Drug Screening and Confirmation

Close your uncertainty gap

We can enable your laboratory with the right solutions to improve confidence in results and meet your everyday forensic toxicology lab demands. With an increasing number of drug intoxications reported annually, new legislation and more workplace testing, forensic scientists, law enforcement agencies, and drug testing laboratories require faster screen-to-confirmation methods to address case loads. Improving routine compound screening and confirmation turnaround time while staying ahead of tomorrow’s illicit drug compounds isn’t easy. We offer a variety of solutions to meet your budget and operational needs; while helping your laboratory analysts with first-time analysis success.

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Find the Trace with Orbitrap mass spectrometry

Simon Hudson, Technical Director at a division of LGC, discusses advantages of targeted and untargeted forensic drugs of abuse screening with high resolution accurate mass Orbitrap LC-MS/MS.

Increased designer drug introduction has put more pressure on the law enforcement agencies to quickly identify these compounds. Advancements in the mass spectrometry based assays have helped identify these compounds.

In this webinar Dr. Jean-Claude Alvarez, Professor of Medicine in Pharmacology at the University Versailles Saint Quentin-en-Yvelines explains how he and his team of experts analyze designer drugs in various matrices with MS techniques.

Tracking Designer Drugs
Tracking Designer Drugs

Combining solid phase extraction with high-resolution accurate mass LC-MS increases sample throughput and improves detection and identification of novel synthetic cannabinoids.

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Drug screening and confirmation workflow

Our solutions are designed to integrate into your existing operations whether you need to optimize throughput, sensitivity or build your lab of the future—from component to full workflow options. Where high sample throughput and turn-around time pressure exists, LC-MS is increasingly the preferred method of analysis over traditional techniques—offering the ability to eliminate “send-outs”. Toxicologists are able to obtain sensitivity and specificity, in less time.

Sample collection and labeling

Sample collection and storage conditions for routine drug testing and/or forensic case investigation are quite critical to maintain the integrity of these samples. Collection of oral samples requires specialized tools that are simple and easy to use yet allows enough sample collection for further downstream analysis. Forensic samples upon collection need to be stored in a well labeled container throughout the analysis process to maintain a continuous chain of custody. Thermo Scientific offers efficient tools to collect and store samples that are a requirement for many forensic labs.

Sample collection

Simplify the collection of oral samples for routine drug testing with our Thermo Scientific™ Oral-Eze™ Oral Fluid collection device. It provides all the advantages of previous collection systems with the added benefit of our indicator window technology—taking the guesswork out of sample collection.

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Track samples through various forensic workflows using the Thermo Scientific™ Virtuoso™ vial labeling system—a very defensible vial labeling tool. No smear, no smudge but clean professional vial labeling to maintain a continuous chain of custody.

Sample preparation

For laboratories using GC and GC-MS applications for screening and/or confirmation and identification, improve separation and detection with our selection of GC derivatization reagents. For applications requiring solid phase extraction (SPE), Thermo Scientific sample preparation products reduce time and repetitive functions you need to perform, while providing consistency and accuracy of results. We offer a broad range of manual and semi-automated SPE consumable solutions.

See SOLA in action

Get greater reproducibility and cleaner, more consistent extracts with the first-ever fritless cartridges and plates.


Rely on our drugs of abuse screening solutions as part of your drug screening and confirmation testing program. Thermo Scientific offers a variety of screening options to be used as stand-alone instruments or integrated into your laboratory automation workflow. Our systems are designed to offer you the best solution to support your unique laboratory challenges while improving operational efficiency and result integrity. Our portfolio of products is used in a variety of municipalities including drug courts, correctional institutions, city, county, state, country, and national laboratories. 

