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Biologics improve the quality of life for humans and animals worldwide. Quality requirements, global supply needs and manufacturing efficiency are critical to biopharmaceutical manufacturers. Thermo Fisher Scientific brings decades of bioprocessing experience and knowledge, a collaborative customer-focused approach, performance-tested and reliable technologies, and products and services to drive your success.

 

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Over the past decade, gene therapy applications and their importance in the biopharmaceutical industry have been increasing. Gene therapies promise versatile treatment options that could revolutionize and transform medicine.

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SingleUseWhitePaper

It can take years to establish a pharmaceutical manufacturing plant; once it’s produced it then has to go through a vigorous testing process to ensure it meets industry standards. Implementing single-use technology can drastically reduce this time scale, making the production process much more efficient. 

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GasAnalysisMassSpecApplications

Fermentation is the term used by microbiologists to describe the production of a compound by means of the mass culture of a microorganism. This product can either be the cell itself (biomass production), the microorganism’s own metabolite or a foreign product. 

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Advantage of antibody based selectivity in the purification of biologics

Advances in biotherapeutics are generating an increasing range of complex molecules that present unique and often complex purification challenges. By taking advantage of antibody-based selectivity, Camelid heavy-chain antibody fragments (VHHs) have proven to be a reliable immuno affinity chromatography (IAC) solution in the downstream process of biologics. Thermo Scientific CaptureSelect affinity products and analytical tools are developed for the discovery and manufacturing of even the most demanding biotherapeutics. The affinity resins provide high target purity in a single step, independent of feedstock.

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Downstream Purification Solutions for Viral Vectors: Enabling Platform Approaches to Advance Cell
and Gene Therapies

Over the past decade, gene therapy applications and their importance in the biopharmaceutical industry have been increasing. Vectors centered on the nonpathogenic adeno-associated virus (AAV) have emerged as the vector of choice for many therapies. Although the biopharmaceutical industry is primed to purify viral vectors on a scale suitable for clinical supply or orphan indications, it is still working toward generating industrialized platform technologies that will maximize productivity and enable efficient, simple, and inexpensive purification of biologically active viral vectors for large-scale commercial manufacturing. Thermo Fisher Scientific has developed downstream purification solutions enabling the scale-up of these viral vectors.

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Single-step affinity purification of antibodies and antibody-fragments by Kappa light chain binding

With the development of novel biotherapeutic antibody formats, such as trifunctional and bi-specific monoclonal antibodies or antibody fragments, new purification challenges in the downstream process of these molecules arise. Thermo Scientific CaptureSelect antibody subdomain-specific affinity products are developed for the discovery and manufacturing of therapeutic antibodies and antibody fragments. The affinity resins provide high target purity in a single step, independent of feedstock. Here we show the performance of the CaptureSelect KappaXP affinity resin, a next generation Kappa Light chain binder, with improved dynamic binding capacity and mild elution properties, in comparison with alternative products.

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Accelerating antibody drug development with subdomain-specific affinity ligands

With the development of novel bio-therapeutic antibody formats, such as trifunctional and bi-specific monoclonal antibodies or antibody fragments, new purification challenges in the downstream process of these molecules arise. Thermo Scientific CaptureSelect antibody subdomain-specific affinity products and analytical tools are developed for the discovery and manufacturing of therapeutic antibodies and antibody fragments. The affinity resins provide high target purity in a single step, independent of feedstock.

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adv-antibody-based-thmb

Advances in biotherapeutics are generating an increasing range of complex molecules that present unique and often complex purification challenges. By taking advantage of antibody based selectivity, Camelid heavy-chain antibody fragments (VHHs) have proven to be a reliable immuno affinity chromatography (IAC) solution in the downstream process of biologics. Thermo Scientific CaptureSelect affinity products and analytical tools are developed for the discovery and manufacturing of even the most demanding biotherapeutics. The affinity resins provide high target purity in a single step, independent of feedstock.

Download poster

Featured bioproduction videos

See how Thermo Scientific customized fluid transfer systems can simplify adherent cell culture production.

The high scanning speeds and reproducible measurements make it ideal for process development laboratories that require a highly precise, multi-port magnetic sector gas analyzer. 

Bioproduction subtopics

Antibody and Cell Culture Information

The production of therapeutic antibodies and proteins is one of the fastest growing sectors of the pharmaceutical industry, where accuracy and consistency in bioprocessing can pose challenges.

Cellular and Stem Cell Information

Challenges in the production of cellular therapies are many, including safe navigation in a dynamic regulatory landscape, quality and consistency of processes, and safety and productivity, all in a cost-effective manner. 

Vaccine Information

As the global demand for vaccine doses dramatically increases, the need for highly efficient manufacturing processes, collaborative technical resources and a global supply partnership between vaccine producers and their suppliers is now an absolute necessity. 


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