Ion Chromatography Mass Spectrometry (IC-MS)

Increase the power of IC with MS detection

Utilize mass detection when you need to ensure analytical confidence and dramatically improve the detection capability of your Thermo Scientific Dionex Integrion or ICS-6000 HPIC system. Ion chromatography with mass spectrometry (IC-MS) maximizes the ability to detect and quantify unexpected co-elutions of components and to confirm trace components.

Popular IC-MS products
IC-MS systems

Coupling MS with your IC can give you more information from every sample:

  • Higher sensitivity
  • Accurate quantitation
  • Peak confirmation and evaluation of chromatographic peak purity
  • Increased efficiency
Triple Quadrupole IC-MS

Need sensitive, fast, and robust quantitation of a variety of molecule types? For complex samples, the high sensitivity and selectivity of MS/MS using selected reaction monitoring (SRM) provides the most precise and accurate quantitation using IC-MS.

Orbitrap IC-MS

Thermo Scientific Orbitrap mass spectrometers generate high-resolution and accurate-mass data, thereby enhancing sensitivity in trace analyte detection, characterization, and quantitation. That's why they are used in research applications—in particular, life science applications such as metabolomics.

Triple Quadrupole IC-MS

Need sensitive, fast, and robust quantitation of a variety of molecule types? For complex samples, the high sensitivity and selectivity of MS/MS using selected reaction monitoring (SRM) provides the most precise and accurate quantitation using IC-MS.

Orbitrap IC-MS

Thermo Scientific Orbitrap mass spectrometers generate high-resolution and accurate-mass data, thereby enhancing sensitivity in trace analyte detection, characterization, and quantitation. That's why they are used in research applications—in particular, life science applications such as metabolomics.

Which mass spectrometer do I choose?

Mass Spectrometer Analyzer Mode of Operation MS MS/MS Sensitivity Peak Confirmation Structural Elucidation
ISQ EC MS Quadrupole Single ion monitoring (SIM)
TSQ Altis MS Triple Quadrupole Selected reaction monitoring (SRM)
TSQ Quantis MS Triple Quadrupole Selected reaction monitoring (SRM)
Q Exactive MS Orbitrap mass analyzer High Resolution Accurate Mass (HRAM)
Orbitrap Fusion MS Orbitrap mass analyzer High Resolution Accurate Mass (HRAM)
  = Not applicable   = Poor   = Good   = Better   = Best

IC-MS basics and benefits videos


Polar ionic pesticides may occur as residues in food and water, but may not be included in pesticide monitoring programs because they are difficult to analyze using generic multi-residue methods. Recent advances using the Quick Polar Pesticides (QuPPe) method combined with IC-MS/MS have successfully demonstrated the applicability of this method for the analysis of anionic and cationic polar pesticides.

Register to watch ›


Resources