Go beyond with Orbitrap Tribrid MS for large and small molecule analysis

Go beyond with Orbitrap Tribrid MS for large and small molecule analysis

Built on revolutionary Thermo Scientific Tribrid architecture that combines the best of quadrupole, Orbitrap, and linear ion trap mass analyzers, Orbitrap Tribrid mass spectrometers enable high throughput analyses of challenging samples.

These include accurate and precise quantitation of low-abundance peptides in complex matrices, characterization of structural isomers, from drug metabolites to intact proteins, resolution of isobaric species, and native protein complexes structure characterization.

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Look inside an Orbitrap Tribrid Mass Spectrometer

The architecture inside of an Orbitrap Tribrid mass spectrometer enables a broad range of experimental applications from discovery to profiling and quantification, expediting scientific advancements while offering experimental flexibility, all on a single instrument.

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Explore our Orbitrap Tribrid instruments


Orbitrap Eclipse Tribrid MS

Thermo Scientific Orbitrap Eclipse Tribrid Mass Spectrometer is our flagship Orbitrap Tribrid instrument, designed for the highest performance across a wide range of applications. It was developed to produce the best results in quantitative proteomics, protein characterization and small molecule analysis. It features the latest, most innovative hardware, intelligent instrument control with the possibility of real-time database search, and an impressive set of optional functionalities, including the most recent high mass range MSn (HMRn) for native protein complex characterization and proton transfer charge reduction (PTCR) for complex spectra simplification through charge manipulation.

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One of the most impressive recent advancements in cell biology research is a single cell analysis. Comprehensive characterization of single-cell proteomes has a promise to provide a wealth of novel information about cellular development in the context of disease progression and response to treatment as a function of cell type. Recently Professor Ryan Kelly, at Brigham Young University, in collaboration with our company, developed an integrated workflow for single cell analysis, allowing for high throughput accurate quantitation of thousands of proteins in a single cell.

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“A revolution in single-cell proteomics is just beginning. The combination of nanoPOTS with the Orbitrap Eclipse Tribrid mass spectrometer, TMT reagents, and SPS MS3 with Real-Time Search provide the depth of coverage, quantitative accuracy, and throughput needed to propel this nascent field forward.”

Professor Ryan Kelly, Brigham Young University, UT

Dr. Erwin Schoof
Multiplexing Single Cell Proteomics: A Marriage of Sensitivity and Throughput

Dr. Erwin Schoof, Head of Proteomics Facility,
Technical University of Denmark Postdoctorial Fellow, Copenhagen University

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Dr. Ryan Kelly
One Cell at a Time: Single Cell Proteomics Becomes a Reality

Dr. Ryan Kelly, Associate professor
Chemistry and Biochemistry, Brigham Young University

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Dr. Erwin Schoof
Multiplexing Single Cell Proteomics: A Marriage of Sensitivity and Throughput

Dr. Erwin Schoof, Head of Proteomics Facility,
Technical University of Denmark Postdoctorial Fellow, Copenhagen University

Watch webinar

Dr. Ryan Kelly
One Cell at a Time: Single Cell Proteomics Becomes a Reality

Dr. Ryan Kelly, Associate professor
Chemistry and Biochemistry, Brigham Young University

Watch webinar


Orbitrap ID-X Tribrid MS


Orbitrap Fusion Lumos Tribrid MS


Orbitrap Fusion Tribrid MS


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Boost selectivity and enhance your proteomics workflow with FAIMS Pro Interface

High-Field Asymmetric waveform Ion Mobility Spectrometry (FAIMS) can be used to optimize ion selectivity and reduce chemical backgrounds during mass spectrometry assays. FAIMS successfully prevents interferences from co-eluting compounds and increases signal to noise ratios by 100-fold or higher.

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