High Content Analysis Instruments Citations

HCA cited in peer-reviewed journals

Thermo Scientific high-content analysis instruments are cited extensively in reputable publications. HCA instrument citations in peer-reviewed publications are displayed here. HCA comprises a powerful combination of fluorescence microscopy, image processing, automated cellular measurements, and informatics tools that has enabled fundamental discoveries in basic research—and progression in drug compound discovery. See how researchers like you are using Thermo Scientific CellInsight High-Content Screening (HCS) Platforms to publish their results. Choose a section from one of the tabs below.

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Application Title Source Year
cancer, neuroscience, stem cells, virology Commentary on, “Generation of Three-dimensional Human Neuronal Cultures: Application to Modeling CNS Viral Infections” Journal of Infectiology 2019
cancer, neuroscience Competitive inhibition by NAG-1/GDF-15 NLS peptide enhances its anti-cancer activity Biochem Biophys Res Commun 2019
cancer, immunotherapy Development of in vitro immune effector function assays to better approximate the in vivo behavior of biotherapeutics and cell therapies Journal for ImmunoTherapy of Cancer 2019
cancer, neuroscience, stem cells Effects of hypoxia and ASIC3 on nucleus pulposus cells: from cell behavior to molecular mechanism Biomedicine & Pharmcotherapy 2019
cancer, neuroscience, stem cells, organoids Review of high-content screening applications in toxicology Archives of Toxicology 2019
cancer, neuroscience, stem cells, organoids Shedding light on microRNA function via microscopy-based screening Methods 2019
stem cells thalidomide inhibits Human ipSc Mesendoderm Differentiation by Modulating cRBn-dependent Degradation of SALL4 Scientific Reports 2020

No records were found matching your criteria

Application Title Source Year
cancer, neuroscience A combined cellomics and proteomics approach to uncover neuronal pathways to psychiatric disorder Neuroproteomics 2019
cancer A lung/liver-on-a-chip platform for acute and chronic toxicity studies Lab on a Chip 2018
cancer, immunotherapy, neuroscience, stem cells A Novel Three-Dimensional Glioma Blood-Brain Barrier Model for High-Throughput Testing of Tumoricidal Capability Frontiers in Oncology 2019
cancer, immunotherapy A novel three-dimensional immune oncology model for high-throughput testing of tumoricidal activity Frontiers in Immunology 2018
cancer A simple pyramid-shaped microchamber towards highly efficient isolation of circulating tumor cells from breast cancer patients Biomed Microdevices 2018
neuroscience Analysis of novel endosome-to-Golgi retrieval genes reveals a role for PLD3 in regulating endosomal protein sorting and amyloid precursor protein … Cellular and Molecular Life … 2018
cancer, neuroscience, stem cells AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A Nature Communication 2018
neuroscience, stem cells, virology Atovaquone inhibits arbovirus replication through the depletion of intracellular nucleotides Journal of Virology 2019
neuroscience, stem cells Beyond 2D: effects of photobiomodulation in 3D tissue-like systems Journal of Biomed Opt. 2020
cancer, immunotherapy Boosting Natural Killer Cell-Mediated Targeting of Sarcoma Through DNAM-1 and NKG2D Frontiers in Immunology 2020
cancer, immunotherapy, neuroscience, stem cells, virology Cancer exosomes induce tumor innervation Nature Communication 2018
stem cells Chaperone mediated detection of small molecule target binding in cells Nature Communication 2020
cancer DDIT4 promotes gastric cancer proliferation and tumorigenesis through the p53 and MAPK pathways Cancer Communication 2018
cancer Development of a FRET-Based Assay for Analysis of mAbs Internalization and Processing by Dendritic Cells in Preclinical Immunogenicity Risk Assessment The AAPS Journal 2020
cancer, neuroscience Dopamine increases HIV entry into macrophages by increasing calcium release via an alternative signaling pathway Brain, Behavior, and Immunology 2019
virology Evolution-driven attenuation of alphaviruses highlights key glycoprotein determinants regulating viral infectivity and dissemination Cell Reports 2019
stem cells Extension of maximal lifespan and high bone marrow chimerism after nonmyeloablative syngeneic transplantation of bone marrow from young to old Mice Frontiers in Genetics 2019
  General staining and segmentation procedures for high content imaging and analysis Methods Mol Biol 2018
cancer, neuroscience, stem cells, organoids Generation of three-dimensional human neuronal cultures: application to modeling CNS viral infections Stem Cell Research  2018
cancer, neuroscience Granulovacuolar degeneration bodies are neuron-selective lysosomal structures induced by intracellular tau pathology Acta Neuropathol 2019
cancer, neuroscience High content screening for drug discovery from traditional Chinese medicine Chinese medicine 2019
cancer, neuroscience High levels of PIWI‐interacting RNAs are present in the small RNA landscape of prostate epithelium from vitamin D clinical trial specimens The Prostate 2019
cancer, virology High-Content Screening, a Reliable System for Coxiella burnetii Isolation from Clinical Samples Journal of Clinical Microbiol 2020
