Accelerating the research and development of mRNA vaccines requires simple workflows with all inputs optimized for product needs. The demand for high-quality mRNA purification and synthesis must be met with flexible and scalable solutions. Invitrogen Dynabeads Streptavidin for In Vitro Transcription and Invitrogen Dynabeads Carboxylic Acid for RNA Purification are specifically designed for optimal mRNA synthesis and purification.
An innovative solution facilitating the reuse of DNA template, minimizing the effort needed for plasmid preparation whilst maximizing the mRNA productivity in scale ranging from µg to g quantities of mRNA.
RNA is synthesized using a biotinylated DNA template of choice, amplified through PCR, immobilized to Dynabeads Streptavidin for In Vitro Transcription. The immobilized template can be reused in the next IVT reaction (at least six times).
Cell culture volumes will be approximately 10,000 times smaller than traditional In Vitro Transcription (IVT) workflows. The highly efficient Dynabeads IVT process delivers exceptional quality mRNA in scalable quantities that can flex quickly and easily according to your needs.
Synthesized mRNA is captured at high quality in a volume of choice in a simple bind-wash-elute process.
For Research Use Only. Not for use in diagnostic procedures.
Our proprietary magnetic bead technology, experience, and capabilities help to accelerate the commercialization of your mRNA vaccines and therapeutics by streamlining the development and manufacturing process, from prototype batches to bulk manufacture, enabling high bead performance and security of supply.
With 35+ years' experience in designing, developing, and manufacturing paramagnetic beads to internationally recognized quality standards, our Dynabeads specialists have collaborated with leading biotech, pharma, and healthcare companies provide optimized and validated Dynabeads under custom OEM supply arrangements.
By working with mRNA production solutions, drug developers and vaccine manufacturers gain access to unique solutions for mRNA synthesis and purification with optimized workflows and flexible supply of rigorously controlled high-quality products. The products are specifically designed for this purpose, enabling seamless and GMP-compliant scale-up of mRNA production—from pre-clinical and toxicology studies to process development and optimization to clinical and commercial manufacturing.
Invitrogen Dynabeads Streptavidin for In Vitro Transcription and Invitrogen Dynabeads Carboxylic Acid for RNA Purification are supported by a comprehensive quality system and documentation, including:
*For research use or further manufacturing. Not for diagnostic use or direct administration into humans or animals.