Large Scale POROS bulk chromatography resins

What is process scale chromatography?

Process scale chromatography is a scalable GMP manufacturing technique for the separation of biomolecules from a feedstock or slurry to produce biotherapeutics. This purification technique can be used in a variety of applications from gene therapies to biosimilars and bio-betters to vaccines and more. It is a cost effective and efficient purification solution that enables high purity and high yield of the target molecule under optimal conditions.

When you need high performance and high throughput on a large scale, POROS bulk chromatography resins are the industry standard for process-scale bioseparations. Utilized in multiple processes, these breakthrough resins combine optimal particle size and pore structure with a rigid backbone and proprietary chemistries. POROS 50 µm resins demonstrate exceptionally high resolution, dynamic binding capacity, and capture efficiency over a range of flow rates and are primarily used in polish applications.

CaptureSelect affinity resins offer superior selectivity resulting in higher yields and improved purity in the initial capture step. We have developed numerous products for large-scale purification of various biologics such as antibodies and antibody fragments, fusion proteins, hormones, and viruses.

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POROS chromatography resins ›

Ion exchange resins
Artistic rendition of HPLC trace
Affinity resins
Photo of affinity chromatography set up
Custom resins
Scientist working in large scale chromatography setting
Hydrophobic interaction chromatography
Product photo for HIC resins

Bioprocessing chromatography products and services

CaptureSelect affinity ligands, based on Camelid-derived single domain antibody fragments, are available for use in large-scale manufacturing processes. Paired leakage assays offer additional tools for process development or for routine quality control processes.

  • POROS MabCapture A Select Resin
    POROS™ MabCapture™ A Select is a new high-throughput, lower-priced Protein A chromatography resin, combining past improvements to MabCapture A with our own Protein A ligand, enabling the same high-throughput purification performance at a significant reduction in price over most Protein A chromatography resins
  • POROS Heparin 50 µm Bulk Resin
    Heparin affinity media for process-scale separation of biomolecules with specific Heparin binding affinity, such as growth factors and other serum components, including coagulation factors and nucleotide binding proteins.
  • POROS XQ 50 µm Bulk Resin
    A next-generation strong anion exchange resin that delivers a combination of high capacity, high resolution, and high salt tolerance for greater process flexibility and performance.

  • POROS XS 50 µm Bulk Resin
    A next-generation strong cation exchange resin that delivers a combination of high capacity, high resolution, and high salt tolerance for greater process flexibility and performance.

  • POROS HS 50 µm Bulk Resin
    A strong cation exchange resin offering high resolution for the removal of process contaminants and product impurities in downstream polish applications

  • POROS HQ 50 µm Bulk Resin
    A strong anion exchange resin providing high resolution with high protein binding capacity and efficiency

  • POROS D 50 µm Bulk Resin
    A weak anion exchange resin providing a high through-put alternative to traditional DEAE resins

Save time and money by purifying your proteins using our pre-packed chromatography columns. We offer a wide range of columns pre-packed with a selection of our bioprocess chromatography resins, including affinity/capture, ion exchange or hydrophobic interaction chromatography (HIC). RoboColumn products can be used for high throughput screening during process development. GoPure columns are also used for bench scale bioseparations during process development and preparative chromatography. MiniChrom columns are process development scale suitable for bench top purification and preparative chromatography. The aforementioned resin types are available in a variety of prepacked column formats.

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CaptureSelect affinity ligands, based on Camelid-derived single domain antibody fragments, are available for use in large-scale manufacturing processes. Paired leakage assays offer additional tools for process development or for routine quality control processes.

  • POROS MabCapture A Select Resin
    POROS™ MabCapture™ A Select is a new high-throughput, lower-priced Protein A chromatography resin, combining past improvements to MabCapture A with our own Protein A ligand, enabling the same high-throughput purification performance at a significant reduction in price over most Protein A chromatography resins
  • POROS Heparin 50 µm Bulk Resin
    Heparin affinity media for process-scale separation of biomolecules with specific Heparin binding affinity, such as growth factors and other serum components, including coagulation factors and nucleotide binding proteins.
  • POROS XQ 50 µm Bulk Resin
    A next-generation strong anion exchange resin that delivers a combination of high capacity, high resolution, and high salt tolerance for greater process flexibility and performance.

  • POROS XS 50 µm Bulk Resin
    A next-generation strong cation exchange resin that delivers a combination of high capacity, high resolution, and high salt tolerance for greater process flexibility and performance.

  • POROS HS 50 µm Bulk Resin
    A strong cation exchange resin offering high resolution for the removal of process contaminants and product impurities in downstream polish applications

  • POROS HQ 50 µm Bulk Resin
    A strong anion exchange resin providing high resolution with high protein binding capacity and efficiency

  • POROS D 50 µm Bulk Resin
    A weak anion exchange resin providing a high through-put alternative to traditional DEAE resins

Save time and money by purifying your proteins using our pre-packed chromatography columns. We offer a wide range of columns pre-packed with a selection of our bioprocess chromatography resins, including affinity/capture, ion exchange or hydrophobic interaction chromatography (HIC). RoboColumn products can be used for high throughput screening during process development. GoPure columns are also used for bench scale bioseparations during process development and preparative chromatography. MiniChrom columns are process development scale suitable for bench top purification and preparative chromatography. The aforementioned resin types are available in a variety of prepacked column formats.

Shop prepacked columns ›

Packing rigid POROS chromatography resins:
efficient and fast method to get optimal results.

Watch how to pack POROS chromatography resins.

Bioprocessing resources

Access a targeted collection of scientific application notes, case studies, posters, white papers and more for bioprocessing: