In vitro assays and screening technologies

At Life Technologies we have developed two pre-configured fluorescent assay solutions to address HTS, hit confirmation and lead optimization programs for nuclear receptor targets.

The core assay formats we have developed are:

  • NR Competitive Binding Assays
  • NR Coactivator Assays

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View the table below for a complete list of the biochemical assays offered for your nuclear receptor research.

If you do not see the target or assay format of your choice please contact us.

Nuclear Receptor Biochemical Assay Selection Table

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TargetAlias(es)Accession numberPolarScreen™ Nuclear Receptor Competitor Assay (Fluorescent Polarization)LanthaScreen® Competitive Binding Assay (TR-FRET)*LanthaScreen® Coactivator Assay (TR-FRET)*
Androgen receptor

AR, NR3C4

NP_036634 A15878
Constitutive androstane receptor
CAR, NR1I3NP_005113.1  PV4836
Estrogen receptor alphaER Alpha, ERA, ESR1, NR3A1NP_000116.2A15887A15885
Estrogen receptor beta

ER Beta, ERB, ESR2, NR3A2

NP_001428.1

A15895A15893
Estrogen-related receptor alpha

ERR Alpha, ERR1, ESRRA, ESRL1, NR3B1

NP_004442.2

  PV4663
Estrogen-related receptor beta

ERR Beta, ERR2,ESRRB, NR3B2

NP_004443.2  PV4800
Estrogen-related receptor gamma

ERR Gamma, ERR3, ESRRG, NR3B3

NP_001429  PV4408
Farnesoid X receptor

FXR,NR1H4

NP_005114.1  PV4833
Glucocorticoid receptor

GR, GCCR, GCR, NR3C1

NP_000167A15901A15899
Liver X receptor alpha

LXR Alpha, LXRA, NR1H3

NP_005684  PV4655
Liver X receptor beta

LXR Beta, LXRB, NR1H2

NP_009052  PV4658
Peroxisome proliferator-activated receptor alpha

PPAR Alpha, PPARA, NR1C1

NP_005027 PV4892PV4684
Peroxisome proliferator-activated receptor delta
PPAR Delta, PPARD, NR1C2NP_006229 PV4893PV4685
Peroxisome proliferator-activated receptor gamma
PPAR Gamma, PPARG, NR1C3NP_005028PV6136 -Green PV4894PV4548
Pregnane X receptor
PXR(SXR), NR1I2NP_003880.3 PV4839 
Progesterone receptor
PR, PGR, NR3C3NP_000917.2 A15903
Retinoic acid receptor alpha
RAR Alpha, RARA, NR1B1NP_000955  PV4409
Retinoic acid receptor beta
RAR Beta, RARB, NR1B2NP_000956  PV4688
Retinoic acid receptor gamma
RAR Gamma, RARG,NR1B3NP_000957  PV4411
Retinoid-related Orphan Receptor alpha

ROR Alpha, RORA, NR1F1

NP_599023.1  PV5889
Retinoid X receptor alpha

RXR Alpha, RXRA, NR2B1

NP_002948.1  PV4797
Retinoid X receptor beta
RXR Beta, RXRB, NR2B2NP_068811  PV4385
Thyroid receptor alpha
TR Alpha, THRA, NR1A1NP_955366.1  PV4687
Thyroid receptor beta

TR Beta, THRB, T3RB, NR1A2

NP_000452.2  PV4686
Vitamin D3 receptor

VDR, NR1I1

NP_000367

A15907 - Red

 PV4554

Other LanthaScreen® Fluorescent Coregulator Peptides are available for your development of additional coactivator or corepressor assays. 

For research use only. Not intended for any animal or human therapeutic or diagnostic use.
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