cancer, neuroscience High-Throughput Fluorescence Assays for Ion Channels and GPCRs Adv Exp Med Biol 2020
virology High-throughput isolation of giant viruses using high-content screening Communications Biology 2019
  In Vitro High-Content Imaging-Based Phenotypic Analysis of Bronchial 3D Organotypic Air–Liquid Interface Cultures SLAS 2020
cancer, neuroscience, stem cells In vitro screening platforms for identifying autophagy modulators in mammalian cells Autophagy 2019
neuroscience Inhibition of TBC1D5 activates Rab7a and can enhance the function of the retromer cargo-selective complex J Cell Sci 2018
cancer, neuroscience Isoscoparins R and S, two new ent-clerodane diterpenoids from Isodon scoparius Journal Asian Nat Prod Res 2019
cancer, neuroscience MARCKS regulates neuritogenesis and interacts with a CDC42 signaling network Scientific reports 2018
neuroscience, stem cells, organoids Modeling Leigh syndrome using patient-specific induced pluripotent stem cells Osaka City Med J 2019
  Modular, defined assembly of antibody-based constructs using click chemistry Keystone Symposia 2018
neuroscience Modulation of CRMP2 via (S)-Lacosamide shows therapeutic promise but is ultimately ineffective in a mouse model of CLN6-Batten disease Health Psychol Behav Med 2019
cancer, neuroscience New insights into mechanism of bisphenol analogue neurotoxicity: implications of inhibition of O-GlcNAcase activity in PC12 cells Archives of Toxicology 2019
cancer, neuroscience No evidence for cell‐to‐cell transmission of the unfolded protein response in cell culture Journal of Neurochem 2019
cancer Non-Toxic and Ultra-Small Biosilver Nanoclusters Trigger Apoptotic Cell Death in Fluconazole-Resistant Candida albicans via Ras Signaling Biomolecules 2019
cancer, neuroscience OPTN recruitment to a Golgi-proximal compartment regulates immune signalling and cytokine secretion Journal of Cell Science 2020
neuroscience, stem cells Partial FMRP expression is sufficient to normalize neuronal hyperactivity in Fragile X neurons European Journal of Neuroscience 2019
cancer, neuroscience Phosphorylation of syntaxin 17 by TBK1 controls autophagy initiation Developmental Cell 2019
cancer, neuroscience, stem cells Population-based analysis of BAP1 germline variations in patients with uveal melanoma Human Molecular Genetics 2019
cancer, immunotherapy, stem cells, organoids Replication Study: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment eLife 2019
cancer, neuroscience, stem cells, organoids Review of high-content screening applications in toxicology Archives of Toxicology 2019
neuroscience Role of the AP-5 adaptor protein complex in late endosome-to-Golgi retrieval PLoS Biol 2018
cancer, neuroscience, stem cells, organoids Shedding light on microRNA function via microscopy-based screening Methods 2019
  Super-multiplexed fluorescence microscopy via photostability contrast Biomedical optics  2018
stem cells thalidomide inhibits Human ipSc Mesendoderm Differentiation by Modulating cRBn-dependent Degradation of SALL4 Scientific Reports 2020
cancer, virology The ETS transcription factor ELF1 regulates a broadly antiviral program distinct from the type I interferon response PLoS Pathog 2019
  The WDR11 complex facilitates the tethering of AP-1-derived vesicles Nature Communication 2018
cancer Tools to measure autophagy using high content imaging and analysis Methods Mol Biol 2018
cancer, neuroscience Unconventional secretion factor GRASP55 is increased by pharmacological unfolded protein response inducers in neurons Scientific Reports 2019
cancer Vitamin D regulates prostate cell metabolism via genomic and non-genomic mitochondrial redox-dependent mechanisms The Journal of Steroid Biochemistry and Molecular … 2019
cancer, immunotherapy Wedge-shaped microfluidic chip for circulating tumor cells isolation and its clinical significance in gastric cancer Journal Transl Med 2018

No records were found matching your criteria

Application Title Source Year
virology A Hyperstabilizing Mutation in the Base of the Ebola Virus Glycoprotein Acts at Multiple Steps To Abrogate Viral Entry Molecular Biology of the Cell 2018
neuroscience A novel inhibitor of inducible NOS dimerization protects against cytokine‐induced rat beta cell dysfunction Br J Pharmacol 2018
virology A novel piperazine-based drug lead for cryptosporidiosis from the medicines for malaria venture open-access malaria box Antimicrob Agents Chemother 2018
cancer, neuroscience Activated heterotrimeric G protein αi subunits inhibit Rap-dependent cell adhesion and promote cell migration J Biol Chem 2018
cancer, immunotherapy ADME/toxicity prediction and antitumor activity of novel nitrogenous heterocyclic compounds designed by computer targeting of alkylglycerone phosphate … Oncol Lett 2020
stem cells Advances in antiwolbachial drug discovery for treatment of parasitic filarial worm infections Trop Med Infect Dis 2020
cancer, neuroscience Analysis of Gene Expression and Neuronal Phenotype in Neuroscreen-1 (NS-1) Cells Int J Biomed Investig 2019
cancer Bifunctional Au-templated RNA nanoparticles enable direct cell uptake detection and GRP75 knockdown in prostate cancer J Mater Chem B 2018
neuroscience, stem cells, virology C9orf72-generated poly-GR and poly-PR do not directly interfere with nucleocytoplasmic transport Sci Rep 2019
