Learning Resources for mRNA Production
Browse through our curated selection of learning resources to enable your success in development of mRNA therapeutics and vaccines. View available technical assets related to raw materials for mRNA production, process development using in vitro transcription, scale-up synthesis of mRNA, and more. Find the information and resources you need by looking through our scientific content below.
Read about the prospects of the mRNA technology, tips on scaling up mRNA production, and analytical solutions for mRNA vaccines and therapeutics.
Read about expert views on mRNA development and manufacturing, advantages of mRNA processes, and best practices for scale up of in vitro transcription for mRNA production.
In ~10 months, Thermo Fisher Scientific drastically scaled up raw material manufacturing for mRNA production, from concept to clinical development and on to industrial-scale production.
Thermo Fisher Scientific quickly developed and executed manufacturing processes to deliver animal origin-free (AOF) enzymes at scale to a biopharmaceutical client.
Review the mRNA production process and some critical considerations for choosing raw materials to support clinical manufacturing efforts.
Understand how your processes and material usage strategy during the development phase could impact your manufacturing processes and regulatory approval downstream.
Enable agility in your process from vaccine development to manufacture with one technology designed for flexible mRNA synthesis and purification.
Collaboration, innovation, and partnership are key to more efficient, accessible, and scalable mRNA technology.
Pay attention to process robustness, raw materials, and how partners can help at the very beginning of the journey of mRNA drug development.
Learn why raw materials matter in the development and manufacturing of mRNA vaccines and therapeutics.
Is GMP grade good enough? What mRNA manufacturers need to know when buying raw materials.
Find five tips on scaling up in vitro transcription for mRNA production in the development and manufacturing of mRNA vaccines and therapeutics.
By using design of experiments (DoE) principles and analytics, a variety of IVT reaction conditions were assessed for their impact on the IVT reactions.
A closed system based on single-use technology was used to drastically minimize the risk of contamination inherent to the conventional manufacturing process of IVT enzymes.
A new cap analog was synthesized and evaluated for its translational performance against the standard trinucleotide cap and anti-reverse cap analog.
Read about an analysis of some of the key product quality attributes of a modified nucleotide product, and their impact on the development and manufacturing of a therapeutic.
Read about the importance of quality of nucleoside triphosphates (NTPs) that are used for the production of mRNA therapeutics.
Examine why raw materials are crucial for mRNA production and learn solutions to overcome mRNA production challenges.
Discover the benefits of a magnetic bead–based modular approach for mRNA production.
Learn about key considerations in mRNA synthesis and scale-up to help you accelerate research and development of mRNA vaccines and therapeutics.
For Research Use or Further Manufacturing. Not for diagnostic use or direct administration into humans or animals.