Metabolomics applications using mass spectrometry
The close link to the phenotype and non-invasive nature of metabolomics makes it an ideal tool for life science research, in particular, disease research, personalized medicine, plant research and many others. The technique has expanded to other adjacent areas such as drug safety (toxicity markers) screening in the pharmaceutical industry.
Metabolomics workflows have also proven to have applicability in several other industrial research areas, agriculture, food and nutrition, and environmental.
Mass spectrometry can be used to acquire data on thousands of metabolites in small and large-scale huOne example of such large-scale profiling is the HUSERMET project.
Metabolomics research is widely being used today to discover putative cancer biomarkers; to better understand its complex heterogeneous nature, to discover pathways involved in cancer that could be used for new targets and to monitor metabolic biomarkers during therapeutic intervention. It can also be applied to understanding more fundamental mechanistic insights into cancer and carcinogenesis.
Environmental metabolomics analyzes the effects of disease and chemicals on organisms. Applications include environmental monitoring of sentinel species, chemical risk assessment of pharmaceutical, pesticides and other chemicals and maintenance of healthy livestock and fish.
Food metabolomics enables valuable information about the biochemical composition or profile of foods to be rapidly obtained. This profile contains components for flavors and shelf life and so this information will enable control over food quality, authenticity, as well as research into flavor development.
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