Single-Use Bioprocessing

During scale-up of cell culture in the manufacturing of biotherapeutics, specialized approaches are employed to address the unique characteristics of these bioproduction processes. Cell culture conditions and consistent growth are critical to the biochemistry of the active components during expression, recovery, and purification.

Thermo Scientific™ single-use technologies address these specialized needs of biotherapeutic development and manufacturing. Single-use products have revolutionized the field of biomanufacturing: with single-use technologies, it’s now possible to make small amounts of drug product that might be suitable for preclinical and clinical testing. Prior to the availability of these single-use systems, this would have required substantial facilities to produce the material needed.

Single-use technologies are used throughout the workflow of bioproduction, from buffer and media preparation to bioreactor cultures for vaccines to the storage and shipping of intermediates and bulk biologics.

We offer a comprehensive suite of single-use technology products to support all your bioproduction needs, including bioprocess containers and bags, manifold assemblies, outer support containers, single-use fermentorssingle-use bioreactors, and single-use mixers. Our single-use technologies are also designed to integrate perfectly with our portfolio of cell culture serum, media, supplements, buffers, and other process liquids.

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Featured single-use technology products

Single-Use Bioprocess Container Systems

Standard and custom bioprocess container (BPC) bags, tubing sets, and manifolds, covering a range of applications, sizes, and connection systems

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Outer Support Containers

Our systems are designed to meet the high demands of industrial microbiology with efficient mass transfer, mixing, and temperature control.

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Single-Use Bioreactors

Bioreactor platforms designed as stirred-tank reactors for animal cell culture, utilizing single-use product contact surfaces

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Single-Use Mixers

Single-use mixing products for liquid–liquid and powder–liquid mixing of media, buffers, intermediates, and final products

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Advantages of single-use technologies:

  • Reduced contamination risks
  • Lower initial investment costs
  • Lower facility and operating costs
  • Speed, efficiency, and flexibility
Single-use technologies include:
  • Single-use fermentors – These systems are engineered for optimal oxygen mass transfer, mixing, and temperature control and performs comparably to traditional stainless steel systems. Using traditional, fundamental engineering principles, scale-up and process development work are streamlined—offering you cost savings and efficiency.
  • Single-use bioreactors—These bioreactors are designed as stirred-tank reactors for animal cell culture, using traditional stainless steel bioreactor principles to help ensure optimal cell culture performance. They also have the unique advantage of utilizing completely single-use product contact surfaces to reduce contamination and minimize cleanup.
  • Single-use mixers—Our mixers address the needs of proper preparation and mixing of component molecules found in cell culture media, buffers, and other process liquids. These are designed for the liquid–liquid and powder–liquid mixing of media, buffers, intermediates, final products, process liquids, and suspensions—with all the benefits of single-use technology.
  • Single-use bioprocessing container systems—Our bioprocess container (BPC) bags and tubing assemblies are disposable, single-use flexible container systems. They’re commonly used for critical liquid handling applications throughout bioprocessing operations. BPC systems are cost-effective alternatives to conventional stainless steel systems, and are scalable from benchtop to production.
  • Outer support containers—Our outer support containers are designed to hold BPC bags and tank liners for in-process and transportation needs. Support containers are reusable and matched to the chamber dimensions, the weight of the contents, and the functionality required.

Single-use technologies are part of our portfolio of integrated bioprocessing solutions.

Integrated bioprocessing solutions

BioProduction resources

Have questions about Gibco® media, POROS® chromatography resins, Applied Biosystems® SEQ rapid contaminant tests, or our Cell Therapy products?  Click below to access product brochures, training videos, mobile apps, and more.