Physiological T Cell Activation
Dynabeads® T cell activation and expansion products mimic in vivo T cell activation.
Dynabeads™ mimic in vivo T cell activation from antigen-presenting cells (APCs) and provide simultaneous signals to TCR/CD3 and CD28.
No need for autologous APC, mitogens, antigen or feeder cells.
Physiological activation of mouse/human T cells using Dynabeads is highly consistent.You can even use the same technology platform when moving from mouse or human studies to clinical research.
* Larger volume-sizes (2 ml and 10 ml) are also available. Note that these larger volumes are sold under the name Dynabeads® CD3/CD28 T Cell Expander (Cat. no. 11-31D and 111-32D) and Dynabeads® Mouse CD3/CD28 T Cell Expander (Cat. no. 114-52D and 114-53D).
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- Hami, L. et al. (2003) Comparison of a static process and a bioreactor-based process for the GMP manufacture of autologous Xcellerated T cells for clinical trials. BioProcessing Journal Vol. 2 No. 6, November/December 2003.
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- Godfrey, W.R. et al. (2004) In vitro expanded human CD4+CD25+ T regulatory cells can markedly inhibit allogeneic dendritic cell stimulated MLR cultures. Blood 104:453–461.
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- Levine, BL. et. al. (2002) Adoptive transfer of costimulated CD4+ T cells induces expansion of peripheral T cells and decreased CCR5 expression in HIV infection. Nat Med 8:47-53.
- Earle, KE. et. al. (2005) In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation. Clin Immunol 115(1):3-9.