NanoDrop Spectrophotometer | What is NanoDrop

Trusted by Scientists Worldwide

The Thermo Scientific NanoDrop Spectrophotometer makes the analysis of sample concentration and purity routine, reproducible, and reliable, making it part of the daily routine in labs around the world. When you can stop worrying about sample purity, you can start making educated decisions about your samples for downstream experiments.

NanoDrop Spectrophotometer Innovations

For a greater measure of confidence

For more than 20 years, the game-changing Thermo Scientific NanoDrop Spectrophotometer has continually evolved to meet the changing needs of scientists like you. This legacy of customer-informed innovation has led to a rich history of reliability, robustness, ease of use, and expert service and support helping scientists make informed decisions and accelerating the pace of discovery.

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You spoke, we listened: Updates and innovations to the NanoDrop Spectrophotometer

NanoDrop Spectrophotometers are continuously updated with innovative features you told us you need.

  • Thermo Scientific Acclaro Sample Intelligence Technology enables early identification of contaminants to help you prevent failure of downstream applications, saving days of troubleshooting.
  • Software enables regulatory compliance (21 CFR Part 11), providing you with tools like user account access, audit trail capability, electronic signatures, automated data back-up, and more.
  • RNA/DNA differentiation, enabled by improved algorithms, allows you to separate mammalian DNA from RNA and vice versa in dsDNA/RNA applications.

This all takes us to today. While offering fewer features than our premium models, the new, entry-level NanoDrop Lite Plus Spectrophotometer gives teaching and academic research labs the opportunity to experience the ease-of-use, reliability, and accuracy that has become synonymous with the NanoDrop platform.

Choose the NanoDrop Spectrophotometer that's right for your lab

 NanoDrop One/OneC Microvolume UV-Vis Spectrophotometer
NanoDrop Eight Spectrophotometer
NanoDrop Lite Plus Spectrophotometer
Full-spectrum microvolume UV-Vis measurements with a cuvette option in a single instrument

Higher throughput, full-spectrum microvolume UV-Vis measurements

Basic microvolume UV measurements with trusted robustness, ease of use, and accuracy
Measures 1-2 μL sample

Dynamic range (ng/μL dsDNA)2.027,500*
ng/μL for dsDNA
2.0 - 10,000
ng/μL for dsDNA
ng/μL for dsDNA
Full-spectral data

Pre-programmed methods for nucleic acids and proteins

Measures nucleic acid A260/A280 ratio

Measures nucleic acid A260/A230 ratio

Measures purified protein A280

Measures protein A260/A280 ratio

Standalone local control


Contaminant Identification


Autoblank & Automeasure


21 CFR Part 11 regulatory compliance

With optional softwareWith optional software 

NanoDrop Free Trial Program

Test a NanoDrop instrument in your laboratory with your own samples and convince yourself.