Vanquish Flex UHPLC Systems

Easier method development and routine analysis

For assays that require more flexibility to accommodate all applications, the Thermo Scientific Vanquish Flex UHPLC systems enable you to increase your productivity and drive innovation without compromising quality. Whether you need an LC or LC-MS solution, the flexibility of the Vanquish Flex systems with binary or quaternary solvent blending provides the most advanced performance through better separations, more results and easier interaction.

Contact us   Virtual demo

New benchmarks in accuracy, precision, and sensitivity

As a member of the Vanquish UHPLC product line, the Vanquish Flex Binary UHPLC system and Vanquish Flex Quaternary UHPLC system share all Vanquish-inherent values, such as a design focus on uptime, robustness and reliability. The Vanquish Flex systems provide:

  • Unsurpassed retention time and peak area precision
  • Highest detector sensitivity and lowest baseline noise
  • Less maintenance and easy set-up with Thermo Scientific Viper fingertight fittings
  • Dedicated solutions for exceptional LC-MS performance

Also benefit from the industry-leading, easy-to-use and compliant Thermo Scientific Chromeleon Chromatography Data System (CDS) with eWorkflow method setup, dedicated ePanels, Open Access, and smart tools. Chromeleon CDS delivers advanced system communication with single-point intelligent control and functionality, and provides direct plugins for the Vanquish Flex UHPLC systems to other manufacturers' chromatography data systems.

Choose from two Vanquish Flex UHPLC systems

Continuous, worry-free operation

Continuous, worry-free operation

Reliable and continuous worry-free operation of HPLC instruments is critical for analytical laboratories to achieve the highest productivity and dependable results.

The Thermo Scientific Vanquish Solvent Monitor delivers productivity improvements through the avoidance of unintended dry solvent channels and supports your laboratory's compliance efforts by automatically logging eluent changes. Additionally, monitoring of your waste container levels can ensure your laboratory's smooth operation by preventing hazardous spills. 

Solvent and waste levels can be monitored directly on the instrument, through the Thermo Scientific Vanquish User Interface, or remotely with Thermo Scientific Chromeleon Chromatography Data System (CDS) software.

Continuous awareness of system status

Continuous awareness of system status

Lab professionals spend a large amount of time interacting with laboratory instruments. The more quickly that operators can understand system status, the more easily they can keep the system delivering results. 

With the crisply-designed Thermo Scientific Vanquish User Interface, system health, performance, and equilibration status can be seen at a glance. Additionally, simple maintenance tutorials guide operators to keep the system dependably delivering results. All this can be done remotely or locally, and even when there is no CDS.

Overview of the Vanquish UHPLC systems

    Vanquish Flex
Binary UHPLC System
Vanquish Flex Quaternary UHPLC System
  Solvent blending High pressure binary solvent blending for fast and reliable UHPLC Low pressure quaternary solvent blending for flexible method development
Performance System pressure
Up to 1000 bar
Retention time precision
Flow range
0 – 8 mL/min
System Features Design Modular Modular
SmartInject technology for unsurpassed retention time precision    
SmartFlow technology for excellent flow precision    
Pump High-pressure gradient proportioning Low-pressure gradient proportioning
Active and passive pre-heating    
Multi-mode column thermostatting    
Sample cooling  
Temperature range: 4 – 40 °C
Temperature range: 4 – 40 °C
System components Pump Vanquish Binary Pump F
UHPLC performance for demanding routine application up to 1000 bar
Vanquish Quaternary Pump F
UHPLC performance with more solvent flexibility up to 1000 bar
Autosampler Vanquish Split Sampler FT
For applications up to 1000 bar
Extended sample capacity Vanquish Charger (optional)
An intelligent, robotic rack and plate feeder that automatically loads samples in the autosampler and extends the sample capacity of all Vanquish samplers to up to 8832 samples (23 wellplates or 12 vial racks) with innovative air-stream cooling and barcode reading for inventory management.
Column compartment Vanquish Column Compartment
Provides two column thermostatting modes (still and forced air), active and passive solvent pre-conditioning and post-column cooling for optimized control of your separations and advanced method transfer.
  Virtually zero dead volume system connections Viper UHPLC Fittings Kits
Order all the UHPLC fittings and capillaries you need for your system or application in a single kit
= Not applicable = Poor = Good = Better = Best

Compatible components for all Vanquish UHPLC systems

Detector options Vanquish columns Chromeleon CDS
Extend pressure capabilities and robustness by using columns that were developed for Vanquish systems, allowing you to separate your science better, faster, and easier than ever before.
All Vanquish systems can be used with any of our HPLC and UHPLC columns
  • Streamlines your data processing
  • Industry-leading ease of use and intelligent functionalities
  • Outstanding data integrity
  • Unique user guidance and hardware automation features designed for Vanquish systems

Discover the best HPLC systems for your applications and budget

Discover the best HPLC system for your applications and budget

Use these tools to help you decide

HPLC Systems Selection Guide
Use this tool to rank the top HPLC instruments for your applications based on your responses to simple pull-down menus.

HPLC System Total Cost of Ownership Calculator
Use this tool to estimate your cost for purchasing and running Thermo Scientific HPLC and UHPLC systems. You can compare costs between instruments.

LC Method Transfer Calculator
Use this online calculator to transfer methods from HPLC to UHPLC conditions. Calculate the new gradient table, adjust sample volumes and run times if applicable.

Interact with Vanquish

Interact with Vanquish

Take a virtual tour of the Vanquish and see how each module’s advanced technology will separate your science from the status quo.

 Take the tour

CMD SchemaApp code