Human mesenchymal stem cell expressing microtubule via BacMam gene delivery technology

Our Custom Biology Services team can help simplify the task of generating custom cell lines, parental cell lines and high-throughput–ready cells. Using our robust genome editing and cell engineering technologies and expertise, we can help build the tools you need to create more relevant disease models for your project in a matter of weeks.

NEW Ask us today about our expanded, large knock-in capabilities—now for any cell type

Send us an inquiry to start your project

Advantages of working with our custom services team:

  • Free up valuable resources—outsourcing of key activities can help you accomplish your project goals
  • Extensive experience—we have genome edited 100+ cell lines and completed over 500 projects using the Invitrogen BacMam technology and Jump-In system
  • Dedicated project managers—our project management team provides dedicated support at every stage of your project

Complete your cell engineering projects in far less time by collaborating with our Custom Biology Services team. Whether your research requires custom engineered cell lines, Jump-In parental cell lines or BacMam virus particles, Thermo Fisher Scientific has the in-house expertise to support and accelerate your cellular projects.

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Genome editing for custom cell line generation

Cell line engineering service leverages one of the most robust and reliable technologies on the market. Utilizing quality products throughout the process, our scientists will work with you to design your stable cell line and perform quality control testing to help ensure that the cell line meets your requirement

Using either CRISPR-Cas9 or TAL effectors as genome-editing tools, we offer a variety of modification options including knock-out and knock-in (SNPs, large donor) for stable cell line generation in a wide variety of cell backgrounds. We have experience working everything from easy-to-transfect cell lines (including HEK 293, 293FT, HCT116, or HeLa) to hard-to-transfect cell lines (including iPSCs, fibroblasts, neuroblastoma-derived, hepatocellular carcinoma, bone marrow–derived, and endothelium-derived cells). How rapidly we can deliver a custom stable pool or stable cell line depends on the cell line, growth characteristics and culturing requirements. Stable cell line engineering services can be completed in as little as 10 weeks. 

For more information, see Stem Cell Genome Editing and Cell Line Engineering Services.
 

Jump-In parental cell line generation service

Access stable, isogenic mammalian cell lines faster with our Jump-In cell engineering service. Using the Jump-In platform, we can help accelerate your projects through the rapid generation of Jump-In parental cell line in less than 5 weeks. Jump-In technology enables the rapid generation of a pool of cells with a gene of interest integrated at a single genomic locus using targeted integration using R4 integrase. Simply provide us with the target gene mutation of interest and select from an existing parental Jump-In cell lines to create a stable pool that expresses the gene of interest. Jump-In stable pool can be available in as little as 5 weeks.

For more information on our Jump-In service, submit an online inquiry

See how researchers are leveraging the Jump-In system to achieve their research goals:

BacMam virus generation

Our BacMam virus generation service enables production of baculovirus for an efficient, convenient and safe method for gene delivery to transiently express targets of interest. The BacMam virus system offer several key advantages:

  • Efficient transduction of mammalian cell lines, including primary cells and stem cells
  • Safety (non-replicating in mammalian cells) and lack of observable cytopathic effect
  • Frozen storage of pre-transduced cells generates assay-ready cells

Our capabilities range from generating BacMam virus from your gene of interest in as quickly as 5 weeks, to full assay development and batch transduction of your BacMam virus into your cell line of choice.

Interested in custom BacMam virus generation or building an assay for your target? For more information on custom BacMam projects, submit an online inquiry or email us.

See how researchers have successfully leveraged the BacMam technology to enable their research:

Cell banking

Obtain validated, high-throughput screening-ready cells in scale more efficiently with our cryopreservation service. Our standardized, high-quality process yields validated cell lines typically within 2  to 4 weeks.

The process is simple:

  1. Provide us your cell line or purchase one of our cell lines
  2. Our scientists scale-up and produce cryopreserved cells
  3. Cell lines are quality control-tested and validated

For more information on our cell banking services, submit an online inquiry or email us


Custom Biology Services team

With many labs facing resources restraints, our Custom Biology team offers institutions a powerful resource to extend their research teams.  Wholly dedicated to developing custom tools and assays, the team has the expertise to select an assay technology from the extensive Thermo Fisher Scientific toolbox and use these technologies to craft tools that meet your unique requirements.

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Dedicated project management

From your initial inquiry through every milestone of your project, you can expect exceptional service and frequent, proactive communication from a dedicated project manager.  Your project manager will help ensure all parties involved in the project are aligned on project requirements, timelines and budgets.

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