Achieve the highest confidence in targeted compound detection and quantitation through leading sensitivity 

Greater than 6 orders of linear dynamic range with high selectivity. Enhanced acquisition speeds empower large-scale studies for translational workflow development or method optimization with effective dwell time settings as low as 0.3 milliseconds — 5 millisecond polarity switching maximizes productivity in fewer experiments.

Where data confidence is required, the instrumental features on the TSQ Altis Plus triple quadrupole mass spectrometer drive high-performance targeted experiments for complex matrices.

High-throughput screening and quantitation

Innovations in the ion source, mass analyzer, active Q2 collision cell, and RF electronics offer high sensitivity, selectivity, and superior acquisition speeds/polarity switching times that are ideal with ultra-high performance liquid chromatography (UHPLC) separations. With scheduled SRM acquisition and 600 SRMs/second, 1000’s of compounds can be screened or quantified per method. Fast data acquisition reaches the number of required data points for outstanding confidence at extremely low concentrations, in the most challenging matrices.

Expanded experimental capabilities

Integrated workflow solutions centered on the TSQ Altis Plus mass spectrometer address regulated requirements targeting a growing list of diverse compounds. New UHPLC and ion chromatography (IC) systems maximize sample delivery and separation capabilities, maintaining the sensitivity to meet minimum residue limits without costly sample preparation or derivatization steps. Thermo Scientific Chromeleon Chromatographic Data System (CDS) software controls all experimental attributes in a regulated environment to further drive productivity.

Operational simplicity

Targeted research and routine applications demand fast and responsive instrument control software, with intuitive operations. Simplified calibration approach consolidates steps needed by the operator, combining an intelligent instrument check and calibration routine. Direct method transfer from the previous generation Thermo Scientific TSQ mass spectrometers can be performed for equal or better performance without optimization.

Experimental determination of dwell times assigned to each transition has been automated based on user-defined chromatographic peak width and the option of fixed cycle time or optimal number of data points per chromatographic peak. Prioritization settings allow further adjustments.

Database integration

Method development for targeted acquisition methods requires a prior knowledge of optimal product ions and energetics. Utilization of experimental libraries created from discovery experiments can by-pass the need for purified standards and lengthy optimization routines. The output from processed data in Thermo Scientific TraceFinder software can be directly imported into the instrument method editor, streamlining large-scale study creation.

Discovery experiments, however, may not contain all compounds targeted in a study. Integration with Thermo Scientific mzCloud databases enables selection of additional compounds from the most advanced mass spectral database to be added into existing experimental methods.

Meet the TSQ Plus triple quadrupole mass spectrometers

Learn about the new hardware features driving next-level performance for targeted quantitation.

Watch now

40th Anniversary of Thermo Scientific Triple Quadrupole Mass Spectrometers

See how Thermo Scientific has been enabling labs to meet their quantitation challenges for over 40 years.

Watch now

Overcoming the challenges of anti-sports doping

Watch Dr. Ludovic Bailly-Chouriberry, Laboratory Director, discuss how the TSQ Altis Plus mass spectrometer increases productivity for anti-sports doping.

Watch now

Improving biotherapeutic PK studies

JUN QU, PhD. of SUNY Buffalo discusses improving the limit of quantitation for protein therapeutics using the TSQ Altis Plus mass spectrometer and FAIMS Pro Duo interface.

Watch now

Ideal solution for routine peptide quantitation

University of Washington Professor Michael MacCoss highlights the TSQ Altis Plus mass spectrometer delivering targeted protein methods and workflow solutions.

Watch now

Routine omics-scale lipid profiling

Learn how Dr. Julijana Ivanisevic of the University of Lausanne uses large-scale lipid analysis for populational screening.

Watch now

Meet the TSQ Plus triple quadrupole mass spectrometers

Learn about the new hardware features driving next-level performance for targeted quantitation.

