HPLC and UHPLC for Biologics Development, Identification & QC

Now you just need one system

Drug development workflows in biopharmaceutical laboratories can be demanding, requiring extensive data, accurate results, and fast separations. The Dionex UltiMate 3000 Biocompatible Rapid Separation (BioRS) system perfectly matches the demands for biomolecule separations to run various modes of chromatography in UHPLC. This goes beyond reversed-phase UHPLC: it is genuine Bio UHPLC for proteins, peptides, and biotherapeutics.

BioRS system features

Selection of main features:

  • Pressure of up to 100MPa (15,000 psi)
  • Flow rates of up to 8mL/min
  • Short sampler cycle times (< 20 seconds)
  • Wide column thermostatting range (5°C to 110°C)
  • Ultrafast data collection and processing (up to 200Hz)
Unique column chemistries

The gold standard ProPac WCX and MAbPac columns can be used with salt or pH gradient LC. In addition new chemistries like the GlycanPac AXH-1 column are available to separate both labeled and unlabeled N- and O-glycans by charge, size, and isomer.

Seamless MS integration

The UltiMate 3000 BioRS system combines easily with our best-in-class mass spectrometers. Routine confirmation on iontrap or triple quad mass spectrometers, or discovery on high resolution Q Exactive, Exactive Plus or Orbitrap hybrids, all seamlessly integrate with the UHPLC+ solutions offered by the UltiMate 3000 BioRS system.