Regulatory T (Treg) cells are specialized CD4+ T cells that function to maintain self-tolerance and immune homeostasis by suppressing the activation, proliferation, and effector functions of various immune cells.

Relevant recombinant proteins

  • IL-2
    • Support the development of Treg in the thymus and maintain peripheral homeostasis by signaling through CD122 (IL-2Rβ)
  • TGF-beta
    • Induces Foxp3 expression. Necessary for conversion of Th0 cells to Treg in the presence of antigen stimulation of the appropriate level