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We have developed an innovative portfolio of affinity chromatography resins to help you solve challenges in the downstream process of next-generation antibody therapeutics. These resins are specifically designed for the purification of engineered monoclonal antibody (mAbs) modalities. |
CaptureSelect affinity chromatography resins, specifically developed to bind antibody-subdomain regions are a key solution for the purification of novel antibody therapeutics, such as bi-specific monoclonal antibodies, Fab fragments, and Fc-fusion proteins. These resins are based on the CaptureSelect technology, enabling increased purity and yield in a single purification step.
Due to the unique selectivity of each resin, a broad range of antibody modalities can be captured. The antibody-subdomain-specific resins help to improve downstream processing of monoclonal antibodies and antibody fragments, and serve as an alternative solution when Protein A does not yield optimal results.
CaptureSelect affinity resins are scalable platform purification solutions, non-animal derived, and suitable for cGMP manufacturing.
Benefit from:
In addition to our subdomain-specific IgG resins, we offer a highly specific resin for when you are working on IgE drug development. The CaptureSelect IgE affinity matrix helps provide efficient purification of IgE from plasma and recombinant sources.
This article describes the performance of CaptureSelect antibody affinity resins, including rapid implementation into a commercial manufacturing process of a next-generation antibody therapeutic.
All CaptureSelect antibody purification resins are available as loose resin in different unit sizes. For your process development needs, the resins are available in pre-packed columns in high-throughput screening format and for bench-scale screening purposes. Additionally, when your unique purification needs cannot be met with off-the-shelf resins, our custom chromatography resin service can help with solving your specific challenge. Click on the product table below to see all available resins.
Resin | Purifies | Characteristics | Unit size | Catalog number |
CaptureSelect CH1-XL |
|
| 5 mL | |
10 mL | ||||
50 mL | ||||
250 mL | ||||
1 L | ||||
5 L | ||||
CaptureSelect KappaXP |
|
| 5 mL | |
10 mL | ||||
50 mL | ||||
250 mL | ||||
1 L | ||||
5 L | ||||
CaptureSelect LambdaXP |
|
| 5 mL | |
10 mL | ||||
50 mL | ||||
250 mL | ||||
1 L | ||||
5 L | ||||
CaptureSelect FcXP Affinity Matrix |
|
| 5 mL | |
10 mL | ||||
50 mL | ||||
250 mL | ||||
1 L | ||||
5 L | 194371205L | |||
POROS CaptureSelect FcXP Affinity Resin |
|
| 50 mL | |
250 mL | ||||
1000 mL | ||||
5000 mL | ||||
10000 mL | A56254 |
Products incorporating CaptureSelect technology are used for clinical and commercial manufacturing of a variety of biologics. To complement each affinity resin, we offer product specific ELISAs to measure ligand potentially leaching from the column. Click on the product table below to see all available ELISAs.
Product | Catalog number | Unit size | Complementing resin |
CaptureSelect CH1-XL Ligand Leakage ELISA | 1 assay | CaptureSelect CH1-XL | |
10 assays | |||
CaptureSelect KappaXP Ligand Leakage ELISA | 1 assay | CaptureSelect KappaXP | |
10 assays | |||
1 assay | CaptureSelect LambdaXP | ||
10 assays | |||
CaptureSelect FcXP Ligand Leakage ELISA | 1 assay | CaptureSelect FcXP | |
10 assays | |||
CaptureSelect IgG-CH1 Ligand Leakage ELISA | 1 assay | ||
10 assays | |||
50 assays | |||
CaptureSelect KappaXL Ligand Leakage ELISA | 1 assay | ||
10 assays | |||
50 assays | |||
CaptureSelect FcXL Ligand Leakage ELISA | 1 assay | ||
10 assays | |||
CaptureSelect KappaSelect Leakage ELISA | 1 assay | KappaSelect affinity resin* | |
10 assays | |||
CaptureSelect LambdaFabSelect Leakage ELISA | 1 assay | LambdaFabSelect affinity resin* | |
10 assays | |||
CaptureSelect IgSelect Leakage ELISA | 1 assay | IgSelect affinity resin* |
*Products sold through Cytiva Life Sciences
Use this interactive decision-making tool to determine the right chromatography resin for your purification process.
Check out the new Chromatography Learning Lab from Thermo Fisher Scientific, providing a robust range of webinars, articles, eBooks, infographics, and other digital resources to help you optimize the use of our purification products in your process.
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