Neurobiology Antibodies

We have a diverse array of highly specific antibodies for neuroscience research that have been validated* for multiple applications, including protein targets important in the study of glia, protein trafficking, neurogenesis, axon guidance, dendrite development, neuronal migration, growth factors, neuromuscular junction, neurotrophins, apoptosis, and synaptogenesis.

Download the Invitrogen Neurobiology Antibodies poster

Tau antibody immunohistochemistry image

Neurodegenerative disease research targets

Neurodegenerative research targets include cleavage specific antibodies to amyloid beta, phosphospecific, and pan antibodies against tau, parkin, LRRK2, nuclear aggregation of huntingtin (HTT) and MBP. Targeted neurodegenerative diseases include: Alzheimer’s disease, amyotrophic lateral sclerosis, Huntington’s disease, Multiple sclerosis, and Parkinson’s disease.

Markers of interest: beta amyloid, C9orf72, HTT, IL-17A, alpha synuclein

Synaptophysin antibody immunofluorescence image

Neuron markers

Neuron markers allow the specific identification of different neuronal cells in samples. Specific neuronal subtypes, like dopaminergic, glutamatergic and motor neurons express specific proteins that allow them to be specifically detected in imaging and flow cytometry experiments.

Markers of interest: ChAT, OTX2, GAD65, NMDAR2B, ISL2, calretinin

A2B5 antibody immunofluorescence image

Glial progenitor cell markers

Glial progenitor cells can be differentiated from neural stem cells, and then further differentiated into astrocytes and oliogodendrocytes. These progenitor cells are characterized by expression of CD44 and A2B5.

Markers of interest: A2B5, CD44

MAP2 antibody immunofluorescence image

Presynaptic and postsynaptic markers

Neuron communication involves the release of neurotransmitters from the presynaptic cells to the post synaptic cells. These cells express specific markers like synaptophysin (presynaptic) and PSD95 (postsynaptic) that allow for the differentiation of cell types.

Markers of interest: HOMER1, PSD95, synaptophysin, synaptotagmin, VGLUT1

GalC antibody immunofluorescence image

Oligodendrocyte progenitor cell and oligodendrocyte markers

Oligodendrocyte cells support and insulate neurons, creating the myelin sheath. They can be differentiated from glial progenitor cells. Important markers like GalC can be used to identify oligodendrocytes in a variety of applications and sample types.

Markers of interest: NG2, OLIG1, OLIG2, PDGFRA, MBP

Germlayer staining image

Neuroectoderm markers

Mammalian neurogenesis begins with the induction of neuroectoderm, which forms a neural plate and then folds to give rise to the neural tube. These structures are made up of a layer of neuroepithelial progenitors (NEPs).NEPs can be rapidly turned into primitive neural stem cells (NSCs).

Markers of interest: NCAM, SOX2, OTX2, PAX3, PAX6

Germlayer staining image

Neural stem cell markers

Neuronal stem cells are the first step in neuronal development from embryonic stem cells or induced pluripotent stem cells. The express important markers, nestin and SOX1 in addition to others. Neuronal stem cells can be further differentiated into glial progenitor cells and neuronal progenitor cells.

Markers of interest: SOX1, SOX2, PAX3, PAX6, FOXG1

Astrocytes stained cell image

Astrocyte markers

Astrocytes cells support the neural network. They express neurotransmitter receptors and may possibly play a role in neuronal communication. They express the important marker GFAP and can be differentiated from glial progenitor cells.

Markers of interest: ALDH1L1, EAAT2, GFAP, glutamine synthetase, S100beta

IBA1 antibody immunohistochemistry image

Microglia markers

Microglia play a major role in the immune system in the central nervous system, phagocytosing foreign material and cellular debris. Microglia can activate pro-inflammatory cytokines like, IFN-gamma, IL1-alpha, and TNF-alpha. Microglia also synthesize amyloid precursor protein (APP) in response to injury.

Markers of interest: CD11b, CD68, CX3CR1, HLA-DR, IBA1

*The use or any variation of the word “validation” refers only to research use antibodies that were subject to functional testing to confirm that the antibody can be used with the research techniques indicated. It does not ensure that the product(s) was validated for clinical or diagnostic uses.

We offer a diverse collection of Invitrogen products for imaging and dissecting neural networks and their functions, including neuronal tracers and neural anatomy and function probes. These dyes and stains are available in array fluorescent colors,giving you the flexibility to design your fluorescence imaging experiments.

Our Invitrogen products offer a broad technology platform for studying neural stem cells (NSC), providing you with innovative solutions that help enhance basic research and guide therapeutic discovery. These include neural stem cell antibodies, cell lines, media and reagents as well as neural stem cell growth factors and cytokines.