High-Content Screening (HCS)

High Content Screening (HCS)-High Content Analysis (HCA) platforms are designed for exceptional resolution with subcellular, automated detection, and phenotyping with intact, fixed, or live cells.

Our high-content screening portfolio consists of Thermo Scientific CellInsight CX5, CX7 LED, and CX7 LZR HCS platforms and HCS Studio software are made to provide you cutting-edge images and high content imaging data in no time.

HCS/HCA was invented by and registered as a trademark of Cellomics, which is now part of Thermo Fisher Scientific.

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  • Using a combination of established technologies, the CellInsight HCS Platforms can help address both cellular-level intensity and morphological measurements.
  • HCS platforms, powered by our proprietary HCS Studio quantitative analysis software saves time by performing simultaneous imaging with cell-level quantification and advanced statistics.
  • This real-time analysis approach helps to assure immediate data availability post-scan and aids researchers in making informed decisions more quickly.
  • Our HCS technology is one of the industry leaders, as supported by more than 2,000 peer-reviewed publications on over 30 validated assays.

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Fluorescence imaging results of A549 spheroids following 3D culture clearing

Visual and quantitative analysis of 3D cell models

Explore how Thermo Fisher’s Imaging and Analysis Platforms help ensure clear and rapid visualization of any 3D Model System.

Learn how to monitor and analyze 3D cell models

Automated Imaging and Analysis Platforms

CellInsight CX5 Automated Imaging and Analysis Platform

CellInsight CX5

Compact widefield screening system to scale up your throughput

  • Ideal for researchers needing optics that deliver optimal assay sensitivity
  • Provides the robust data and throughput demanded
  • Allows for cell-level analysis as imaging occurs
  • Powerful image processing algorithms
  • High-speed image acquisition

Once you purchase instrument then, register your HCS instrument here.

CellInsight CX7 Automated Imaging and Analysis Platform

CellInsight CX7

Integrated performance modes designed for flexibility and discovery

  • Ideal for multiplex biology, including time-lapse and live-cell imaging
  • Provides multiple outputs that would take several assays to obtain on traditional systems
  • Solid state high-intensity 7-color LED light engine
  • Flexibility of widefield or confocal imaging in all 7 wave-lengths
  • High-resolution fluorescence microscopy images
  • EurekaScan enabled
High-content screening instrument

CellInsight CX7 LZR

Designed with 3D cell models in mind

  • Ideal for 3D organoid and spheroid imaging
  • 7-distinct, solid-state lasers to facilitate both widefield and confocal screens
  • Designed to provide sensitivity and speed needed for emerging 3D assays
  • Delivers better light penetration to sample and superior image quality
  • Widefield and confocal imaging can be combined in the same run
  • EurekaScan enabled

Add capabilities when you need or when budget allows

Invitrogen HCA Onstage Incubator

Invitrogen HCA Onstage Incubator

Enable live-cell imaging and real-time quantitative analysis with our environmental control chamber. When combined with the Invitrogen High-Content Analysis (HCA) Onstage Incubation system, the CellInsight Platform is ideal for time-lapse imaging at high resolution and for 3D acquisition. The environmental chamber mimics both physiological and non-physiological conditions, making the system ideal for demanding hypoxia experiments in 3D cell models. These capabilities are complimented by HCS Studio Cell Analysis Software for increased statistical power.

Orbitor RS Microplate Mover

Orbitor RS Microplate Mover

The CellInsight HCS Platforms can be equipped for automated high-throughput screening using the Orbitor RS plate handler. You can increase the processing capacity up to 80 plates with our automation solution. The HCS Studio software can directly operate the Orbitor instrument, eliminating the need for third-party software.

Which HCS system is right for you?

  CellInsight CX5 Platform CellInsight CX7 Platform CellInsight CX7 LZR Platform
Illumination 5 channels 7 channels 7 channels
Widefield 5 channels 6 color high output LED 7 color laser excitation
Brightfield White 4 specific LED + white light for higher contrast imaging 4 specific LED + white light for higher contrast imaging
Confocal NA Spinning disk 40 µm/70 µm Spinning disk 40 µm/70 µm
Onboard real-time analysis software HCS Studio 4.0 Cell Analysis Software HCS Studio 4.0 Cell Analysis Software HCS Studio 4.0 Cell Analysis Software
Objectives 2x-60x 2x-60x 2x-60x
Focus Software Laser and software Laser and software
Z-stack acquisition yes yes yes
Microplate types 6 to 1,536 wells 6 to 1,536 wells 6 to 1,536 wells
Microscope slides yes yes yes
Live-cell and time-lapse imaging Optional on-stage incubator with kinetic scheduling of acquisition and analysis
Database STORE Express Image and Database Management Software Included, Scalable SQL/Oracle database options available