Stay one step ahead. The Tox Explorer Collection helps the world's toxicology community navigate with ease to solve complex analytical challenges and increase laboratory productivity. Built upon a single software solution, the Tox Explorer Collection comes equipped with a standardized LC-MS method with retention times, (U)HPLC column, experimentally obtained compound database and library, as well as on-site LC-MS/MS instrument set-up and Tox Explorer application training, enabling smooth start-up and implementation.
For increased confidence in data and productivity in your laboratory, the Tox Explorer Collection is now available with Thermo Scientific Orbitrap MS and Thermo Scientific TSQ Plus triple quadrupole mass spectrometer platform options.
Improve efficiency and productivity by capitalizing on an optimal combination of preparation guidelines, outstanding LC, robust MS, intuitive software, an extensive compound library and easy-to-implement methods—all backed by comprehensive training and application support. And, the flexibility to choose the mass spectrometer option that meets your needs.
Get excellent dynamic range and highly accurate mass measurements. HRAM option includes experimentally obtained compound database and HRAM spectral library with retention times of over 1800 compounds.
Increase productivity with SRM acquisition speeds enabling faster polarity switching of both positive and negative compounds. Triple quadrupole option includes experimentally obtained compound database and retention times of over 1100 compounds.
The high-pressure Vanquish system provides a standardized LC method for consistent retention time performance.
Ultra-high-resolution MS delivers high confidence results for a broad range of toxicology compounds.
Fast SRM acquisition speed maximizes productivity and quantitative performance for toxicology analyses.
Solid core 2.6µm particles deliver optimum resolution and separation for a broad range of toxicology compounds.
Thermo Scientific Orbitrap technology platforms offer high resolution mass spectrometry and better mass accuracy without loss of sensitivity and provide positive/negative polarity switching in one analytical run, saving time and offering greater confidence in data output. Screening, identification, confirmation and quantitation can all be performed on one mass spectrometry platform. One of the key benefits of using high resolution accurate mass (HRAM) mass detection for toxicology analyses is the ability to use retrospective data to help with the identification of novel designer drugs.
Extracted ion chromatogram of 100+ compounds covering a range of drug classes hydrophobicities, and polarities.
We have developed an in-house broad coverage ‘open’ screen for NPS, drugs of abuse and medications based on Q Exactive Orbitrap mass spectrometers that has allowed us to successfully deliver forensic toxicology services for the past 10 years."
The Tox Explorer Collection on the Orbitrap Exploris 120 MS has significantly enhanced the screening service. Additional analytes in the database have provided enhanced coverage helping in the identification of unique compounds in various coroner’s cases; the greater scan speed of the Orbitrap Exploris also allows complex acquisition workflows including polarity switching and targeted data dependent MS2 (ddMS2) in a single analysis.
Technical Director, LGC ASSURE
Watch a brief demonstration of how TraceFinder software can be used in conjunction with Thermo Scientifc mzVault library manager to acquire, monitor, process, review, and report data.
Whiteboard video highlighting the benefits of the Tox Explorer all-in-one toxicology solution and advantages of triple quadrupole mass spectrometry for drug screening and quantitation.
Tox Explorer Collection: Be Confident with a Concise and Comprehensive Toxicology solution
Tox Explorer Collection: LC-MS/MS with High-Resolution Accurate-Mass (HRAM) Mass Spectrometry
HRAM screening, quantitation, and confirmation of drugs with Tox Explorer Orbitrap Exploris platform
Screening and semi-quantitation of 212 fentanyl analog compounds by the Orbitrap Exploris 120 mass spectrometer
LC-MS technology enables rapid, accurate, easy-to-use methods to ensure success in toxicology analysis.
All-in-one LC-MS/MS toxicology solution for drugs of abuse quantitation using the TSQ Quantis Plus mass spectrometer