White paper

 

Challenges and Emerging Directions in Single-Cell Proteomics

Will It Go Mainstream Like Genomics?

Proteomics has seen many advances over the last decade from improvements in mass spectrometry instrumentation to an expansion of new workflows and applications. The promise of single-cell proteomics has been a topic frequently discussed over the last 10 years, with the hope it becomes a reality.

Download the white paper to learn about the challenges of single-cell proteomics, new technologies that address these challenges, improvements and the outlook for single-cell proteomics.

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Webinars

 

One cell at a time:
Single cell proteomics becomes a reality

Dr. Ryan Kelly, Associate professor, Chemistry and Biochemistry, Brigham Young University.

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Multiplexed single cell proteomics:
A marriage of sensitivity and throughput

Dr. Erwin Schoof, Head of Proteomics Facility,
Technical University of Denmark Postdoctorial Fellow, Copenhagen University

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One cell at a time:
Single cell proteomics becomes a reality

Dr. Ryan Kelly, Associate professor, Chemistry and Biochemistry, Brigham Young University.

Watch on-demand 

Multiplexed single cell proteomics:
A marriage of sensitivity and throughput

Dr. Erwin Schoof, Head of Proteomics Facility,
Technical University of Denmark Postdoctorial Fellow, Copenhagen University

Watch on-demand

Resources

 

Recommended products

 

Orbitrap Exploris 480 Mass Spectrometer

Obtain maximum quantitative insights with industry-leading single-cell sensitivity and extraordinary accuracy, precision and simplicity. With curated workflows that deliver greater usability, the Thermo Scientific Orbitrap Exploris 480 mass spectrometer accelerates your path to large scale studies, delivering maximum insights from limited samples and single-cells, with proven high data quality and time savings, so you can go beyond faster to actionable outcomes.

Learn more

Orbitrap Eclipse Tribrid Mass Spectrometer

With innovations that deliver maximum sensitivity and throughput, the Thermo Scientific Orbitrap Eclipse Tribrid mass spectrometer allows you to move away from bulk sample to rare cell and single-cell proteomics analysis. In combination with TMT multiplexing reagents and the FAIMS Pro Interface, we deliver more proteins per cell, profiling and quantifying proteins from tens to hundreds of cells per day, generating maximum insights that assess cell heterogeneity and rare cell type, so you can go beyond faster to biological discoveries.

Learn more

FAIMS Pro Interface

Achieve superior selectivity and enable more proteins to be identified while reducing time-consuming sample preparation steps with the next generation differential ion mobility Thermo Scientific FAIMS Pro interface. It reduces singly charged chemical noise and matrix interferences, resulting in the enhancement of peptide ions maximizing the sensitivity needed for single cell proteomics analysis.

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TMTpro 16plex Label Reagent Set

Thermo Scientific Tandem Mass Tag Reagents are designed to enable identification and quantitation of proteins in different samples using tandem mass spectrometry. To increase throughput for single-cell proteomics analysis, the new TMTpro 16plex label reagent set delivers the ability to analyze more than 100 single cells per day per HRAM Tribrid MS instrument with the use of a booster channel to maximize sensitivity needed for single-cell analysis.

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