Production Chemicals and Sourcing Services

Source multi-compendial production chemicals

Our Production Chemicals and Sourcing Services includes a portfolio of market-leading chemical brands for use in cGMP manufacturing, as well as services specific to sourcing, supplier management, and second sourcing assistance.

These services—while not a substitute for specific customer responsibilities in the highly regulated bioprocessing environment—can contribute to significant productivity improvements. Our capabilities drive customer value across risk mitigation, operational efficiencies, and total cost of ownership (TCO).

Production chemical categories

Our access to a global network of suppliers ensures a comprehensive portfolio that covers all chemical categories across the bioprocessing workflow, as well as addressing any unique needs specific to a project or product development. We offer a wide variety of multi-compendial chemicals, both through external manufacturers as well as our internal manufacturing.

Product availability may vary by country and is subject to varying regulatory requirements. Please contact your local sales representative or call 1-919-598-1986 for availability.

Acids and bases are used to adjust the pH of fermentation and cell culture vessels, and they are used to optimize pH conditions for the drug product during harvest, purification, and fill/finish. The pH of drug formulations greatly affects their biopharmaceutical properties.

Product examples
Various grades and concentrations are available.

  • Ammonium solution
  • Boric acid
  • Citric acid, anhydrous
  • Citric acid, monohydrate
  • Glacial acetic acid
  • Hydrochloric acid
  • Nitric acid
  • Phosphoric acid
  • Potassium hydroxide
  • Salicylic acid
  • Sodium bicarbonate
  • Sodium carbonate, anhydrous
  • Sodium carbonate, monohydrate
  • Sodium hydroxide
  • Sodium hydroxide with WFI
  • Sulfuric acid

Manufacturers from our global network

  • Thermo Fisher Scientific
    • Fisher Chemical
  • Avantor
  • Biospectra
  • Greenfield Global
  • Intermountain Life Sciences
  • Irvine Scientific
  • Ricca Chemical
  • Tedia

Amino acids are one of the basic building blocks of life. They are an essential component of upstream cell culture and fermentation. Some amino acids are also used downstream to stabilize finished drug product in the fill/ finish step. 

Product examples
Various grades are available.

  • Glycine
  • L-Alanine
  • L-Arginine
  • L-Arginine monohydrochloride
  • L-Asparagine
  • L-Aspartic acids
  • L-Cysteine hydrochloride, monohydrate
  • L-Glutamic acid
  • L-Glutamine
  • L-Histidine
  • L-Histidine monochloride, monohydrate
  • L-Isoleucine
  • L-Leucine
  • L-Lysine monohydrochloride
  • L-Methionine
  • L-Phenylalanine
  • L-Proline
  • L-Serine
  • L-Threonine
  • L-Tryptophan
  • L-Tyrosine
  • L-Valine
  • N-Acetyl-L-Cysteine
  • N-Acetyl-L-Tyrosine

Manufacturers from our global network

  • Avantor
  • Spectrum Chemical

All living cells must be maintained in a delicate pH balance for optimal functionality. Organisms naturally have mechanisms of regulating pH, but in the biomanufacturing process protein molecules and other cellular components must be stabilized through carefully engineered biochemical methods. Biological buffers are high purity chemicals that are used to stabilize pH in upstream and downstream workflows. 

Product examples
Various grades are available, including low bioburden, low endotoxin, excipient, and API grades.

  • BES
  • BIS TRIS
  • BIS TRIS HCl
  • CAPS
  • CHES
  • Guanidine HCl
  • HEPES
  • HEPES free acid
  • MES
  • MES monohydrate
  • MOPS
  • MOPS free acid
  • PBS
  • Phytochol
  • PIPES
  • TRIS
  • TRIS HCl
  • Tromethamine (Tris Base)

Manufacturers from our global network

  • Avantor
  • ANGUS
  • Biospectra

 

Biomanufacturing processes require the use of high purity biological reagents in order to carry out many of the upstream and downstream engineered processes. For example, biological reagents are used in product harvesting to separate crude product from microbial mass and other solids and liquids to prepare for purification. These reagents are also used in purification, chromatography, and final fill/finish.

Product examples
Various grades are available.

  • DHAA
  • DTE
  • DTT
  • EDAC HCl
  • BCIP 2-NA salt
  • IPTG
  • IPTG, non-animal
  • IPTG, dioxane free
  • Methotrexate
  • PEG
  • PEP-K
  • PEP-TRI
  • PNPP, NA
  • TCEP
  • TCEP HCl
  • Uracil
  • X-Gal
  • X-Gluc
  • XTT

Manufacturers from our global network

  • Avantor
  • BioVectra
 

Every living organism needs energy to survive. Carbohydrates are the main source of energy for all living things, including cultured cells in the biomanufacturing process. They also act as stabilizing components, and many drug formulations specify carbohydrates in the final fill/ finish. 

