Our latest research findings in drug discovery and ADME/Tox are illustrated through posters presented at conferences like SBS, AACR and others; and through peer-reviewed articles. View some of our most recent publications in the table below.

A Fluorescence Polarization Assay for the Muscarinic M1 G-protein Coupled Receptor  KG Huwiler, T De Rosier, BJ Hanson, KW Vogel.Assay Drug Dev Technol. 2010 Jun;8(3):356-66.
Multi-Pathway Cellular Analysis of Compound SelectivityMichael K. Hancock, Connie S. Lebakken, Jun Wang, Kun BiMol Biosyst. 2010 Oct 1;6(10):1834-43.
ADP Detection TechnologiesLowery RG, Vogel K, Till J.Assay Drug Dev Technol. 2010 Aug;8(4):1-2
Development and Validation of a Cell-Based Assay for the Nuclear Receptor Retinoid-Related Orphan Receptor GammaWilkinson J, Hallis T, Hermanson S, Bi KAssay Drug Dev Technol. 2010 Nov 4. [Epub ahead of print]
Commentary: Prioritizing hits based on drug-target residence timeVogel KWDrug Discovery News, Sept 2010, p13
Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors.De SK, Chen V, Stebbins JL, Chen LH, Cellitti JF, Machleidt T, Barile E, Riel-Mehan M, Dahl R, Yang L, Emdadi A, Murphy R, Pellecchia M.Bioorg Med Chem. 2010 Jan 15;18(2):590-6.
Covalent peroxisome proliferator-activated receptor{gamma} binding by nitro-fatty acids: Endogenous ligands act as selective modulators.Schopfer FJ, Cole MP, Groeger AL, Chen CS, Khoo NK, Woodcock SR, Golin-Bisello F, Motanya UN, Li Y, Zhang J, Garcia-Barrio MT, Rudolph TK, Rudolph V, Bonacci G, Baker PR, Xu HE, Batthyany CI, Chen YE, Hallis TM, Freeman BA.J Biol Chem. 2010 Apr 16;285(16):12321-33.
Multiplexing terbium- and europium-based TR-FRET readouts to increase kinase assay capacity.Vogel KW, Horton RJ Biomol Screen. 2010 Sep;15(8):1008-15.
Differential effects of allosteric M(1) muscarinic acetylcholine receptor agonists on receptor activation, arrestin 3 recruitment, and receptor downregulation.Davis AA, Heilman CJ, Brady AE, Miller NR, Fuerstenau-Sharp M, Hanson BJ, Lindsley CW, Conn PJ, Lah JJ, Levey AI.ACS Chem Neurosci. 2010 Aug 18;1(8):542-551.
Development of a GPR23 cell-based β-lactamase reporter assay.Lee PH, Hanson BJ.Methods Enzymol. 2010;485:349-68
Measurement of the cellular deacetylase activity of SIRT1 on p53 via LanthaScreen® technology.
Robers MB, Loh C, Carlson CB, Yang H, Frey EA, Hermanson SB, Bi K.Mol Biosyst. 2011 Jan 1;7(1):59-66.
TR-FRET Cellular Assays for Interrogating Posttranslational Modifications of Histone H3Thomas Machleidt, Matthew B. Robers, Spencer B. Hermanson, Jeanne M. Dudek, Kun BiJ Biomol Screen December 2011 vol. 16 no. 10 1236-1246
A Substrate-Independent TR-FRET Histone Deacetylase Inhibitor AssayBryan D. Marks, Stephen A. Fakhoury, William J. Frazee, Hildegarde C. Eliason, Steven M. RiddleJ Biomol Screen December 2011 vol. 16 no. 10 1247-1253

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