Identify the right drug candidates

Identify the right drug candidates

Thermo Scientific twin-screw extruders are built with similar geometries. This enables experimentation and feasibility projects with a lab-scale (11 mm screw) extruder that minimizes the use of expensive APIs and enables easy clean-up between experiments.

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With a minimum throughput of 20 g/h, a benchtop extruder is ideal for Phase 1 research applications, especially when developing and testing recipes with expensive API and associated compounds. As a GMP-compliant unit, the Thermo Scientific Pharma 11 is also suitable for clinical trials and small-scale production for throughputs up to 2.5 kg/h. The screw and barrel designs are geometrically scalable across the whole Thermo Scientific portfolio of extruders from lab and pilot through to production scale.

For consistent, controllable processing of hot melt drug formulations that are suitable for PAT, the 24mm twin screw extruder promises reduced product changeover time, minimized scale-up risk and easy cleaning.

This platform includes a number of integrated ancillary equipment for both project development and small-scale production including pre-mixers, feeders, chill rolls, air-cooled conveyors, pelletizers, and cast sheet or blown film lines. GMP standard pharmaceutical versions of the ancillaries are available with stainless steel construction and dust-tight touch-screen operator interface.


Thermo Scientific Pharma Twin-screw Extruder Selection Guide

Quickly find the right Pharma twin-screw extruder to fit your formulation development and production needs.

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Pharma Twin-Screw Extruders Pharma Mini HME Pharma 11 Pharma 16 Pharma 24 Pharma 24 TSG
Recommended for Feasibility Research Research/Pilot Manufacturing Manufacturing
Typical throughput HME* 3 g batch or 100 g/h 20 g/h - 2.5 kg/h 0.5 kg/h - 10 kg/h 1 kg/h - 30 kg/h N/A
Typical throughput TSG* N/A up to 3 kg/h up to 20 kg/h up to 80 kg/h up to 80 kg/h
Dimensions
(L × W × H)
58 x 37 x 34 cm 83 x 48 x 41 cm 210 x 76 x 176 cm 210 x 85 x 173 cm 195 x 32 x 42 cm
Downstream Options take-off belt
laser based calibration and cutting device
conveyor belt
pelletizer
sheet take-off
conveyor belt
pelletizer
chill-roll
face cut pelletizer
conveyor belt
pelletizer
chill-roll
face cut pelletizer
for line integration
Screw Design conical, co- counter rotating parallel, co-rotating parallel, co-rotating parallel, co-rotating parallel, co-rotating
Max. Torque 5 Nm 6 Nm / shaft 18 Nm / shaft 52.5 Nm / shaft 18 Nm / shaft

*actual throughput dependent on formulation

Download this selection guide as a pdf

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