Our latest research findings in drug discovery and ADME/Tox are illustrated through posters presented at conferences like SBS, AACR and others; and through peer-reviewed articles. View some of our most recent publications in the table below.

Title Authors Reference
A Fluorescence Polarization Assay for the Muscarinic M1 G-protein Coupled Receptor  KG Huwiler, T De Rosier, BJ Hanson, KW Vogel. Assay Drug Dev Technol. 2010 Jun;8(3):356-66.
Multi-Pathway Cellular Analysis of Compound Selectivity Michael K. Hancock, Connie S. Lebakken, Jun Wang, Kun Bi Mol Biosyst. 2010 Oct 1;6(10):1834-43.
ADP Detection Technologies Lowery RG, Vogel K, Till J. Assay Drug Dev Technol. 2010 Aug;8(4):1-2
Development and Validation of a Cell-Based Assay for the Nuclear Receptor Retinoid-Related Orphan Receptor Gamma Wilkinson J, Hallis T, Hermanson S, Bi K Assay Drug Dev Technol. 2010 Nov 4. [Epub ahead of print]
Commentary: Prioritizing hits based on drug-target residence time Vogel KW Drug Discovery News, Sept 2010, p13
Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors. De SK, Chen V, Stebbins JL, Chen LH, Cellitti JF, Machleidt T, Barile E, Riel-Mehan M, Dahl R, Yang L, Emdadi A, Murphy R, Pellecchia M. Bioorg Med Chem. 2010 Jan 15;18(2):590-6.
Covalent peroxisome proliferator-activated receptor{gamma} binding by nitro-fatty acids: Endogenous ligands act as selective modulators. Schopfer FJ, Cole MP, Groeger AL, Chen CS, Khoo NK, Woodcock SR, Golin-Bisello F, Motanya UN, Li Y, Zhang J, Garcia-Barrio MT, Rudolph TK, Rudolph V, Bonacci G, Baker PR, Xu HE, Batthyany CI, Chen YE, Hallis TM, Freeman BA. J Biol Chem. 2010 Apr 16;285(16):12321-33.
Multiplexing terbium- and europium-based TR-FRET readouts to increase kinase assay capacity. Vogel KW, Horton R J Biomol Screen. 2010 Sep;15(8):1008-15.
Differential effects of allosteric M(1) muscarinic acetylcholine receptor agonists on receptor activation, arrestin 3 recruitment, and receptor downregulation. Davis AA, Heilman CJ, Brady AE, Miller NR, Fuerstenau-Sharp M, Hanson BJ, Lindsley CW, Conn PJ, Lah JJ, Levey AI. ACS Chem Neurosci. 2010 Aug 18;1(8):542-551.
Development of a GPR23 cell-based β-lactamase reporter assay. Lee PH, Hanson BJ. Methods Enzymol. 2010;485:349-68
Measurement of the cellular deacetylase activity of SIRT1 on p53 via LanthaScreen® technology.
Robers MB, Loh C, Carlson CB, Yang H, Frey EA, Hermanson SB, Bi K. Mol Biosyst. 2011 Jan 1;7(1):59-66.
TR-FRET Cellular Assays for Interrogating Posttranslational Modifications of Histone H3 Thomas Machleidt, Matthew B. Robers, Spencer B. Hermanson, Jeanne M. Dudek, Kun Bi J Biomol Screen December 2011 vol. 16 no. 10 1236-1246
A Substrate-Independent TR-FRET Histone Deacetylase Inhibitor Assay Bryan D. Marks, Stephen A. Fakhoury, William J. Frazee, Hildegarde C. Eliason, Steven M. Riddle J Biomol Screen December 2011 vol. 16 no. 10 1247-1253
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