immunotherapy, virology Convergent Structures Illuminate Features for Germline Antibody Binding and Pan-Lassa Virus Neutralization Cell 2018
immunotherapy, virology Design and evaluation of bi-and trispecific antibodies targeting multiple filovirus glycoproteins J Biol Chem 2019
neuroscience, stem cells Differential effects of glucose deprivation on the survival of fetal versus adult neural stem cells‐derived oligodendrocyte precursor cells Glia 2018
  DMN-Tre Labeling for Detection and High-Content Screening of Compounds against Intracellular Mycobacteria ACS Omega 2018
cancer Downregulation of MicroRNA-4463 Attenuates High-Glucose-and Hypoxia-Induced Endothelial Cell Injury by Targeting PNUTS Cell Physiol Biochem 2019
cancer, organoids eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma Nature Communication 2018
cancer Enhanced cancer theranostics with self-assembled, multilabeled siRNAs ACS Omega 2019
virology Floxed-cassette allelic exchange mutagenesis enables markerless gene deletion in Chlamydia trachomatis and can reverse cassette-induced polar effects J Bacteriol 2020
cancer, virology Fluorescently Labeled siRNAs and their Theranostic Applications in Cancer Gene Therapy ACS Omega 2018
neuroscience, stem cells, virology FUS-induced neurotoxicity in Drosophila is prevented by downregulating nucleocytoplasmic transport proteins Hum Mol Genet 2018
cancer, stem cells Genome-Wide Association Study of Diabetogenic Adipose Morphology in the GENetics of Adipocyte Lipolysis (GENiAL) Cohort Cells 2020
cancer, stem cells Glucocorticoids delay RAF-induced senescence promoted by EGR1 J Cell Sci 2018
cancer, stem cells Glutamine Links Obesity to Inflammation in Human White Adipose Tissue Cell Metabolism 2020
cancer, neuroscience, stem cells GRP78 modulates cell adhesion markers in prostate Cancer and multiple myeloma cell lines BMC Cancer 2020
cancer, stem cells GTPBP4 promotes gastric cancer progression via regulating P53 activity Cell Physiol Biochem 2019
cancer, virology Hemagglutinin Cleavability, Acid Stability, and Temperature Dependence Optimize Influenza B Virus for Replication in Human Airways J Virol 2019
cancer Herbicidins from Streptomyces sp. CB01388 Showing Anti-Cryptosporidium Activity J Nat Prod 2019
cancer, neuroscience High content screening for drug discovery from traditional Chinese medicine Chin Med 2018
  High-Content Screening for Cryptosporidium Drug Discovery Methods Mol Biol 2019
cancer Highly Efficient Isolation of Circulating Tumor Cells Using a Simple Wedge-Shaped Microfluidic Device IEEE Trans Biomed Eng 2019
immunotherapy, virology Human monoclonal antibodies against chikungunya virus target multiple distinct epitopes in the E1 and E2 glycoproteins PLOS Pathog 2019
cancer, stem cells Human-specific function of IL-10 in adipose tissue linked to insulin resistance J Clin Endocrinol Metab 2019
cancer, neuroscience, stem cells In vitro screening platforms for identifying autophagy modulators in mammalian cells Methods Mol Biol 2020
cancer, neuroscience Knockdown siRNA targeting the mitochondrial sodium-calcium exchanger-1 inhibits the protective effects of two cannabinoids against acute paclitaxel toxicity J Mol Neurosci 2020
cancer, neuroscience, stem cells MANF ablation causes prolonged activation of the UPR without neurodegeneration in the mouse midbrain dopamine system eNeuro 2019
cancer MicroRNA-27a/b-3p and PPARG regulate SCAMP3 through a feed-forward loop during adipogenesis Sci Rep 2020
cancer, neuroscience Microscopy-based automated live cell screening for small molecules that affect ciliation Front Genet 2020
cancer, immunotherapy, organoids Modular, defined assembly of antibody-based constructs using click chemistry Keystone Symposia 2019
cancer, neuroscience N-substituted phenylbenzamides of the niclosamide chemotype attenuate obesity related changes in high fat diet fed mice PLOS One 2018
cancer PITPNA-AS1 abrogates the inhibition of miR-876-5p on WNT5A to facilitate hepatocellular carcinoma progression Cell Death Dis 2018
cancer, neuroscience, stem cells Possible Strategies to Optimize a Biomarker Discovery Approach to Correlate with Neurological Outcome in Patients with Spinal Cord Injury: A Pilot Study J Neurotrauma 2018
cancer, neuroscience, stem cells Prolactin, Estradiol and Testosterone Differentially Impact Human Hippocampal Neurogenesis in an In Vitro Model Neuroscience 2018
cancer, neuroscience Protective effect of 3-hydroxybutyrate against endoplasmic reticulum stress-associated vascular endothelial cell damage induced by low glucose exposure PLOS One 2018
cancer Pumpless platform for high-throughput dynamic multicellular culture and chemosensitivity evaluation Lab Chip 2019
 stem cells Recombinant extracellular matrix protein fragments support human embryonic stem cell chondrogenesis Tissue Eng Part A 2019
cancer, stem cells, organoids Shedding light on microRNA function via microscopy-based screening Methods 2018
cancer, immunotherapy, virology Structural Basis of Broad Ebolavirus Neutralization by a Human Survivor Antibody Nat Struct Mol Biol 2019
immunotherapy, stem cells, virology Systematic analysis of monoclonal antibodies against Ebola virus GP defines features that contribute to protection Cell 2019
cancer Techniques to Enable 1536-Well Phenotypic Screening Methods Mol Biol 2019
 stem cells The microbiota regulates inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination PNAS 2019
