Comprehensive proteomics analysis

To better understand the functions of individual proteins and their place in complex biological systems, it is necessary to measure changes in protein abundance relative to those of the system. As a result, modern proteomics has shifted from its initial qualitative outlook and currently encompasses a continuum of qualitative and quantitative technologies and approaches.

To make sense of the growing complexities of both qualitative and quantitative analysis, the field of proteomics demands state-of-the-art sample preparation techniques, analytical technologies, and software solutions. Our proven scientific network, publications, and pioneering solutions, which are driven by Thermo Scientific high-resolution accurate-mass (HRAM) Orbitrap mass spectrometers, enable broader and deeper analysis into the proteome than ever before. Our industry-leading breadth in liquid chromatographic separations, combined with the technical depth of our mass spectrometry (MS) systems and consumables, together produce novel, stringent, and reproducible results for high-impact discoveries.


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Our comprehensive portfolio of chromatographic separations chemistries and consumables offer powerful solutions for the analysis of complex biological samples, including proteins, peptides and challenging posttranslational modifications (PTMs).

Mass spectrometry calibration solutions are ready-to-use liquid formulations that can quickly calibrate LC-MS instrumentation. Validated standards are available for sensitivity assessment, determination of digestion efficiency, or as a control for complex sample analysis.

Learn more about our reagents, assays, kits and columns that enable robust and reproducible protein extraction from different samples, as well as peptide digestion, enrichment, and clean-up for mass spectrometry analysis.

Our leading Orbitrap-based MS systems, combined with advanced separations technology, provide the fast data acquisition and multiple fragmentation options required for complex proteomics experiments, maximizing productivity during single-run analysis.

Analysis of proteomics experimental data ranges from mass spectra identification to quantitation to extraction of meaningful biological information. Thermo Fisher Scientific offers a suite of proteomics software products that enable you to quickly transform complex data into meaningful results.

Our workflows combine different biological sample processing kits with highly sensitive yet powerful instrumentation and integrated software platforms. This results in accurate and reproducible mass spectrometry data from targeted as well as untargeted analysis experiments.


Proteomics and protein mass spectrometry workflow


Proteomics and protein MS videos