antibody-purification-showcase

We have developed a unique portfolio of affinity resins helping you to develop next generation antibody therapeutics. These resins are based on the CaptureSelect technology, a unique affinity purification solution based on Camelid-derived single domain antibody fragments (VHH).

Antibody Affinity Purification

Our antibody affinity resins can be used for affinity purification of antibodies and antibody fragments, thereby allowing commercial production of antibody therapeutics.

Benefit from:

  • a platform solution for manufacturing of Fab fragments, irrespective of the type of light chain
  • affinity resins offering mild elution conditions for Fc-fusion proteins and pH sensitive IgGs
  • a cost-effective, Protein A resin developed from in-house sourced Protein A

Next to the affinity resins we also offer product specific ELISAs to measure any ligand potentially leaching from the column.

Selectivity of the antibody affinity resins

captureselect-diagram1

Find your desired affinity matrix

Product

Purifies

Characteristics

Robocolumn®^

CaptureSelect CH1-XL

  • Fab fragments
  • Human IgG
  • Human CH1 domain binding
  • Fab purification platform (all Fab κ/λ)
  • No binding of free light chains
  • Efficient elution at milder pH (CH1-XL)

X

CaptureSelect IgG-CH1

 

CaptureSelect KappaXP

  • Human IgG
  • Fab fragments containing a Kappa light chain
  • Human CL – kappa domain binding
  • High Dynamic Binding Capacity
  • Efficient elution at milder pH (Kappa-XP)

X

CaptureSelect KappaXL

X

CaptureSelect FcXL

  • Human IgG
  • Fc-fusion proteins
  • Non protein A binding IgGs
  • Human CH3 domain binding
  • High Dynamic Binding Capacity
  • Efficient elution at milder pH

X

POROS  
MabCapture A Select Resin

  • Human IgG
  • Major increase in process productivity
  • Reduction in downstream bottleneck

X

 

Custom solutions

When your specific process needs cannot be met with current products, our custom chromatography services are available to build you a unique solution.

For more information ›


CaptureSelect Leakage ELISAs

Products incorporating CaptureSelect technology are used for clinical and commercial manufacturing of a variety of biologicals. To support these products Thermo Fisher Scientific has developed product-specific Leakage ELISAs that can be used for routine quality analysis. Below is a list of Leakage ELISAs and their corresponding affinity resins.

Product Complementing resin
CaptureSelect IgG-CH1 Ligand Leakage ELISA CaptureSelect IgG-CH1 Affinity Matrix
CaptureSelect CH1-XL Ligand Leakage ELISA CaptureSelect CH1-XL Affinity Matrix
CaptureSelect KappaXP Ligand Leakage ELISA CaptureSelect Kappa XP Affinity Matrix
CaptureSelect KappaXL Ligand Leakage ELISA CaptureSelect KappaXL Affinity Matrix
CaptureSelect FcXL Ligand Leakage CaptureSelect FcXL Affinity Matrix
CaptureSelect Kappa Select Leakage ELISA Kit KappaSelect *
CaptureSelect Lambda Fab Select Leakage ELISA Kit LambdaFabSelect *
CaptureSelect Ig Select Leakage ELISA Kit IgSelect *

Bioprocessing resources

Click below to access products brochures, training videos, mobile apps, and more.