Push the limits of complex large and small molecule analysis
Thermo Scientific Orbitrap Tribrid mass spectrometers combine versatility, selectivity, sensitivity and speed to extend the limits of detection, characterization, and quantitation. They're equipped with a linear ion tap, a Thermo Scientific Orbitrap mass analyzer, and quadrupole mass analyzers to uniquely enable multiple sophisticated modes of analysis and experimental flexibility, every day.
Which Orbitrap Tribrid mass spectrometer is best suited for your lab?
Thermo Scientific Tribrid Orbitrap mass spectrometers enable high throughput screening and characterization of challenging samples including low-abundance peptides in complex matrices, determination of positional and posttranslational isoforms of intact proteins, resolution of isobaric metabolites, and protein structure characterization using chemical crosslinking. The tribrid mass spectrometers excel at a broad range of experimental applications from discovery to profiling and quantification, expediting scientific advancements on a single instrument.
Our Orbitrap Tribrid systems vary in terms of mass resolution and analysis modes. To find the system best suited to your laboratory’s specific needs, refer to the chart below to see how our Orbitrap Tribrid mass spectrometers compare.
The Orbitrap Tribrid mass spectrometers offer the following features:
|Orbitrap Fusion Lumos
|Resolution (FWHM) @ m/z 200||7,500-500,000||15,000-500,000||7,500-500,000|
|Optional 1M Resolution||No||Yes|
|Mass accuracy (internal calibration)||<3 ppm (<1 ppm)|
|Mass range||m/z 50-2,000||m/z 50-6,000|
|Ion source/transfer tube||OptaMax NG||—|
|Scan rates (under defined conditions)||30 Hz (OT) 40 Hz (IT)|
|Polarity Switching||One full cycle in 1.1 sec (positive and negative full scan with resolution of 30,000)|
|Minimum quadrupole mass filter||0.4 amu|
|Linear ion trap isolation||0.2 to 600 amu|
|MSn level||Up to 10|
|Synchronous precursor selection||No||Yes|
|Acquisition tool||Yes; requires Thermo Scientific Orbitrap Tribrid Series X.X SP1QF1|
|Primary application||Small molecule characterization and elucidation research for applications such as Metabolomics, Drug development Met ID, Extactables and Leachables, Industrial Environmental Health and more||Multi-omics, TMT, intact/top-down proteomics||Multi-omics, intact/top-down proteomics|
Related applications and technology
The Orbitrap ID-X Tribrid mass spectrometer in combination with Compound Discoverer software, AcquireX and mzLogic offers a compelling solution for the pharmaceutical industry. Learn how to address your metabolite ID challenges.
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