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Study proteins implicated in neurodegenerative disorders

ELISA enables specific, quantitative measurements of protein from a variety of biological sources including serum, plasma, and CSF (cerebrospinal fluid) from a variety of species. We offer ELISA kits for the study of several proteins implicated in neurodegenerative disorders, such as:

  • Amyloid-beta (Aβ, beta amyloid or Abeta), which is crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of Alzheimer’s patients.
  • Tau, a protein which stabilizes microtubules and which, when not functioning properly, is implicated in pathologies and dementias of the nervous system.
  • Alpha synuclein (α-synuclein), which is thought to play an important role in maintaining a supply of synaptic vesicles in presynaptic terminals, and may also help regulate the release of dopamine.
Dynamic range for Invitrogen Human Tau ELISA Kit showing a range of 31–2,000 ng/ml and comparison of kit standard absorbance readings with natural human tau absorbance readings serially diluted.

Performance data for the Invitrogen Human Tau (Total) ELISA Kit (Cat. No. KHB0041). Left panel: Typical 7-point standard curve. The dynamic range is 31–2,000 pg/mL, with an analytical sensitivity of <12 pg/mL. Right panel: Kit recombinant human (Hu) tau protein standard compared to natural human tau serially diluted in Standard Diluent Buffer. The optical density of each dilution was plotted against the standard curve. Parallelism between the natural and recombinant protein indicates that the standard accurately reflects natural Hu tau content in samples.

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