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Proven bioprocess technology to support your process
The HyPerforma Single-Use Bioreactor (S.U.B.) was designed for high performance, ease-of-use, and high-yield mammalian cell culture and microcarrier process results—all in a flexible solution that can be customized to your workflow and desired end goals.
Key performance of HyPerforma Single-Use Bioreactor
- Ability to readily scale from small to large volumes—use in process development, clinical trials, and large-scale cGMP biomanufacturing
- Plug-and-play setup and operation through standard disposable connectors, facilitating easy integration with most control platforms on the market
- Minimized cleaning or sterilization (apart from traditional monitoring probes); helps reduce the risk of cross-contamination
- Standard hardware and BPC options, including enhanced application specific designs
HyPerforma bioreactor 5:1 turndown ratio vessel
The HyPerforma S.U.B. helps decrease additional bioreactors required for scale-up, as well as reduce footprint and cleanroom space requirements. Important features include:
- Patented crossflow sparger technology for efficient cell culture at lower volumes
- Drilled-hole sparger for effective stripping of CO2 and sufficient O2 delivery to cells
- Lower probe cutouts on vessel for accurate sensing of pH, DO, and temperature
- Bottom jacketed vessel for better heat transfer and temperature control at lower volumes
- Considerable savings in CAPEX and OPEX
Please note that the HyPerforma S.U.B. is also available with a 2:1 turndown ratio.
Bioprocessing containers (BPCs) specific for single-use bioreactor systems
The single-use bioreactor bag—featuring the BioTitan Retention device—is the single-use consumable bag required for use with the bioreactor hardware; it is supplied sterile and ready-to-use and comes complete with the agitator (impeller) assembly, spargers, vent filter, sensor ports and/or sensors, and line sets for media, supplements, and harvest.
The single-use bioreactor bag does not require any facility hook-ups for sterilization or cleaning. A key element of the design is the single-use impeller with bearing/seal assembly that couples directly to the external mixer drive.
The Thermo Scientific Aegis and CX Film portfolio offer a complete bioreactor solution—from process development to commercial production while also helping you reach your sustainability goals in lowering emissions.
HyPerforma Bioreactor automation software and controllers
- Our HyPerforma Bioreactor portfolio can fully integrate with the Delta V-based HyPerforma G3 Bioprocess Controller systems that offer immediate utility.
- Easily scale up and transfer your data. The G3 Bioprocess Controller systems consist of a range of controllers that can be used in research, process development, and full commercial manufacturing.
- Thermo Scientific TruBio software facilitates easy, reliable, and repeatable process development and commercial cell culture processes.
HyPerforma Single-Use Bioreactor literature
Additional resources
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Thermo Fisher Bioprocessing Portfolio
For research use or further manufacturing. Not for diagnostic use or direct administration into humans or animals.