Orbitrap Exploris Mass Spectrometers

Fast track to confident results

Thermo Scientific Orbitrap Exploris mass spectrometry is quantitative high-resolution, accurate-mass (HRAM) liquid chromatography mass spectrometry (LC-MS) with record-setting performance for your next-generation laboratory. The power of built-in intelligence, sensitivity and selectivity delivers depth of analysis to the lowest levels with high quantitative accuracy and precision. This extraordinary power is now available in an expanded portfolio to meet your exact analytical requirements. Scale up your research and translate your results more rapidly and simply than ever before with Orbitrap Exploris mass spectrometry.


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The evolution of 20 years of Orbitrap technology

Productivity redefined

Orbitrap Exploris 120 mass spectrometer

Consistent and accurate data, operational simplicity, instrument ruggedness for method development and everyday testing.

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Leading Performance

Orbitrap Exploris 240 mass spectrometer

Precision and accuracy to drive discovery, scale up and achieve impact, with application versatility and operational simplicity.


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Extraordinary Simplified

Orbitrap Exploris 480 mass spectrometer

Next-level insights, exploratory and targeted quantitation, next-gen power, performance, and ease of use for proteomics and biopharma applications.

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Why choose an Orbitrap Exploris mass spectrometer for your lab?

Market leading resolution for uncompromising data certainty

The combination of high-resolution, mass accuracy and stability ensures you have the highest level of spectral quality to help simplify your most complex analytical challenges.

Day-to-day performance consistency

Set it and forget it for days of maximum mass accuracy with built-in internal system calibration.

Out-of-the-box simplicity

Intuitive tuning, single-click calibration, drag-and-drop method setup, and pre-defined experiments driven by next-generation software are designed to help you get to reportable results easier, every day, for all users.

Improve lab operations with a compact footprint

Overcome space challenges even though your lab may be experiencing growth in sample volume, while still delivering maximum business value with the MS performance you need and expect, without compromising quality of results.


Maximize your return on investment in a unified Thermo Scientific mass spectrometry architecture from data acquisition and analysis solutions


Which Orbitrap Exploris MS is best suited for your lab?

The Orbitrap Exploris mass spectrometry systems offer a variety of performance features designed to address everyday research to routine testing demands and ideal for addressing mass spectral analysis of low-level components in complex matrices applications. Find the best system to design your next-generation laboratory capabilities and meet your changing business needs for more efficient screening (including targeted, suspected and nontargeted), identification, confirmation and quantitation.

  Orbitrap Exploris 120 Orbitrap Exploris 240 Orbitrap Exploris 480
  Thermo Scientific
Orbitrap Exploris 120
mass spectrometer
Thermo Scientific
Orbitrap Exploris 240
mass spectrometer
Thermo Scientific
Orbitrap Exploris 480
mass spectrometer
Analyses Targeted/non-targeted screening (MS)
Unknown Identification (MS)
Confirmation (MS/MS)
Absolute and Relative Quantitation (MS and/or MS2)
Ideal applications
Advanced Data-Dependent Experiments N/A Precursor Fit SureQuant, Precursor Fit, Boxcar Scanning
Next generation ion source interface Yes
Quick start methods for various applications Yes
Drag-n-drop method setup user interface Yes
Almanac Web-Based Monitoring and Management Requires Foundation 3.1 SP1 or later
Automated background exclusion N/A Requires Foundation 3.1 SP1 or later
Standard Features
Max Resolution (FWHM) @ m/z 200 120,000 240,000 480,000
Mass Accuracy (Internal Calibration) <1 ppm for up to 5 days with EASY-IC ion source
Calibration procedures Thermo Scientific Pierce FlexMix Calibration solution
Dynamic Range Up to 5 orders
Mass Range m/z 40 – 3,000 m/z 40 - 6000
(up to 8000 with BioPharma option)
Scan Speed Up to 22 Hz Up to 40 Hz
Polarity Switching 1.4 Hz
Ion Source interface OptaMax NG ion source
Multiplexing Up to 20 precursors/scan
Scan Functions Full MS, Full MS/AIF, SIM, DIA, t-MS2, t-SIM/dd-MS2 Full MS, Full Ms/AIF, SIM, t-MS2, DIA, dd-MS2, Full MS/AIF NL/dd-MS2, Full MS/dd-MS2
Dissociation In-source CID, HCD
Options and/or Upgrades
Intact Protein Mode N/A Yes
High Mass Range (HMR, up to 8000 m/z) N/A Yes
Sensitivity MS/MS: 200 fg reserpine on column S/N 100:1
SIM: 200 fg reserpine on column S/N 250:1
MS/MS: 50 fg reserpine on column S/N 100:1
SIM: 50 fg reserpine on column S/N 150:1
Chromatography system recommendations Vanquish Core HPLC system
Vanquish Flex HPLC system
Vanquish Duo HPLC system
Transcend Multichannel system
Vanquish Flex HPLC system
Vanquish Duo HPLC system
Vanquish Horizon HPLC system
EASY-nLC 1200 system
UltiMate 3000 RSLCnano system
Sources APCI/APPI Combination Ion Source FAIMS Pro Interface
APCI/APPI Combination Ion Source
EASY-Spray Sources
Nanospray Flex Ion Sources

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What’s inside the Orbitrap Exploris mass spectrometer

The highly optimized design of Orbitrap Exploris mass spectrometers permits a compact physical footprint while providing high performance components and many new functionalities that advance performance for critical applications. The design allows us to achieve a more compact footprint with a single turbo-pump with six-stage pumping, thus fewer moving parts, less electricity consumption, noise and weight.

Ion path and key components of Orbitrap Exploris 120 and Orbitrap Exploris 240 mass spectrometers

Ion path and key components of an Orbitrap Exploris Mass Spectrometer

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Orbitrap Exploris mass spectrometer ordering information

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Video: Compounding Insights—How to extract high confidence understanding from comprehensive Orbitrap Exploris HRAM data

Laboratories performing LC-MS applications strive for certainty when identifying detected compounds. For many small-molecule applications, conventional approaches aren’t enough. Laboratories require more, such as rich, high quality spectral information and fit for purpose data analysis software to make satisfactory identifications and characterization.

Thermo Scientific Compound Discoverer software helps you extract high-confidence understanding from comprehensive Orbitrap high-resolution, accurate-mass data.

Smart Note: How does AcquireX intelligent data acquisition improve laboratory efficiency

White paper: Challenges and emerging directions in single-cell proteomics

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