Watch now

40th Anniversary of Thermo Scientific Triple Quadrupole Mass Spectrometers

See how Thermo Scientific has been enabling labs to meet their quantitation challenges for over 40 years.

Watch now

Overcoming the challenges of anti-sports doping

Watch Dr. Ludovic Bailly-Chouriberry, Laboratory Director, discuss how the TSQ Altis Plus mass spectrometer increases productivity for anti-sports doping.

Watch now

Improving biotherapeutic PK studies

JUN QU, PhD. of SUNY Buffalo discusses improving the limit of quantitation for protein therapeutics using the TSQ Altis Plus mass spectrometer and FAIMS Pro Duo interface.

Watch now

Ideal solution for routine peptide quantitation

University of Washington Professor Michael MacCoss highlights the TSQ Altis Plus mass spectrometer delivering targeted protein methods and workflow solutions.

Watch now

Routine omics-scale lipid profiling

Learn how Dr. Julijana Ivanisevic of the University of Lausanne uses large-scale lipid analysis for populational screening.

Watch now

To perform quantitation assays with confidence, you need a liquid chromatography mass spectrometry (LC-MS) workflow solution that is relevant to your goals

White Paper: Sensitivity and acquisition speed with triple quadrupole technology

Today’s analytical methods performing routine quantitation continue to evolve to meet new environmental and health risks. Experimental methods are modified to include more compounds measured at lower detection levels with faster gradients to address throughput. Therefore, specific LC-MS/MS performance characteristics are critical to evaluate productivity.

 Download white paper ›

White Paper: Triple quadrupole mass spectrometer portfolio

Learn about the hardware and software innovations implemented in the TSQ triple quadrupole mass spectrometer platform to address the current and future challenges in targeted quantitation.  The platform enhancements enable ultimate confidence in data quality with robust, reproducible, and reliable quantitative methodologies.

 Download white paper ›

Solutions for PFAS Testing

Workflows and instruments for reliable PFAS analysis

As knowledge about per- and polyfluoroalkyl substances (PFAS) grows, detecting these chemicals in environmental samples has become critical. PFAS contamination, often in the form of PFOA or PFOS, can be determined by one of several US EPA PFAS methods including Methods 533 and 537 for the determination of PFAS in drinking water and OTM-45 to test for PFAS in air emissions.

Learn more ›

As we identify chemicals that pose environmental and health risks, it is critical to find effective and responsive solutions for routine quantitation to address current and emerging regulations. Your quantitative solutions must address a wide range of analytical requirements to screen and quantitate low-level chemical contaminants. These compounds and methods are diverse, requiring integrated solutions to respond quickly and confidently while meeting regulations.

It is crucial to ensure safety and compliance for the world’s food supply, which is processed in different environments and under different regulations. Differences in pesticide development and implementation, as well as transportation and handling, make it complicated but important to develop workflow solutions to address current testing requirements as well as emerging threats and regulations. The TSQ Altis Plus mass spectrometer provides next-level performance to address these challenges.

Providing innovative solutions to help meet the demanding needs of clinical, forensic, and translational research, Thermo Fisher Scientific workflow solutions combine effective front-end solutions to the TSQ Altis Plus mass spectrometer to deliver confident data.

The bio/pharmaceutical drug development pipeline presents different challenges to researchers at every stage, from discovery through bioanalytical quantitation. Thermo Scientific TSQ Plus mass spectrometers leverage innovative hardware and software advancements to deliver productive solutions to enable our partners to deliver next-generation drugs to market faster with greater confidence.

Connect your laboratory to drive more insights from your data

Thermo Fisher Connect Platform is part of our full suite of digital capabilities for secure, cloud-based data storage, scientific analysis apps, and peer collaboration tools. In addition, our asset management tools allow you to remotely schedule time on your lab’s instruments and monitor your run via your mobile device.

Using Thermo Fisher Connect, it’s easy to connect, save, and synchronize your files to your secure, personal account, which includes 1 TB of free storage. Peer and document collaboration tools enable secure group collaboration.

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