Vanquish UHPLC systems are the most advanced UHPLC instruments available. The new Vanquish platform was designed from the ground up to improve performance and repeatability with no trade-offs in quality, robustness, or ease of use. Vanquish platform users have all they need to solve their toughest analytical challenges with confidence.
Advanced UHPLC systems for solving tough analytical challenges
For any application—whether HPLC or UHPLC, small or large molecules, simple or complex mixtures—the Vanquish platform was designed to handle it all. This innovative, simple-to-operate, and easy-to-maintain platform delivers confident separations that push chromatographic boundaries. Regardless of the configuration you choose, you will get a highly integrated solution with optimal fluidic connections, providing unsurpassed retention time and peak area precision.
You will also benefit from the industry-leading, easy-to-use Thermo Scientific Chromeleon Chromatography Data System (CDS) software with eWorkflow method setup, dedicated ePanels, and smart tools. Chromeleon CDS software delivers advanced system communication with single-point intelligent control and functionality. It also provides direct plugins for the Vanquish system to other manufacturers' chromatography data systems.
Choose from two Vanquish UHPLC systems:
For your most complex and difficult samples, or for applications where you are aiming for the shortest cycle times and highest throughput. Vanquish Horizon allows for smaller particles and column dimensions to be run with greater confidence for the most demanding LC and LC-MS workflows.
For assays that require more flexibility in solvents to accommodate all applications. Vanquish Flex excels from method development to routine analyses. With binary and quaternary pump options, the Vanquish Flex offers outstanding performance for targeted LC and LC-MS workflows.
Vanquish Horizon |
Vanquish Flex |
Vanquish Flex |
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| Most advanced UHPLC with revolutionary flow delivery | High pressure binary solvent blending for fast, reliable UHPLC | Quaternary solvent blending for flexible method development | ||
Performance |
System pressure |  Up to 1500 bar |
 Up to 1000 bar |
Up to 1000 bar |
| Retention time precision | |
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| Flow range | 5 mL/min |
8 mL/min |
8 mL/min |
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| Biocompatibility | ||||
System Features |
Design | Modular | Modular | Modular |
| SmartInject technology for best retention time precision | ||||
| SmartFlow technology for excellent flow precision | ||||
| Pump | High-pressure gradient proportioning | High-pressure gradient proportioning | Low-pressure gradient formation | |
| Active solvent pre-heating |
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| Multi-mode column thermostatting | ||||
| Sample cooling | ||||
| Viper fittings for virtually zero dead volume system connections | ||||
| Thermo Scientific Viper UHPLC Fittings Kits Order all the UHPLC fittings and capillaries you need for your system or application in a single kit |
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System components |
Pump | Vanquish Binary Pump H The pump with the highest backpressure at 1500 bar; ideal for shallow gradient performance |
Vanquish Binary Pump F UHPLC performance for demanding routine applications up to 1000 bar |
Vanquish Quaternary Pump F UHPLC performance with more solvent flexibility up to 1000 bar |
| Autosampler | Vanquish Split Sampler HT Excellent precision, accuracy, and short cycle times with innovative air-stream cooling and barcode reading for inventory management for all workflows up to 1500 bar |
Vanquish Split Sampler FT Enjoy the same benefits as the Vanquish Split Sampler HT for applications up to 1000 bar |
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| Column compartment | Vanquish Column Compartment H Provides two column thermostatting modes (still and forced air), active and passive solvent pre-heating and post column cooling for optimized control of your separations and advanced method transfer. |
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| Extended sample capacity | Vanquish Charger An intelligent, robotic rack and plate feeder that automatically loads samples in the autosampler and extends the sample capacity of all Vanquish samplers to up to 8832 samples (23 wellplates or 12 vial racks) with innovative air-stream cooling and barcode reading for inventory management. |
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Compatible components for all Vanquish UHPLC systems
| Detector options | Vanquish columns | Chromeleon CDS software |
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Take advantage of the system's extended pressure capabilities and robustness by using columns that were developed for Vanquish, allowing you to separate your science better, faster, and easier than ever before.
Vanquish can be used with any of our HPLC and UHPLC columns |
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Interact with Vanquish
Take a virtual tour of the Vanquish Horizon, and see how each module's advanced technology will separate your science from the status quo.
Featured Vanquish webinar
Dr. Frank Steiner and Dr. James Grinias present new features in the Vanquish system that allow for easy method transfer, and discuss how thermal column environments can revolutionize your UHPLC experience. Discover how you can push chromatographic boundaries to separate your science from the status quo.