neuroscience, stem cells The role of nuclear receptors in the differentiation of oligodendrocyte precursor cells derived from fetal and adult neural stem cells Stem Cell Res 2019
 stem cells, virology THP-1 and Dictyostelium infection models for screening and characterization of anti-Mycobacterium abscessus hit compounds Antimicrob Agents Chemother 2019
cancer, virology Vesicular Stomatitis Virus-Based Vaccines Provide Cross-Protection against Andes and Sin Nombre Viruses. Viruses 2019

No records were found matching your criteria

Application Title Source Year
cancer, neuroscience, stem cells, organoids, virology A fluorescent cell-based system for imaging Zika virus infection in real-time Viruses 2018
cancer A genome-wide RNAi screen identifies the SMC5/6 complex as a non-redundant regulator of a Topo2a-dependent G2 arrest Nucleic Acids Res 2019
stem cells A head-to-head Caco-2 assay comparison of the mechanisms of action of the intestinal permeation enhancers: SNAC and sodium caprate (C10) European Journal of Pharm Biopharm 2020
  A high content screening assay for identifying inhibitors against active and dormant state intracellular Mycobacterium tuberculosis Journal of Microbiological Methods 2019
cancer, neuroscience A Multi-Omics Interpretable Machine Learning Model Reveals Modes of Action of Small Molecules Scientific Reports 2020
neuroscience A Novel RNA editing sensor tool and a specific agonist determine neuronal protein expression of RNA-edited glycine receptors and identify a genomic … Frontiers in Molecular Neuro 2018
cancer, stem cells A novel tumor spheroid model identifies selective enhancement of radiation by an inhibitor of oxidative phosphorylation Oncotarget 2019
cancer, neuroscience, stem cells, organoids A SMN2 Splicing Modifier Rescues the Disease Phenotypes in an In Vitro Human Spinal Muscular Atrophy Model Stem Cells and Dev 2019
cancer, neuroscience A stress-enhanced model for discovery of disease-modifying gene: Ece1-suppresses the toxicity of α-synuclein A30P Neurobiology of Disease 2018
cancer, stem cells A β1-tubulin–based megakaryocyte maturation reporter system identifies novel drugs that promote platelet production Blood Adv 2018
cancer, neuroscience Activation of Nrf2 signaling by salvianolic acid C attenuates NF‑κB mediated inflammatory response both in vivo and in vitro Int Immunopharmacol 2018
cancer, virology Advanced identification of global bioactivity hotspots via screening of the metabolic fingerprint of entire ecosystems Scientific Reports 2020
cancer, immunotherapy, stem cells Advanced Materials and Devices for the Regulation and Study of NK Cells International Journal of Molecular Sciences 2019
cancer AMMECR1 Inhibits Apoptosis and Promotes Cell-cycle Progression and Proliferation of the A549 Human Lung Cancer Cell Line Anticancer Res 2019
neuroscience, stem cells An analog derived from phenylpropanoids ameliorates Alzheimer's disease–like pathology and protects mitochondrial function Neurobiology of Aging 2019
cancer, stem cells An endothelial cell/mesenchymal stem cell coculture cord formation assay to model vascular biology in vitro

 

Methods Mol Biol

2018
  Analysis and quantification of oxidized low-density lipoprotein-induced lipid droplets in macrophages through high-content screening: Application for antiatherogenic … Assay and Drug Development Technologies 2019
  Andrographolide protects chondrocytes from oxidative stress injury by activation of the Keap1–Nrf2–Are signaling pathway J Cell Physiol 2019
cancer Anlotinib inhibits synovial sarcoma by targeting GINS1: a novel downstream target oncogene in progression of synovial sarcoma Clinical and Translational Oncology 2019
cancer, immunotherapy, neuroscience Antibody-mediated clearance of tau in primary mouse microglial cultures requires Fcγ-receptor binding and functional lysosomes Scientific Reports 2019
cancer, immunotherapy Anticancer Activity of Earthworm Powder (Lumbricus terrestris) Against MCF-7 and PC-3 Cancer Cell Lines Journal of Gastrointestinal Cancer 2019
  Anti-inflammatory activity of dehydroandrographolide by TLR4/NF-κB signaling pathway inhibition in bile duct-ligated mice Cell Physiol Biochem 2018
cancer, neuroscience Anti-inflammatory effects and mechanism of the total flavonoids from Artemisia scoparia Waldst. et kit. in vitro and in vivo Biomed Pharmacother 2018
cancer, stem cells Arrayed functional genetic screenings in pluripotency reprogramming and differentiation Stem Cell Research & Therapy 2019
stem cells Aryl hydrocarbon receptor modulation by tuberculosis drugs impairs host defense and treatment outcomes Cell Host & Microbe 2020
cancer Assessment of novel tobacco heating product THP1. 0. Part 6: a comparative in vitro study using contemporary screening approaches Regul Toxicol Pharmacol 2018
cancer ATG7 and ATG9A loss-of-function variants trigger autophagy impairment and ovarian failure Genetic Med 2019
cancer Automated Detection of Autophagy Response Using Single Cell-Based Microscopy Assays Autophagy 2019
cancer, neuroscience, stem cells Autophagy contributes to BMP type 2 receptor degradation and development of pulmonary arterial hypertension J Pathology 2019
cancer, immunotherapy, stem cells B591, a novel specific pan-PI3K inhibitor, preferentially targets cancer stem cells Oncogene 2019
