Liquid Chromatography Mass Spectrometry (LC-MS)

Profile, screen, identify and quantify a wide variety of compounds with confidence

Our next generation Thermo Scientific LC-MS systems deliver on ease without sacrificing high performance. A unified instrument architecture enables same performance accessories between systems, facilitates easier method transfer, and accelerates familiarization for new users. Intelligence-driven systems enables the highest quality mass spectrometry data for increased confidence. Pre-defined experimental conditions enables more users to access and succeed. Streamlined data processing software, algorithms and libraries address the most challenging research and routine applications.

Browse our complete portfolio below, or let one of our experts help you tailor a selection specific to your application and workflow needs.

Contact us

Popular LC-MS products
Q Exactive HF-X Hybrid Quadrupole-Orbitrap Mass Spectrometer
LC-MS webinar series

LC-MS webinar series

Expand your application knowledge

Our LC-MS on-demand webinar series expands your application knowledge for pharma, biopharma, environmental, omics, food, forensics and clinical research and more. Learn how the latest high-performance mass spectrometry solutions can enable your laboratory to solve your most pressing analytical challenges, regardless of sample type. 


Featured LC-MS categories

Orbitrap mass spectrometers generate high-resolution and accurate-mass data, thereby enhancing sensitivity in trace analyte detection, characterization and quantitation, and comprehensive sample analysis.

Empowering translational research scientists to more extensively deploy MS for rigorous, high-throughput protein identification, quantitation and structural characterization the Orbitrap Exploris 480 MS combines proven technology, advanced capabilities and an intelligence-driven analytical framework.

Push the limits of detection, characterization and quantitation with Thermo Scientific Orbitrap Tribrid mass spectrometers that enable multiple sophisticated modes of analysis.

Move from compound discovery into targeted quantitation for your sample type by choosing from a broad portfolio of Thermo Scientific Q Exactive Quadrupole-Orbitrap mass spectrometers.

For general purpose mass spectrometers, Ion trap mass spectrometers are cost-effective and can easily be operated by students learning the fundamentals of MS or for analytical applications.

From achieving ultimate sensitivity requirements, robustness, reliability, and speed, triple quadrupole LC-MS systems help you address your challenges in routine, targeted quantitation for all molecule types.

These economical high-performance MS systems have the capacity to keep up with even the fastest UHPLC applications.

From ensuring high productivity demands to offering increased confidence, high performance Class I medical devices for in vitro diagnostic use addresses the critical requirements in laboratory developed test results.

Online sample preparation and multichannel HPLC combine to lower per-sample costs while increasing sample throughout and data quality.

The right complement for our outstanding LC-MS systems, our software offers most comprehensive solution to data acquisition, processing, analysis, and reporting.

Optimize MS workflows and performance with a line of specialized ion sources, alternative dissociation techniques, probes that optimize MS workflows and performance to help you obtain the most sensitive data possible.

Choose from a variety of high quality Thermo Scientific chromatography consumables to meet your separation needs.

Comprehensive, reliable LC-MS platform solutions that enable clinical laboratories to achieve desired productivity and throughput goals, while ensuring confidence in results in laboratory developed tests (LDTs).


New! Introducing LC-MS Medical Devices for In Vitro Diagnostic Use

New! Introducing LC-MS Medical Devices for In Vitro Diagnostic Use

The new portfolio of Thermo Scientific LC-MS Medical Devices for laboratory developed tests offers the clinical laboratory six unique choices that meet a wide range of throughput and sensitivity needs.


New! VeriSpray PaperSpray ion source is a faster path to MS analysis
New! VeriSpray PaperSpray ion source is a faster path to MS analysis

Get the ideal alternative to the complexity of chromatography-based solutions with the Thermo Scientific VeriSpray PaperSpray ion source, the no-LC alternative for MS analysis.

Learn more


Mass Spectrometry Support Center

Mass Spectrometry Support Center

One resource for all your support needs related to mass spectrometry instruments and software. Obtain relevant technical information, view tips and tricks when starting an experiment, and/or find answers to some common problems.


Featured applications

Our optimized kits, reagents and devices enable quick and easy sample preparation, protein quantitation, and instrument calibration.

Our advanced instrumentation and analytical workflows can help simplify the challenge of biopharmaceutical analysis.

Our high-performing instruments and software provide a high-level confidence in MS-based biomarker discovery and method development for biomarker verification.

Whether you need to screen and confirm known compounds, identify unknowns or advance forensic research, we offer a solution to meet your current and future needs.

Our high-resolution accurate-mass (HRAM) Orbitrap mass spectrometers, enable broader and deeper analysis into the proteome than ever before.

Harness the power of metabolomics to gain in-depth biological insight, facilitate biomarker discovery, and advance scientific research.

Our integrative structural biology solutions use complementary mass spectrometry (MS) and cryo-EM techniques that characterize complex and dynamic structure-function relationships.

Our innovative techniques and instrumentation can help you keep pace with the identification and quantitation of emerging contaminants.

Affordability made easy
Affordability made easy

Interested in financing options, purchasing a factory-certified refurbished LC-MS instrument or trading-in your existing mass spectrometer for something better? Choose from a wide selection of high performance systems from the most routine, for all levels of experience, to the most sophisticated and advanced research. We can get you to greater productivity at an affordable price.

Learn more