Graphic of a bioreactor and a chromatogram

What is process scale chromatography?

Process scale chromatography is a scalable cGMP manufacturing technique for the separation of biomolecules from a feedstock or slurry to produce biotherapeutics. This purification technique can be used in a variety of applications from gene therapies to biosimilars and bio-betters to vaccines and more. It is a cost effective and efficient purification solution that enables high purity and high yield of the target molecule under optimal conditions.

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When you need high performance and high throughput on a large scale, POROS bulk chromatography resins enable outstanding performance for process-scale bioseparations. Utilized in multiple processes, these breakthrough resins combine optimal particle size and pore structure with a rigid backbone and proprietary chemistries. POROS 50 µm resins demonstrate exceptionally high resolution, dynamic binding capacity, and capture efficiency over a range of flow rates and are primarily used in polish applications.

CaptureSelect affinity resins offer excellent selectivity resulting in higher yields and improved purity in the initial capture step. We have developed numerous products for large-scale purification of various biologics such as antibodies and antibody fragments, fusion proteins, hormones, and viruses.

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Affinity resins

Chromatography affinity resins for downstream purification

Non-affinity resins

Ion exchange chromatography resin and hydrophobic interaction chromatography resin

Custom resins

Custom chromatography services for unique molecules

Packing rigid POROS chromatography resins:
efficient and fast method to get optimal results.

Watch how to pack POROS chromatography resins.

Bioprocessing resources

Access a targeted collection of scientific application notes, case studies, posters, white papers and more for bioprocessing:

Pharmaceutical Grade Reagent. For Manufacturing and Laboratory Use Only.