cancer BAI1‑associated protein 2‑like 2 is a potential biomarker in lung cancer Oncology Report 2019
cancer, neuroscience, stem cells BCL2 and BCL (X) L selective inhibitors decrease mitochondrial ATP production in breast cancer cells and are synthetically lethal when combined with 2 … Oncotarget 2018
neuroscience Benzalkonium chloride-induced direct and indirect toxicity on corneal epithelial and trigeminal neuronal cells: proinflammatory and apoptotic responses in vitro Toxicology letters 2020
cancer, neuroscience Bioinspired Honokiol Analogs and Their Evaluation for Activity on the Norepinephrine Transporter Molecules 2018
neuroscience Blue light exposure in vitro causes toxicity to trigeminal neurons and glia through increased superoxide and hydrogen peroxide generation Free Radic Biol Med 2019
  Breast Milk and Saliva Lactoferrin Levels and Postnatal Cytomegalovirus Infection Am J Perinatol 2020
cancer, stem cells Cardiac Toxicity From Ethanol Exposure in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Toxicol Sci 2019
cancer, immunotherapy Casein Kinase 2 Interacting Protein-1 Suppresses Glioma Cell Proliferation via Regulating the AKT/GSK3/-Catenin Pathway Biomed Res Int 2019
cancer, stem cells Cell-Based High Content Analysis of Cell Proliferation and Apoptosis High Content Screening 2018
cancer, neuroscience Cell‐based high‐throughput screen for small molecule inhibitors of Bax translocation J Cell Mol Med 2019
cancer Cellular fluorescein hyperfluorescence is dynamin-dependent and increased by Tetronic 1107 treatment Int J Biochem Cell Biol 2018
cancer Chlamydia trachomatis fails to protect its growth niche against pro-apoptotic insults Cell Death Differ 2019
cancer Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion Autophagy 2018
cancer, immunotherapy CIZ1 knockdown suppresses the proliferation of bladder cancer cells by inducing apoptosis Gene 2019
cancer Combined PPARγ activation and XIAP inhibition as a potential therapeutic strategy for ovarian granulosa cell tumors Mol Cancer Therap 2019
cancer, stem cells, virology Compounds producing an effective combinatorial regimen for disruption of HIV‐1 latency EMBO Mol Med 2018
cancer Conjugate Polyplexes with Anti-Invasive Properties and Improved siRNA Delivery In Vivo Bioconjugate Chemistry 2018
cancer, neuroscience, stem cells, organoids Constitutive Activity of a G Protein‐Coupled Receptor, DRD1, Contributes to Human Cerebral Organoid Formation STEM CELLS 2020
cancer, neuroscience CoQ10 ameliorates mitochondrial dysfunction in diabetic nephropathy through mitophagy J Endocrinol  
cancer, neuroscience Cyclin-dependent kinase 18 controls trafficking of aquaporin-2 and its abundance through ubiquitin ligase STUB1, which functions as an AKAP Cells 2020
cancer Cyclodextrin-and dendrimer-conjugated graphene oxide as a nanocarrier for the delivery of selected chemotherapeutic and photosensitizing agents Mater Sci Eng C Mater Biol Appl 2018
cancer, neuroscience, stem cells Cytotoxic Mechanism for Silver Nanoparticles Based High-Content Cellomics and Transcriptome Sequencing J Biomed Nanotechnol 2019
cancer Delivery of miR-146a to Ly6Chigh monocytes inhibits pathogenic bone erosion in inflammatory arthritis Theranostics 2018
cancer, neuroscience, stem cells Detection of Rare Objects by Flow Cytometry: Imaging, Cell Sorting, and Deep Learning Approaches Intl J Mol Science 2020
cancer Development and application of high-content biological screening for modulators of NET production Frontiers in Immunol 2018
  Development and optimization of a miniaturized western blot-based screening platform to identify regulators of post-translational modifications High-throughput 2019
neuroscience Development of a cell-based assay to assess binding of the proNGF prodomain to sortilin Cell Mol Neuro  2018
cancer, immunotherapy, stem cells, virology Development of a novel screening platform for the identification of small molecule inhibitors of human adenovirus Virology 2019
cancer, neuroscience, stem cells Development of Human in vitro Brain-blood Barrier Model from Induced Pluripotent Stem Cell-derived Endothelial Cells to Predict the in vivo Permeability of Drugs Neuroscience Bull 2019
cancer Diazinon exposure activated transcriptional factors CCAAT-enhancer-binding proteins α (C/EBPα) and peroxisome proliferator-activated receptor γ (PPARγ) and … Pesticide Biochemistry and Physiology 2018
  Differentiated mitochondrial function in mouse 3T3 fibroblasts and human epithelial or endothelial cells in response to chemical exposure Basic Clin Pharmacol Toxicol 2019
cancer Differentiation of Aneugens and Clastogens in the In Vitro Micronucleus Test by Kinetochore Scoring Using Automated Image Analysis Environ Mol Mutagen 2019
neuroscience Direct, gabapentin-insensitive interaction of a soluble form of the calcium channel subunit α 2 δ-1 with thrombospondin-4 Scientific Reports 2019
cancer Discovery of the first potent, selective, and orally bioavailable Signal Peptide Peptidase-Like 2a (SPPL2a) inhibitor displaying pronounced immunomodulatory effects … J Med Chem 2018
cancer Discovery of the Polyamine Conjugate with Benzo[cd]indol-2(1H)-one as a Lysosome-Targeted Antimetastatic Agent J Med Chem 2018
cancer, neuroscience Downregulation of CPA4 inhibits non small–cell lung cancer growth by suppressing the AKT/c‐MYC pathway Mol Carcinogen 2019
