We offer optimized reagents and kits based on immobilized papain, pepsin, and ficin proteases to selectively cleave IgG and IgM immunoglobulin molecules into Fab, Fab′, F(ab′)2 and Fc antibody fragments for use in immunodetection and immunoassay procedures.

Production of Fab fragments from intact antibodies using papain

Fab preparation kits

Digest human or mouse IgG antibodies with immobilized papain protease and purify Fab fragments using Protein A agarose.

Production of F(ab′)2 fragments from intact antibodies using pepsin

F(ab′)2 preparation kits

Selectively digest whole human and other IgG antibodies with immobilized pepsin protease to make F(ab′)2 fragments that retain antigen binding activity.

Production of Fab or F(ab′)2 fragments from intact mouse IgG1 using ficin

Mouse IgG1 Fab and F(ab′)2 preparation kits

Efficiently digest mouse IgG1 antibodies into Fab or F(ab′)2 fragments with immobilized ficin protease.


Partner with us to scale-up your process or product development pipeline with bulk quantities of high-quality immunoassay reagents and biochemicals. We offer a variety of compounds, devices, and resins for your large-scale applications.

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Guide to antibody purification
Protein quantitation immunoassays