Identify the right drug candidates

Identify the right drug candidates

Thermo Scientific twin-screw extruders are built with similar geometries. This enables experimentation and feasibility projects with a lab-scale (11 mm screw) extruder that minimizes the use of expensive APIs and enables easy clean-up between experiments.

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For consistent, controllable processing of hot melt drug formulations that are suitable for PAT, the 24mm twin screw extruder promises reduced product changeover time, minimized scale-up risk and easy cleaning.

This platform includes a number of integrated ancillary equipment for both project development and small-scale production including pre-mixers, feeders, chill rolls, air-cooled conveyors, pelletizers, and cast sheet or blown film lines. GMP standard pharmaceutical versions of the ancillaries are available with stainless steel construction and dust-tight touch-screen operator interface.


Thermo Scientific Pharma Twin-screw Extruder Selection Guide

Quickly find the right Pharma twin-screw extruder to fit your formulation development and production needs.

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Pharma Twin-Screw Extruders Pharma Mini HME Pharma 11 Pharma 16 Pharma 24 Pharma 24 TSG
Recommended for Feasibility Research Research/Pilot Manufacturing Manufacturing
Typical throughput HME* 3 g batch or 100 g/h 20 g/h - 2.5 kg/h 0.5 kg/h - 10 kg/h 1 kg/h - 30 kg/h N/A
Typical throughput TSG* N/A up to 3 kg/h up to 20 kg/h up to 80 kg/h up to 80 kg/h
Dimensions
(L × W × H)
58 x 37 x 34 cm 83 x 48 x 41 cm 210 x 76 x 176 cm 210 x 85 x 173 cm 195 x 32 x 42 cm
Downstream Options take-off belt
laser based calibration and cutting device
conveyor belt
pelletizer
sheet take-off
conveyor belt
pelletizer
chill-roll
face cut pelletizer
conveyor belt
pelletizer
chill-roll
face cut pelletizer
for line integration
Screw Design conical, co- counter rotating parallel, co-rotating parallel, co-rotating parallel, co-rotating parallel, co-rotating
Max. Torque 5 Nm 6 Nm / shaft 18 Nm / shaft 52.5 Nm / shaft 18 Nm / shaft

*actual throughput dependent on formulation

Download this selection guide as a pdf

Have questions? Request to talk with a Pharma extruder expert.