Highlights
Achieve the highest confidence in targeted compound detection and quantitation through leading sensitivity
Greater than 6 orders of linear dynamic range with high selectivity. Enhanced acquisition speeds empower large-scale studies for translational workflow development or method optimization with effective dwell time settings as low as 0.3 milliseconds — 5 millisecond polarity switching maximizes productivity in fewer experiments.
Where data confidence is required, the instrumental features on the TSQ AltisPlus triple quadrupole mass spectrometer drive high-performance targeted experiments for complex matrices.
High-throughput screening and quantitation
Innovations in the ion source, mass analyzer, active Q2 collision cell, and RF electronics offer high sensitivity, selectivity, and superior acquisition speeds/polarity switching times that are ideal with ultra-high performance liquid chromatography (UHPLC) separations. With scheduled SRM acquisition and 600 SRMs/second, 1000’s of compounds can be screened or quantified per method. Fast data acquisition reaches the number of required data points for outstanding confidence at extremely low concentrations, in the most challenging matrices.
Expanded experimental capabilities
Integrated workflow solutions centered on the TSQ Altis Plus mass spectrometer address regulated requirements targeting a growing list of diverse compounds. New UHPLC and ion chromatography (IC) systems maximize sample delivery and separation capabilities, maintaining the sensitivity to meet minimum residue limits without costly sample preparation or derivatization steps. Thermo Scientific Chromeleon Chromatographic Data System (CDS) software controls all experimental attributes in a regulated environment to further drive productivity.
Operational simplicity
Targeted research and routine applications demand fast and responsive instrument control software, with intuitive operations. Simplified calibration approach consolidates steps needed by the operator, combining an intelligent instrument check and calibration routine. Direct method transfer from the previous generation Thermo Scientific TSQ mass spectrometers can be performed for equal or better performance without optimization.
Experimental determination of dwell times assigned to each transition has been automated based on user-defined chromatographic peak width and the option of fixed cycle time or optimal number of data points per chromatographic peak. Prioritization settings allow further adjustments.
Database integration
Method development for targeted acquisition methods requires a prior knowledge of optimal product ions and energetics. Utilization of experimental libraries created from discovery experiments can by-pass the need for purified standards and lengthy optimization routines. The output from processed data in Thermo Scientific TraceFinder software can be directly imported into the instrument method editor, streamlining large-scale study creation.
Discovery experiments, however, may not contain all compounds targeted in a study. Integration with Thermo Scientific mzCloud databases enables selection of additional compounds from the most advanced mass spectral database to be added into existing experimental methods.
Resources
As we identify chemicals that pose environmental and health risks, it is critical to find effective and responsive solutions for routine quantitation to address current and emerging regulations. Your quantitative solutions must address a wide range of analytical requirements to screen and quantitate low-level chemical contaminants. These compounds and methods are diverse, requiring integrated solutions to respond quickly and confidently while meeting regulations.
Direct analysis of selected per- and polyfluorinated alkyl substances (PFAS) in ground, surface, and waste water by LC-MS/MS
It is crucial to ensure safety and compliance for the world’s food supply, which is processed in different environments and under different regulations. Differences in pesticide development and implementation, as well as transportation and handling, make it complicated but important to develop workflow solutions to address current testing requirements as well as emerging threats and regulations. The TSQ Altis Plus mass spectrometer provides next-level performance to address these challenges.
Triple quadrupole technology for Halvec Lab’s novel routine gelatin analysis and targeted markers for identification of porcine trace elements
Food & environmental safety applications: Address challenges and achieve confident data
Providing innovative solutions to help meet the demanding needs of clinical, forensic, and translational research, Thermo Scientific workflow solutions combine effective front-end solutions to the TSQ Altis Plus mass spectrometer to deliver confident data.
Address challenges in drug monitoring for immunosuppressants, investigating potential biomarkers for disease targets, and measuring the output of endocrine glands.
Quantitative analysis of antifungal drugs using PaperSpray tandem mass spectrometry for clinical research
Improving targeted peptide quantification: combining a TSQ Altis with a FAIMS Pro interface for peptides in complex matrices
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Remote monitoring
Connect your laboratory to drive more insights from your data
Thermo Fisher Connect Platform is part of our full suite of digital capabilities for secure, cloud-based data storage, scientific analysis apps, and peer collaboration tools. In addition, our asset management tools allow you to remotely schedule time on your lab’s instruments and monitor your run via your mobile device.
Using Thermo Fisher Connect, it’s easy to connect, save, and synchronize your files to your secure, personal account, which includes 1 TB of free storage. Peer and document collaboration tools enable secure group collaboration.
Learn more about how cloud-based technologies are becoming more prevalent in laboratories
Learn more about Thermo Fisher Connect Platform