Product examples
Various grades are available, including low bioburden, low endotoxin, and excipient grades.

  • Dextrose, anhydrous
  • Dextrose, monohydrate
  • D-Galactose
  • Fructose
  • Galactose
  • Hydroxypropyl beta-cyclodextrin
  • Lactose
  • Lactose, monohydrate
  • Maltose
  • Mannitol
  • Raffinose
  • Sorbitol
  • Sucrose (beet or cane derived)
  • Trehalose

Manufacturers from our global network

  • Thermo Fisher Scientific
    • Fisher Chemical
  • Avantor
  • Biospectra
  • Roquette
  • Ingredion
  • Kerry

 

The cleaning of chromatography resins is vital to the safety, quality, and integrity of the final drug product. Our portfolio offers a range of effective cleaning and preservation materials to increase column life and optimize column performance. Columns are expensive components of the biomanufacturing workflow, and can be reused, but only if they are properly preserved and maintained for long term storage.

Product examples
Various grades, concentrations, and blends are available.

  • Acetone
  • Benzyl alcohol
  • Ethanol
  • Ethyl acetate
  • Heptane, N-99
  • Methanol absolute
  • Isopropanol
  • Propylene glycol
  • Sodium hydroxide

Manufacturers from our global network

  • Avantor
  • Greenfield Global
  • Biospectra
  • Intermountain Life Sciences

 

Cleaning and sterility assurance are critical elements of maintaining a cGMP bioproduction environment. We offer high grade cleaning materials in a variety of package configurations in addition to technical support to evaluate and meet your needs.

Product examples
Various grades and concentrations are available.

  • Chematic®
    (full range of products)
  • CIP 100®
  • CIP 150®
  • CIP 220®
  • CIP 300®
  • CIP 310®
  • Decon-Ahol®
  • Ethanol
  • IPA
  • LpH® III st Sterile
  • LpH® III se
  • Methanol
  • One Solution st® LpH® III
  • One Solution st® Vesta-Syde® SQ
  • One Solution st® Vesphene® III
  • ProKlenz® booster
  • ProKlenz® NpH, sterile detergent
  • ProKlenz(R) ONE
  • Septihol®
  • Sodium hydroxide
  • Vesphene® III
  • Vesphene® III st Sterile
  • Vesphene® III se
  • Vesta-Syde® SQ st
  • Vesta-Syde® SQ 64 RTU
  • Vesta-Syde® SQ 128 RTUSpor-Klenz®
  • Spor-Klenz® RTU
  • Ster-Ahol®
  • Vaprox® hydrogen peroxide, sterile

Manufacturers from our global network

  • Avantor
  • Steris
  • Veltek
  • Chemtrade Logistics
  • Decon Labs
  • Dober

Denaturants are important in upstream and downstream bioprocessing. They are used to break down cellular components in harvest and collection so that the drug product can be isolated effectively. Denaturants are used downstream in purification to ensure the proper folding of the desired components of the mixture while inactivating and removing the components that are not desired.

Product examples
Various grades and concentrations are available.

  • 1,4-Dithiothreitol
  • Ammonium sulfate
  • Glycerol (glycerin)
  • Guanidine hydrochloride
  • Guanidine thiocyanate
  • Lithium chloride
  • Sodium dodecyl (SDS)
  • Triton-X
  • Urea

Manufacturers from our global network

  • Avantor
  • ANGUS
  • Biospectra
  • Chattem Chemicals
  • GAC Chemicals
  • Reliable Biopharma

Emulsifiers, also referred to as surfactants, are utilized in bioproduction to prevent surface absorption and to stabilize protein aggregation. These chemicals are important upstream for harvest as well as downstream for fill and finish. Emulsifiers provide long-term stability of the final drug product during storage and transportation.

Product examples
Various grades are available.

  • Polysorbate 80
  • Polysorbate 20

 

Manufacturers from our global network  

  • Avantor
  • Biospectra
  • Spectrum Chemical

Water for Injection (WFI) is used upstream and downstream in the production of process liquids and solutions where endotoxin content must be controlled. It is sterile, non-pyrogenic and must meet all standards for purified water and undergoes additional bacterial endotoxin testing.

Product examples 
Various grades are available.

  • WFI Quality Water
  • WFI
  • Water for irrigation
  • Purified water
  • Molecular grade water
  • Water ultrapure molecular/dell

Manufacturers from our global network

  • Intermountain Life Sciences
  • Greenfield Global
  • Corning Mediatech
  • Irvine Scientific

Used primarily in upstream processes, the selection of high-grade media supplements can greatly impact the performance and yield of cultured cells. These components are critical in ensuring a successful biomanufacturing outcome.