cancer Downregulation of RNA binding motif protein 17 expression inhibits proliferation of hypopharyngeal carcinoma FaDu cells Oncology 2018
cancer, neuroscience Downregulation of SNRPG induces cell cycle arrest and sensitizes human glioblastoma cells to temozolomide by targeting Myc through a p53-dependent … Cancer Biol Med 2020
cancer, immunotherapy, neuroscience Drug discovery technologies: Caenorhabditis elegans as a model for anthelmintic therapeutics Med Res Rev 2020
virology Dual roles for the ER membrane protein complex in flavivirus infection: viral entry and protein biogenesis Scientific reports 2019
cancer, neuroscience, stem cells, organoids DYRK1A Is a Regulator of S-Phase Entry in Hepatic Progenitor Cells Stem Cells Dev 2018
  Elevated transforming growth factor β signaling activation in β‐actin‐knockout mouse embryonic fibroblasts enhances myofibroblast features Journal of cellular physiology 2018
cancer Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability Molecular cell 2019
virology Endophilin-A2-mediated endocytic pathway is critical for enterovirus 71 entry into caco-2 cells Emerging microbes & … 2019
cancer Endoplasmic reticulum stress precedes oxidative stress in antibiotic-induced cholestasis and cytotoxicity in human hepatocytes Free Radic Biol Med 2018
  Engineering of a GLP-1 analogue peptide/anti-PCSK9 antibody fusion for type 2 diabetes treatment Scientific reports 2018
cancer Exploration of the chondrosarcoma metabolome; the mTOR pathway as an important pro-survival pathway J Bone Oncol 2019
cancer, immunotherapy Extracellular DNA promotes colorectal tumor cell survival after cytotoxic chemotherapy J Surg Res 2018
cancer, stem cells Extracellular vesicles induce minimal hepatotoxicity and immunogenicity Nanoscale 2019
cancer Functional characterization of glucocorticoid receptor variants is required to avoid misinterpretation of NGS data J Endocr Soc 2019
cancer Functional Comparison of XPF Missense Mutations Associated to Multiple DNA Repair Disorders Genes 2019
virology Functional insights into the adjacent stem-loop in honey bee dicistroviruses that promotes internal ribosome entry site-mediated translation and viral infection Journal of virology 2018
cancer Functional regulation of human trophoblast cells by CSE1L J Matern Fetal Neonatal Med 2019
  Fuzhenghuayu Decoction ameliorates hepatic fibrosis by attenuating experimental sinusoidal capillarization and liver angiogenesis Scientific Reports 2019
neuroscience, stem cells FZD4 marks lateral plate mesoderm and signals with NORRIN to increase cardiomyocyte induction from pluripotent stem cell-derived cardiac progenitors Stem Cell Reports 2018
cancer, neuroscience, stem cells Genes and pathways regulated by androgens in human neural cells, potential candidates for the male excess in autism spectrum disorder Biol Psychiatry 2018
cancer, stem cells Genetic and chemical screenings identify HDAC3 as a key regulator in hepatic differentiation of human pluripotent stem cells Stem Cell Reports 2018
cancer Glutathione accelerates osteoclast differentiation and inflammatory bone destruction Free Radical Res 2019
cancer, stem cells Glycylglycine plays critical roles in the proliferation of spermatogonial stem cells Molecular Med Rep 2019
neuroscience GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis Cell 2019
cancer High content imaging assays for IL-6-induced STAT3 pathway activation in head and neck cancer cell lines Method Mol Bio 2018
cancer, virology High content positional biosensor assay to screen for compounds that prevent or disrupt androgen receptor and transcription intermediary factor 2 protein-protein … Method Mol Bio 2018
cancer, neuroscience High content screening in NHBE cells shows significantly reduced biological activity of flavoured e-liquids, when compared to cigarette smoke condensate Toxicology in Vitro 2019
cancer, stem cells High content screening of patient-derived cell lines highlights the potential of non-standard chemotherapeutic agents for the treatment of glioblastoma PloS One 2018
cancer, neuroscience High glucose triggers nucleotide imbalance through O-GlcNAcylation of key enzymes and induces KRAS mutation in pancreatic cells Cell Metabolism 2019
cancer, neuroscience High-Content Imaging of Immunofluorescently Labeled TRPV1-Positive Sensory Neurons Method Mol Bio 2019
stem cells, organoids High-content phenotypic assay for proliferation of human iPSC-derived cardiomyocytes identifies L-type calcium channels as targets Journal of Molecular and Cell Cardiol 2019
neuroscience, stem cells High‐throughput identification of factors promoting neuronal differentiation of human neural progenitor cells in microscale 3D cell culture Biotechnology and Bioeng 2019
cancer, neuroscience, stem cells Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota Nat Commun 2018
cancer, immunotherapy, neuroscience Human corticotrophin releasing factor inhibits cell proliferation and promotes apoptosis through upregulation of tumor protein p53 in human glioma Oncology Letters 2018
stem cells Human pre-valvular endocardial cells derived from pluripotent stem cells recapitulate cardiac pathophysiological valvulogenesis Nat Commun 2019
cancer, neuroscience, stem cells Human-derived neurons and neural progenitor cells in high content imaging applications Method Mol Bio 2018