  • Rapidly screen urine
  • Easy to use for new analysts
  • Process 120 samples per hour
  • Fully automated
  • Methods traceable to international reference methods and materials
  • Rapidly screen urine
  • Easy to use for new analysts
  • Process 190 samples per hour
  • Fully automated
  • Methods traceable to international reference methods and materials
  • Screen, quantify, and confirm with the sensitivity & specificity for your everyday demands
  • Low to medium sample volume
  • Performance within budget
  • Ideal for applications with volatiles and non-polar compounds
  • Screen, quantify, and confirm enabled by superior sensitivity 
  • High sample throughput
  • Robust system offers fastest screen-to-confirm results
  • Little to no sample preparation

Related products
  • Reagents, calibrators, controls and collection devices
  • Chemistry analyzers
  • Sample derivitization solutions
  • GC and LC columns & consumables
  • GC-MS quadrupole solutions
  • LC-MS solutions
  • Further optimization performance with our specialty ion sources; including DART (Direct Analysis in Real Time)
  • For clinical laboratories, see our diagnostic instruments 
Simplified drugs of abuse testing
Automated drugs of abuse analysis
Automated random access benchtop solution for small and medium laboratory settings.
Application notes, posters and presentations
Screening reagent kits

Drug screening laboratories around the world test with confidence using our gold standard Thermo Scientific™ CEDIA™ and Thermo Scientific™ DRI™ technologies, widely accepted as the leading methods for testing urine samples. With our drugs of abuse testing solutions, you can obtain accurate and reliable results rapidly on a wide range of clinical chemistry analyzers. Streamline your laboratory’s productivity with our convenient, liquid, ready-to-use DRI assays. 

Our most popular drugs of abuse applications

DRI drugs of abuse assays

CEDIA drugs of abuse assays

Confirmation and identification

When accurate, reproducible, and rapid separations are critical, choose from our solutions to help you successfully analyze compounds limited in amount or availability amid complex matrices. Mass Spectrometry (MS) is increasingly used in forensic toxicology because it is versatile, fast, and accurate. Thermo Fisher Scientific offers a family of MS technologies to deliver the accuracy, sensitivity and throughput your lab requires and work within your budget and workflow needs. Our portfolio of products is used in a variety of municipalities including drug courts, medical examiner, city, county, state, country, and national laboratories.

TRACE™ 1310 Gas Chromatograph and TSQ™ 8000 Evo Triple Quadrupole
  • Quantify and confirm for your every day demands
  • Low to medium sample volume
  • Performance within budget
  • Ideal for volatiles and non-polar  compounds
UltiMate™ 3000 HPLC system and LTQ XL™ Linear Ion Trap Mass Spectrometer
  • Low level detection and more information from every sample
  • Low to medium sample  throughput
  • Performance within budget
  • Little to no sample preparation
UltiMate™ 3000 HPLC system and TSQ Endura™ Triple Quadrupole system
  • Screen and quantify multiple compound classes with superior sensitivity
  • Ultrafast SRM leading to the fastest quantitation workflow
  • No sample preparation and easy method development
  • Highly reliable results with different sample types and matrix
UltiMate™ 3000 HPLC system and Q Exactive™ Focus Hybrid Quadrupole-Orbitrap
  • High Resolution Accurate Mass (HRAM) enables quantitation and identification for a number of compounds
  • Easy method development; fast screen-to-confirm results
  • Minimum sample preparation
  • HRAM enables efficient target and unknown identification

Related Products
Additional resources
Application notes, posters and presentations
Publications & citations
Analysis software solutions for your screening workflows; including identification, quantification & confirmation

Rather than taking a one-size-fits-all approach, Thermo Scientific is committed to developing products to meet the needs of our research to routine Toxicology laboratory professionals. Our ToxFinder™ software has been tested and developed in conjunction with laboratories like yours.

ToxFinder™ software

  • Designed for toxicology experiment-specific routine screening and quantitation in a single workflow
  • Easy-to-use for novice mass spectrometry users
  • Easy data review requires minimum user involvement
  • WYSIWYG custom report tool makes tailored reports easy
  • Intended for use with Thermo Scientific™ mass spectrometry instruments

TraceFinder™ software

  • Perform targeted screening, routine quantitation, and qualitative review of GC, GC-MS, LC, and LC-MS data
  • Offers additional software features needed to aid in forensic research experiment design
  • Intended for use with Thermo Scientific™ mass spectrometry instruments
  • Supports non-mass spectrometer optical detectors

Additional resources
High-Resolution Accurate-Mass MS/MS Spectral Libraries
LIMS solution for forensics

Efficiently manage the increasing volume of lab data that is generated related to samples used in evidence with the Thermo Scientific™ LIMS Solution for Forensics, a key requirement of the forensics laboratory because it is flexible and secure and is designed for rigorous testing and real-time monitoring.

See the LIMS for Forensics solution

Additional resources