Comprehensive lipidomics solutions
Lipidomics is a field of metabolomics that has evolved into a class all its own and aims to map and quantify lipid species sets within a cell or tissue to identify biomarkers and elucidate metabolism at the cellular level. Lipid species are diverse and complex, and the development of HRAM Orbitrap MS has risen to the challenge of lipid analysis, offering an unprecedented level of sensitivity, selectivity and precision.
Untargeted lipidomics becomes as routine as proteomics identification with the Thermo Scientific™ Q Exactive™ HF hybrid quadrupole-Orbitrap mass spectrometer. Perform simultaneous identification and relative quantitation with this system's industry-leading HRAM Orbitrap MS, which can be combined with Thermo Scientific™ LipidSearch™ Software for more confident and accurate annotation.
The Thermo Scientific™ Orbitrap Fusion™ Lumos™ Tribrid™ mass spectrometer offers workflows that enable full characterization of isomeric lipids and high throughput HRAM MS profiling. This system's advanced MSn capabilities, flexible fragmentation modes and resolution of 500,000 FWHM provide more complete isomer identification and structural characterization.
For routine and well characterized lipids, the Thermo Scientific™ TSQ Quantiva™ triple quadrupole mass spectrometer exceeds even the most stringent analytical requirements with superb sensitivity, speed and dynamic range for SRM-based targeted lipidomics applications.
The Thermo Scientific™ LipidSearch™ software processes both HRAM Orbitrap and SRM triple quadrupole data, for the automatic identification and quantification of cellular lipids. It automatically generates reports from complex data to dramatically reduce analysis time.
Thermo Scientific™ TraceFinder™ software makes the challenging steps of unknown screening and targeted quantitation of lipids simple, fast and productive. It can be used with the full portfolio of Thermo Scientific quantitative mass spectrometers (both HRAM and triple quadrupole).