This proven, easy-to-implement method combines sample preparation guidelines and a variety of LC-MS options with an extensive mass spectral library for targeted screening, proven methods and intuitive software equipped with customizable reporting templates. It includes application support and training for confident, high quality results.
The compound database and library contain comprehensive information on more than 1,500 compounds of interest and the tested, proven analytical method ensures enhanced confidence in the data quality by eliminating false results, saving both time and cost.
Optimized for quick start-up and ease of use, the Tox Explorer collection is designed to improve efficiency and reduce cost for the analysis of drug compounds in multiple biological matrices with unprecedented speed, ease, and confidence, regardless of user experience level.
Beyond resolution: gaining confidence in targeted screening and quantitation in toxicology with Thermo Scientific Orbitrap Technology
Tox Explorer Collection allows every toxicology researcher to capitalize on a comprehensive and concise collection of instruments, library, methods, etc., to achieve the desired confidence in data.
Comprehensive LC-MS Workstream: Sample Collection to Reporting of Toxicology Analytes
Improve efficiency and productivity by capitalizing on an optimal combination of preparation guidelines, outstanding LC, robust MS, intuitive software, an extensive compound library and easy-to-implement methods—all backed by comprehensive training and application support.
Screen, identify, confirm, and quantitate in a single toxicology analysis using one mass spectrometer equipped with Orbitrap technology.
The Thermo Scientific Q Exactive Plus benchtop LC-MS/MS combines high performance quadrupole precursor selection with HRAM Orbitrap detection to deliver high performance and tremendous versatility.
Tox Explorer HRAM Solution
High resolution and mass accuracy
Thermo Scientific Orbitrap technology platforms offer high resolution mass spectrometry and better mass accuracy without loss of sensitivity and provide positive/negative polarity switching in one analytical run, saving time and offering greater confidence in data output. Screening, identification, confirmation and quantitation can all be performed on one mass spectrometry platform. One of the key benefits of using high resolution accurate mass (HRAM) mass detection for toxicology analyses is the ability to use retrospective data to help with the identification of novel designer drugs.
- Screen, identify, confirm, and quantitate – all with one instrument
- Analyze a broad spectrum of compounds in one run
- Perform retrospective analysis without requiring additional experiments
- Obtain comprehensive MS/MS spectra without the need to average, while accessing positive and negative compounds in one run
- Utilize data-dependent acquisition for the identification of unknown structures via MS/MS spectra
- Exceptional mass accuracy and stability within and between runs—even at low mass ranges— ensures confidence in results
HRAM XIC chromatograms of a select number of analytes ranging from ethyl glucaronide (EtG) to tetrahydrocannabinol (THC). Detection of hydromorphone in full scan mode with mass accuracy of -2.78 ppm, using external calibration. Identification of hydromorphone using MS/MS without averaging scans.
Tox Explorer Platform Components
|Part number||Description||Price (USD)|
|OPTON-31039||Tox Explorer: HRAM||Request a quote ›|
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"We have been using mass spectral libraries since 1987 to aid in the identification of mass spectra from full scan and MSn GC-MS, MSn LC-MS and more recently HRAM MS2 LC-MS and have constructed several in house mass spectral libraries. When I talk about mass spectral libraries to non-experts, I liken mass spectra to ‘fingerprints’ for chemicals and in combination with HRAM measurement, the fingerprints become far more specific. Ultimately, the more entries in a mass spectral library the better, and more recently with mzCloud, the information is present for anybody to use.”
Technical Director, Laboratory and Managed Services