Simple, flexible, and cost‑efficient vaccine research and development

Accelerating the research and development of mRNA vaccines requires simple workflows with all inputs optimized for product needs. The demand for high-quality mRNA purification and synthesis must be met with flexible and scalable solutions. Invitrogen Dynabeads Streptavidin for In Vitro Transcription and Invitrogen Dynabeads Carboxylic Acid for RNA Purification are specifically designed for optimal mRNA synthesis and purification.

Dynabeads magnetic beads for mRNA vaccine research and development offer:

  • Reusability—reuse the DNA template up to six times, minimizing plasmid prep and reducing hands-on time and risk of transfer of bacterial host DNA
  • Automation—enable high‑throughput synthesis and purification of many samples simultaneously
  • Flexibility—choice of synthetic or plasmid DNA template to enable mRNA IVT for greater flexibility of mRNA design

Dynabeads Streptavidin for In Vitro Transcription

An innovative solution facilitating the reuse of DNA template, minimizing the effort needed for plasmid preparation whilst maximizing the mRNA productivity in scale ranging from µg to g quantities of mRNA.

RNA is synthesized using a biotinylated DNA template of choice, amplified through PCR, immobilized to Dynabeads Streptavidin for In Vitro Transcription. The immobilized template can be reused in the next IVT reaction (at least six times).

Cell culture volumes will be approximately 10,000 times smaller than traditional In Vitro Transcription (IVT) workflows. The highly efficient Dynabeads IVT process delivers exceptional quality mRNA in scalable quantities that can flex quickly and easily according to your needs.

Diagram illustrating mRNA synthesis

Dynabeads Carboxylic Acid for RNA Purification

Synthesized mRNA is captured at high quality in a volume of choice in a simple bind-wash-elute process.

Diagrammed steps of RNA Purification

For Research Use Only. Not for use in diagnostic procedures.

Dynabeads mRNA production solutions and quality requirements*

Our proprietary magnetic bead technology, experience, and capabilities help to accelerate the commercialization of your mRNA vaccines and therapeutics by streamlining the development and manufacturing process, from prototype batches to bulk manufacture, enabling high bead performance and security of supply.

Dynabeads mRNA production solutions offer*:

  • Minimized footprint—enable modular manufacturing to cost-effectively match required scale (increase or decrease)
  • Support—platform designed for optimal product quality and regulatory support, including published data and technical support for vaccine development and manufacturing
  • Quality—safe, flexible supply of magnetic beads for vaccine developers, from development to commercial manufacturing scale, without incurring extra time or costs from switching technology or raw materials

With 35+ years' experience in designing, developing, and manufacturing paramagnetic beads to internationally recognized quality standards, our Dynabeads specialists have collaborated with leading biotech, pharma, and healthcare companies provide optimized and validated Dynabeads under custom OEM supply arrangements.

By working with mRNA production solutions, drug developers and vaccine manufacturers gain access to unique solutions for mRNA synthesis and purification with optimized workflows and flexible supply of rigorously controlled high-quality products. The products are specifically designed for this purpose, enabling seamless and GMP-compliant scale-up of mRNA production—from pre-clinical and toxicology studies to process development and optimization to clinical and commercial manufacturing.

Invitrogen Dynabeads Streptavidin for In Vitro Transcription and Invitrogen Dynabeads Carboxylic Acid for RNA Purification are supported by a comprehensive quality system and documentation, including:

  • Manufacturing in compliance with ISO 20399, ISO 13485, and 21 CFR820
  • Animal origin–free (AOF) manufacturing process/equipment and raw materials 
  • Validated manufacturing processes and analytical methods
  • Product-specific stability data
  • Impurity profile
  • Verified compendial test methods, where applicable 
  • Manufactured in β-lactam–free facilities
  • Quality support documents available including CoA, COO, TSE/BSE statement, nitrosamine statement, melamine statement, etc.

Ordering information

Catalog #Name    SizePrice
Dynabeads Streptavidin for In Vitro Transcription*
100 mL, 10 mg/mL Contact us
49011D10 mL, 10 mg/mL Contact us
Dynabeads Carboxylic Acid for RNA Purification*
100 mL, 10 mg/mL Contact us
49021D10 mL, 10 mg/mL Contact us

*For research use or further manufacturing. Not for diagnostic use or direct administration into humans or animals.