ZipChip Interface for Mass Spectrometry

ZipChip System: a seamless workflow for CE/ESI-MS analysis of biological samples

Integrate capillary electrophoresis (CE) and electrospray ionization (ESI) into a single microfluidic device to rapidly prepare, separate, and electrospray biological samples directly into your Thermo Scientific mass spectrometer. The portable size ZipChip Interface directly mounts onto select models of Thermo Scientific mass spectrometers, and creates a seamless CE/ESI-MS workflow that offers fast CE separation, nano-spray level sensitivity, and HRAM spectrometry for the characterization of intact proteins, antibody drug conjugates (ADCs), antibody subunits, peptides, and metabolites.

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The ZipChip Interface is a Class 1 laser product in compliance with 21 CFR 1040.10 and 1040.11 except for deviations pursuant to laser notice No. 50.

Featured ZipChip products

Major ZipChip applications


  • Intact protein/antibody analysis
  • Antibody subunits analysis
  • Peptide mapping
  • Metabolites and small molecules analysis


  • Antibodies
  • Antibody drug conjugates (ADCs)
  • Intact proteins
  • Peptides
  • Amino acids
  • Small molecules


  • Cell lysates
  • Growth media
  • Plasma
  • Blood
  • Urine
  • Biopharma end products
  • And more…

How the ZipChip Interface works

Schematic of ZipChip HR microfluidic chip
Schematic of ZipChip HR microfluidic chip
Top open view of ZipChip microfluidic chip well structures
Top open view of ZipChip microfluidic chip well structures

Sample preparation

  • Minimal or no sample preparation is required for typical biological samples.
  • Desalting occurs on the chip to clean up high salt concentrations, residual detergents, and other production chemicals.

Capillary electrophoresis separation and electrospray ionization

  • Analytes separate due to differences in electrophoretic mobility, which is simply a function of the charge and size of the analyte.
  • Analytes are electrosprayed directly into the mass spectrometer through the ESI emitter on the corner of the microfluidic chip.
  • Stable, sensitive nano-spray ensures the best combination of sensitivity and robustness.

Analysis time

  • Entire CE/ESI-MS analysis can be complete in only 2-3 minutes for most biological samples which can significantly improve lab productivity.

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