We have developed a unique portfolio of affinity resins helping you to develop next generation antibody therapeutics. These affinity resins can be used for clinical and commercial production and include:
  • a platform solution for manufacturing of Fab fragments, irrespective of the type of light chain
  • affinity resins offering mild elution conditions for Fc-fusion proteins and pH sensitive IgGs
  • a cost-effective, high performance Protein A resin developed from in-house sourced Protein A

Next to the affinity resins we also offer product specific ELISAs to measure any ligand potentially leaching from the column.

The image below depicts where the various products bind the antibody or antibody fragment.

Antibody Derived Therapeutics

CaptureSelect™ affinity matrices from Thermo Fisher Scientific:

Product

Target applications

Uniqueness

RoboColumn

CaptureSelect™ IgG-CH1

Human IgG antibodies and Fab fragments thereof

CH1 domain binding, no free light chain binding for fragments

 

CaptureSelect™ KappaXL

Human IgG antibodies and Fab fragments thereof containing a kappa light chain

Mild elution for fragments and antibodies

KappaXL

CaptureSelect™ FcXL

Human IgG antibodies and Fc-fusion proteins

CH3 domain binding, human-specific, recognizing all four subclasses, mild elution conditions

FcXL

POROS™
MabCapture™ A Select Resin
Monoclonal antibody capture applications Major increase in process productivity and reduction in downstream bottleneck MabCapture^TM A Select

View additional CaptureSelect™ products ›

Contact a member of our business development team to discuss possibilities for further development of these products.

CaptureSelect™ information


CaptureSelect™ Leakage ELISAs

Products incorporating CaptureSelect™ technology are used for clinical and commercial manufacturing of a variety of biologicals. To support these products Thermo Fisher Scientific has developed product-specific Leakage ELISAs that can be used for routine quality analysis. Below is a list of Leakage ELISAs and their corresponding affinity resins.

Product Complementing resin

CaptureSelect™ IgG-CH1 Ligand Leakage ELISA

CaptureSelect IgG-CH1

CaptureSelect™ KappaXL Ligand Leakage ELISA

CaptureSelect KappaXL

CaptureSelect™ FcXL Ligand Leakage

CaptureSelect FcXL


Resources

Application notes

Articles

  • Application of a novel affinity adsorbent for the capture and purification of recombinant factor VIII compounds. McCue JT, Selvitelli K, Walker J. (2009) J Chromatogr A. 1216(45):7824-30.
  • The first recombinant human coagulation factor VIII of human origin. Casademunt E, Martinelle K, Jernberg M, et al. (2012). Eur J Haematol. 89(2):165-76.

For more information on CaptureSelect