Browse cancer biology pathways
Cancer is a type of disease resulting from abnormal cell growth that has the possibility of metastasizing, or spreading to other parts of the body. Environmental toxins and genetic mutations can play a role in the development of tumors. Some of the most important pathways involved in cancer biology are the ErbB family pathway, the p53-mediated apoptosis pathway, and the GSK3 signaling pathway.
The immune system attempts to constrain tumor growth, but sometimes tumor cells might escape or attenuate this immune pressure.
The ErbB family of transmembrane receptor tyrosine kinases (RTKs) plays an important role during the growth and development of organs.
GSK3 is a ubiquitously expressed, highly conserved serine/threonine protein kinase found in all eukaryotes.
Tumor protein p53 is a nuclear transcription factor that regulates the expression of a wide variety of genes involved in apoptosis, growth arrest, or senescence in response to genotoxic or cellular stress.
Members of the transforming growth factor (TGF)-beta family play an important role in the development, homeostasis, and repair of most tissues.
The liver is a major site for the formation and metastasis of tumors.