Product examples
Various grades are available.

  • Peptones
  • Soytone
  • TC Yeastolate
  • Tryptic soy broth
  • Yeast extract

Manufacturers from our global network

 

 

Minerals and vitamins are important as cell culture supplements to ensure the optimal nutritional and metabolic profile of cultured cells in upstream workflows. Different cell lines and cell growth conditions require a different mix of minerals and vitamins to optimize performance.

Product examples
Various grades are available.

  • Ascorbic acid
  • Calcium chloride
  • Cupric sulfate
  • D-Biotin
  • Ferric nitrate
  • Ferrous sulfate
  • Folic acid
  • Magnesium chloride
  • Magnesium sulfate
  • Niacin
  • Potassium chloride
  • Potassium phosphate
  • Pyridoxine hydrochloride
  • Riboflavin
  • Sodium acetate
  • Sodium chloride
  • Sodium nitrate
  • Sodium phosphate
  • Thiamine hydrochloride
  • Zinc chloride
  • Zinc sulfate

Manufacturers from our global network

  • Avantor
  • Chemtrade Logistics   
  • DSM Nutritional*
  • Niacet
  • Spectrum Chemical

* This supplier only supplies vitamins, not minerals.

Living organisms are essentially vessels filled with salt dissolved in water. All molecules of life, including biologic drugs, need an optimized salt environment in order to be stable, and to function most effectively. Salts are used in upstream and downstream biologics manufacturing and are functionally important for cell culture optimization and protein stabilization.

Product examples
Various grades are available.

  • Ammonium citrate
  • Ammonium citrate, dibasic
  • Ammonium citrate, tribasic
  • Ammonium sulfate
  • Boric acid
  • Calcium citrate tetrahydrate
  • Calcium chloride, 2- hydrate
  • Calcium hydroxide
  • Calcium lactate, anhydrous
  • Calcium phosphate dibasic, anhydrous
  • Copper citrate hemitrihydrate
  • Copper gluconate
  • Cupric oxide
  • Cupric sulfate, anhydrous
  • Cupric sulfate, monohydrate
  • Cupric sulfate, pentahydrate
  • Ferrous gluconate
  • Ferrous sulfate, heptahydrate
  • Edetate disodium
  • Potassium gluconate, anhydrous
  • Pancreatin
  • Potassium nitrate
  • Potassium phosphate, dibasic
  • Potassium phosphate, monobasic
  • Potassium sulfate
  • Magnesium sulfate, heptahydrate
  • Potassium dihydrogen phosphate
  • Potassium chloride
  • Sodium acetate, anhydrous
  • Sodium acetate, trihydrate
  • Sodium carbonate, anhydrous
  • Sodium chloride
  • Sodium citrate, dihydrate
  • Sodium nitrate
  • Sodium phosphate dibasic, anhydrous
  • Sodium phosphate dibasic, dihydrate
  • Sodium phosphate dibasic, heptahydrate
  • Sodium phosphate, heptahydrate
  • Sodium phosphate, monobasic
  • Sodium phosphate monobasic, monohydrate
  • Sodium sulfate, anhydrous
  • Sodium sulfate decahydrate
  • Sodium nitrate acid
  • Sodium nitrate, XTL
  • Succinic acid
  • Succinic acid, XTL

Manufacturers from our global network

  • Avantor
  • ADM
  • Chemtrade Logistics
  • Spectrum Chemical
  • Tangram

Solvents are widely used for both cleaning of purification columns and for recovery and concentration of drug product. These are used upstream and downstream, as well as for larger scale applications such as cleaning of lines and surfaces in biomanufacturing facilities.

Product examples
Various grades are available.

  • Acetone
  • Acetonitrile
  • Benzyl alcohol
  • Chloroform
  • Dichloromethane
  • Dimethylformamide
  • Dimethylsulfoxide
  • Dioxane
  • Ethanol
  • Ether
  • Ethyl acetate
  • Ethyl ether
  • Ethylene glycol
  • Formaldehyde
  • Heptane
  • Hexane
  • Isopropanol
  • Methanol
  • Methyl ethyl ketone
  • Methanol absolute
  • Methyl alcohol
  • Petroleum ether
  • Pyridine
  • Tetrahydrofuran
  • Toluene
  • Specially denatured alcohol (SDA)

Manufacturers from our global network

  • Thermo Fisher Scientific
    • Fisher Chemical
  • Avantor
  • Greenfield Global
  • Tedia
  • GJ Chemicals
  • Spectrum Chemical

 

Bioprocessing resources

Access a targeted collection of scientific application notes, case studies, posters, white papers and more for bioprocessing:

Service availability may vary by country. Please contact your local sales representative for availability.