  Identification and analyses of inhibitors targeting apolipoprotein (a) kringle domains KIV-7, KIV-10, and KV provide insight into kringle domain function Journal of Biological Chemistry 2020
cancer Identification and Validation of Novel Autophagy Regulators Using an Endogenous Readout siGENOME Screen Autophagy 2019
neuroscience, stem cells Identification of amino acid residues of nerve growth factor important for neurite outgrowth in human dorsal root ganglion neurons Eur J Med Chem 2019
cancer, neuroscience, virology Identification of Hsp90 inhibitors with anti-Plasmodium activity Antimicrobial Agents Chemotherapy 2018
stem cells In vivo expansion of functional human hematopoietic stem progenitor cells by butyzamide International Journal of Hematology 2020
cancer, stem cells In-depth proteome analysis highlights HepaRG cells as a versatile cell system surrogate for primary human hepatocytes Cells 2019
cancer, neuroscience Induction of migration of periodontal ligament cells by selective regulation of integrin subunits Journal of Cellular Mol Med 2019
cancer, neuroscience Inflammation kinase PKR phosphorylates α-synuclein and causes α-synuclein-dependent cell death Neurobiology of Disease 2018
cancer, stem cells Inhibition of human prostate cancer (PC-3) cells and targeting of PC-3-derived prostate cancer stem cells with koenimbin, a natural dietary compound from … Drug Design Devel Ther 2018
cancer, neuroscience Inhibition of myostatin signal pathway may be involved in low-intensity pulsed ultrasound promoting bone healing Journal of Medical Ultrason 2019
cancer Inhibition of PARP Sensitizes Chondrosarcoma Cell Lines to Chemo-and Radiotherapy Irrespective of the IDH1 or IDH2 Mutation Status Cancers 2019
neuroscience Inhibition of TBC1D5 activates Rab7a and can enhance the function of the retromer cargo-selective complex J Cell Sci 2018
cancer, neuroscience Inhibition of the MID1 protein complex: a novel approach targeting APP protein synthesis Cell Death Discovery 2018
virology Integrative analysis of Zika virus genome RNA structure reveals critical determinants of viral infectivity Cell Host & Microbe 2018
  Interaction of mycobacteria with Plasmin (ogen) affects phagocytosis and granuloma development Tuberculosis 2019
neuroscience, virology Interferon-induced transmembrane protein 1 restricts replication of viruses that enter cells via the plasma membrane Journal of Virology 2019
cancer KIAA0101 inhibition suppresses cell proliferation and cell cycle progression by promoting the interaction between p53 and Sp1 in breast cancer Biochemical and Biophysical Research  2018
cancer, stem cells KLF4 as a rheostat of osteolysis and osteogenesis in prostate tumors in the bone Oncogene 2019
cancer Knockdown expression of MECR, a novel gene of mitochondrial FAS II inhibits growth and colony-formation, promotes apoptosis of hepatocelluar carcinoma cells Bioscience Trends 2019
cancer Knockdown of CCNO decreases the tumorigenicity of gastric cancer by inducing apoptosis OncoTargets and Ther 2018
cancer, neuroscience Knockdown of HSDL2 inhibits lung adenocarcinoma progression via down-regulating AKT2 expression Bioscience Reports 2020
cancer Knockdown of PSMC3IP suppresses the proliferation and xenografted tumorigenesis of hepatocellular carcinoma cell Journal of Cellular Biochem 2019
cancer, stem cells Knockdown of ubiquitin associated protein 2-like (UBAP2L) inhibits growth and metastasis of hepatocellular carcinoma Medical Science Monitor  2018
cancer, immunotherapy, neuroscience Kushenol E inhibits autophagy and impairs lysosomal positioning via VCP/p97 inhibition Biochemical Pharmacol 2020
cancer, neuroscience, stem cells Lack of Fgf18 causes abnormal clustering of motor nerve terminals at the neuromuscular junction with reduced acetylcholine receptor clusters Scientific Reports 2018
cancer, virology Lentivirus mediated γ-interferon-inducible lysosomal thiol reductase (GILT) knockdown suppresses human glioma U373MG cell proliferation Biochem Biophys Res Commun 2019
cancer LIMD 1 phosphorylation in mitosis is required for mitotic progression and its tumor‐suppressing activity FEBS 2019
cancer, neuroscience, virology LINE-1 protein localization and functional dynamics during the cell cycle Elife 2018
cancer, neuroscience Lipidic synthetic alkaloids as SK3 channel modulators. Synthesis and biological evaluation of 2-substituted tetrahydropyridine derivatives with potential anti-metastatic … European Journal of Med Chem 2020
  Live-cell measurements of kinase activity in single cells using translocation reporters Nature Protocols 2018
stem cells Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation Nature 2019
virology Magnitude and diversity of immune response to vaccinia virus is dependent on route of administration Virology 2020
cancer MAT2B expression correlates with poor prognosis in triple-negative breast cancer Cancer Management and Research 2019
cancer, stem cells, organoids MDH1 and MPP7 regulate autophagy in pancreatic ductal adenocarcinoma Cancer Research 2019
cancer MicroRNA-27a controls the intracellular survival of Mycobacterium tuberculosis by regulating calcium-associated autophagy Nature Comms 2018
cancer, stem cells Microscopy-based high-throughput assays enable multi-parametric analysis to assess adverse effects of nanomaterials in various cell lines Archives of Tox 2018
