When you need high performance and high throughput on a large scale, POROS® bulk chromatography resins are the industry standard for process-scale bioseparations.

Utilized in multiple processes, these breakthrough resins combine optimal particle size and pore structure with a rigid backbone and proprietary chemistries. POROS® 50 µm resins demonstrate exceptionally high dynamic binding capacity, capture efficiency, and resolution over a range of flow rates.

CaptureSelect™ affinity resins offer superior selectivity resulting in higher yields and improved purity in the initial capture step. We have developed numerous products for large scale purification of various biologics such as antibodies and antibody fragments, fusion proteins, hormones and viruses.


Video: What's in a resin? Find out why the POROS® resin is the best chromatography media available today
View it now >

Webinar: Please join us for our free webinar on a new approach to anion exchange
View it now >

State-of-the-Art Manufacturing Capability

POROS® resins are manufactured from approved raw materials to finished product using advanced, proprietary processes that make us unique in this industry. A 30,000 square foot, state-of-the-art chemical facility, in Bedford, Massachusetts, is dedicated to the production of all the POROS® chromatography resins. Quality testing is performed at all stages to ensure excellent lot-to-lot consistency. POROS® chromatography resins are manufactured under ISO 9001:2008 and ISO 13485:2003 standards. The facility and quality systems are routinely audited by regulated biopharmaceutical companies.

  • CaptureSelect™ Bioprocess Products
    CaptureSelect™ affinity ligands, based on Camelid-derived single domain antibody fragments, are available for use in large-scale manufacturing processes. Paired leakage assays offer additional tools for process development or for routine quality control processes.
  • POROS™ MabCapture™ A Select Resin
    POROS™ MabCapture™ A Select is a new high-throughput, lower-priced Protein A chromatography resin, combining past improvements to MabCapture A with our own Protein A ligand, enabling the same high-throughput purification performance at a significant reduction in price over most Protein A chromatography resins
  • POROS® MabCapture™ A Resin
    A high performance Protein A chromatography resin technology combining improvements made in bead and chemistry technology to provide high dynamic binding capacities and excellent capture efficiencies at high linear velocities
  • POROS® Heparin 50 µm Bulk Resin
    Heparin affinity media for process scale separation of biomolecules with sepcific Heparin binding affinity, such as growth factors and other serum components, including coagulation factors and nucleotide binding proteins.
  • POROS® XQ 50 µm Bulk Resin
    A next-generation strong anion exchange resin that delivers a combination of high capacity, high resolution, and high salt tolerance for greater process flexibility and performance.
  • POROS® XS 50 µm Bulk Resin
    A next-generation strong cation exchange resin that delivers a combination of high capacity, high resolution, and high salt tolerance for greater process flexibility and performance.
  • POROS® HS 50 µm Bulk Resin
    A strong cation exchange resin offering high resolution for the removal of process contaminants and product impurities in downstream polish applications,
  • GoPure™ 1.2 cm Diameter Column
    Suitable for media screening or bench-scale purification. It is ideal for scale-down models of process chromatography unit operations (such as viral clearance studies). Column volumes are 5 to 20 mLs.
Hi performance over broad flow-rate range
POROS 50HS Capacity at 5% BreakThrough as a Function of Linear Velocity
Hi performance over broad flow-rate range
Separation of Lysozyme, Chymotrypsinogen and Cytochrome C at Increasing Linear Flow Rates
Hi performance over broad flow-rate range
POROS 50 Micron HQ Cleaning Study