Large Scale POROS bulk chromatography resins
When you need high performance and high throughput on a large scale, POROS™ bulk chromatography resins are the industry standard for process-scale bioseparations.

Utilized in multiple processes, these breakthrough resins combine optimal particle size and pore structure with a rigid backbone and proprietary chemistries. POROS™ 50 µm resins demonstrate exceptionally high resolution, dynamic binding capacity, and capture efficiency over a range of flow rates and are primarily used in polish applications.

CaptureSelect™ affinity resins offer superior selectivity resulting in higher yields and improved purity in the initial capture step. We have developed numerous products for large-scale purification of various biologics such as antibodies and antibody fragments, fusion proteins, hormones, and viruses.

Custom resins
State-of-the-art manufacturing capability

POROS™ resins are manufactured from approved raw materials to finished product using advanced, proprietary processes that make us unique in this industry. A 30,000 square foot, state-of-the-art chemical facility, in Bedford, Massachusetts, is dedicated to the production of all the POROS™ chromatography resins. Quality testing is performed at all stages to ensure excellent lot-to-lot consistency. POROS chromatography resins are manufactured under ISO 9001:2008 and ISO 13485:2003 standards.

  • CaptureSelect™ Bioprocess Products
    CaptureSelect™ affinity ligands, based on Camelid-derived single domain antibody fragments, are available for use in large-scale manufacturing processes. Paired leakage assays offer additional tools for process development or for routine quality control processes.
  • POROS™ MabCapture™ A Select Resin
    POROS™ MabCapture™ A Select is a new high-throughput, lower-priced Protein A chromatography resin, combining past improvements to MabCapture A with our own Protein A ligand, enabling the same high-throughput purification performance at a significant reduction in price over most Protein A chromatography resins
  • POROS™ MabCapture™ A Resin
    A high performance Protein A chromatography resin technology combining improvements made in bead and chemistry technology to provide high dynamic binding capacities and excellent capture efficiencies at high linear velocities
  • POROS™ Heparin 50 µm Bulk Resin
    Heparin affinity media for process-scale separation of biomolecules with specific Heparin binding affinity, such as growth factors and other serum components, including coagulation factors and nucleotide binding proteins.
  • POROS™ XQ 50 µm Bulk Resin
    A next-generation strong anion exchange resin that delivers a combination of high capacity, high resolution, and high salt tolerance for greater process flexibility and performance.

  • POROS™ XS 50 µm Bulk Resin
    A next-generation strong cation exchange resin that delivers a combination of high capacity, high resolution, and high salt tolerance for greater process flexibility and performance.

  • POROS™ HS 50 µm Bulk Resin
    A strong cation exchange resin offering high resolution for the removal of process contaminants and product impurities in downstream polish applications

  • POROS™ HQ 50 µm Bulk Resin
    A strong anion exchange resin providing high resolution with high protein binding capacity and efficiency

  • POROS™ D 50 µm Bulk Resin
    A weak anion exchange resin providing a high through-put alternative to traditional DEAE resins
  • GoPure™ 1.2 cm Diameter Column
    Suitable for media screening or bench-scale purification. It is ideal for scale-down models of process chromatography unit operations (such as viral clearance studies). Column volumes are 5 to 20 mL.

POROS 50 HS Capacity at 5% BreakThrough as a Function of Linear Velocity

Separation of Lysozyme, Chymotrypsinogen and Cytochrome C at Increasing Linear Flow Rates

POROS 50 Micron HQ Cleaning Study