T follicular helper (Tfh) cells are a regulatory class of specialized effector T helper cells that are essential in the development of antigen-specific effector and memory B cell responses. Tfh cells require IL-6, IL-21, and B cell interaction for complete development. A key transcription factor involved in this differentiation is Bcl-6, which regulates the changes in CXCR5 and CCR7 expression required for T cell migration to the follicle. Moreover, unlike the other regulators that induce gene expression, Bcl-6 promotes Tfh cell development by repressing Blimp-1, RORγt, T-bet, and GATA3, as well as several miRNAs.

Relevant recombinant proteins

  • IL-6
    • Essential for inducing Tfh cell differentiation
  • IL-21
    • Essential for inducing Tfh cell differentiation
    • Acts as an autocrine growth factor to maintain Tfh survival