Oligonucleotide and Amino Acid Analysis

Complete characterization of nucleotide-based pharmaceuticals

Nucleotide-based pharmaceuticals are well established and represent an important class of clinically important drugs. Despite being highly efficient, the synthesis and development of these molecules can be prone to process-related impurities and modifications. Complete characterization is, therefore, important throughout their developmental and manufacturing processes.

Our chromatography columns demonstrate selectivity and support resolution for separation of therapeutic and diagnostic oligonucleotides and their derivatives. 

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Popular oligonucleotide and amino acids analysis products
Oligonucleotide and amino acids analysis categories
DNAPac RP Columns

Achieve superior reversed-phase oligonucleotide separations using Thermo Scientific DNAPac RP HPLC columns. The unique chemistry is designed for analysis of oligonucleotides and double-stranded (ds) DNA/RNA fragments using LC-UV or LC-MS. The column chemistry provides excellent performance under a broad range of pH, temperature, and mobile phase compositions. In addition, the wide pore size of the resin provides excellent separation of large double-stranded nucleic acids up to 10k base pairs.


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Troy Voelker of Covance discusses why they chose the Q Exactive systems for HRAM MS bioanalysis of oligonucleotides and other novel therapeutics.


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DNAPac Family of Columns – Superior Oligonucleotide Analysis
DNAPac Family of Columns: Superior Oligonucleotide Analysis

Nucleic acid analysis is important for characterization of therapeutics, amplification primers or reporters, sequencing libraries, and aptamers. Variants can originate from synthetic errors, metabolic processing, and chemical degradation. Where oligonucleotide purity is critical, chromatographic purity analyses have proved invaluable.

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