cancer, stem cells miR-122 release in exosomes precedes overt tolvaptan-induced necrosis in a primary human hepatocyte micropatterned coculture model Toxicological Sci 2018
cancer, neuroscience miR-122-5p Expression and Secretion in Melanoma Cells Is Amplified by the LPAR3 SH3–Binding Domain to Regulate Wnt1 Molecular Cancer Res 2019
  miR-182-3p/Myadm contribute to pulmonary artery hypertension vascular remodeling via a KLF4/p21-dependent mechanism Theranostics 2020
cancer, stem cells miR-211 sponges lncRNA MALAT1 to suppress tumor growth and progression through inhibiting PHF19 in ovarian carcinoma The FASEB Journal 2018
cancer, neuroscience Mitochondria are transported along microtubules in membrane nanotubes to rescue distressed cardiomyocytes from apoptosis Cell Death & Disease 2018
cancer Monosomy 18p is a risk factor for facioscapulohumeral dystrophy Journal of Medical Genetics 2018
cancer, neuroscience MTP18 is a Novel Regulator of Mitochondrial Fission in CNS Neuron Development, Axonal Growth, and Injury Responses Scientific Reports 2019
cancer Muscarinic acetylcholine type 1 receptor activity constrains neurite outgrowth by inhibiting microtubule polymerization and mitochondrial trafficking in adult … Frontiers in Neuroscience 2018
cancer, neuroscience Muscarinic receptor antagonists activate ERK-CREB signaling to augment neurite outgrowth of adult sensory neurons Neuropharmacology 2018
cancer, stem cells NaCl nanoparticles as a cancer therapeutic Advanced Materials 2019
cancer, neuroscience N-Acyldopamine induces aggresome formation without proteasome inhibition and enhances protein aggregation via p62/SQSTM1 expression Scientific Reports 2018
  Nanoscale coupling of endocytic pit growth and stability Science Adv 2019
cancer, neuroscience NHE5 regulates growth factor signaling, integrin trafficking, and degradation in glioma cells Clinical & Experimental Metastasis 2019
cancer, neuroscience, stem cells Novel 3D liquid cell culture method for anchorage-independent cell growth, cell imaging and automated drug screening Scientific Reports 2018
cancer, neuroscience Nuclear myosin 1 activates p21 gene transcription in response to DNA damage through a chromatin-based mechanism Communications Biology 2020
cancer, virology Optimization-by-design of hepatotropic lipid nanoparticles targeting the sodium-taurocholate cotransporting polypeptide eLife 2019
cancer Panduratin A induces protective autophagy in melanoma via the AMPK and mTOR pathway Phytomedicine 2018
cancer, neuroscience, stem cells Per-and polyfluoroalkyl substances impact human spermatogenesis in a stem-cell-derived model Systems Biology in Reprod Med 2018
cancer, neuroscience, stem cells Phenotypic and functional characteristics of human Schwann cells as revealed by cell-based assays and RNA-seq Molecular Neurobiology 2018
cancer Plagioneurin B, a potent isolated compound induces apoptotic signalling pathways and cell cycle arrest in ovarian cancer cells Apoptosis 2018
cancer, neuroscience, stem cells PP2A inhibition sensitizes cancer stem cells to ABL tyrosine kinase inhibitors in BCR-ABL+ human leukemia Science Translational Med 2018
cancer, neuroscience Preclinical evaluation of a GFRA1 targeted antibody-drug conjugate in breast cancer Oncotarget 2018
  Pro-inflammatory cytokines enhance dilatation of bile canaliculi caused by cholestatic antibiotics Toxicology in Vitro 2019
cancer Protein kinase A activation inhibits DUX4 gene expression in myotubes from patients with facioscapulohumeral muscular dystrophy Journal of Biological Chemistry 2018
cancer, neuroscience, stem cells Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice Human Molecular Genetics 2018
  Ptr/CTL0175 is required for the efficient recovery of Chlamydia trachomatis from stress induced by gamma-interferon Frontiers in Microbiology 2019
cancer Pu-erh tea relaxes the thoracic aorta of rats by reducing intracellular calcium Front Pharmacol 2019
  Quercetin protect cigarette smoke extracts induced inflammation and apoptosis in RPE cells Artif Cells Nanomed Biotechnol 2019
cancer RBM17 controls apoptosis and proliferation to promote Glioma progression Biochem Biophys Res Commun 2018
cancer, neuroscience Real-time monitoring of DNA G-quadruplexes in living cells with a small-molecule fluorescent probe Nucleic Acids Research 2018
cancer, neuroscience, stem cells, organoids Recent Advances in Microfluidic Techniques for Systems Biology Analytical Chemistry 2018
cancer Regulation of PRMT5–MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma PNAS 2019
cancer, neuroscience, stem cells Repression of somatic genes by selective recruitment of HDAC3 by BLIMP1 is essential for mouse primordial germ cell fate determination Cell Reports 2018
cancer, neuroscience Reversine inhibits colon carcinoma cell migration by targeting JNK1 Scientific Reports 2018
cancer Role of miR‑449b‑3p in endometriosis via effects on endometrial stromal cell proliferation and angiogenesis Molecular Medicine Reports 2018
cancer, neuroscience RPEL-family rhoGAPs link Rac/Cdc42 GTP loading to G-actin availability Nature Cell Biology 2019
cancer, neuroscience Severe PATCHED1 deficiency in cancer-prone Gorlin patient cells results in intrinsic radiosensitivity Int J Radiat Oncol Biol Phys 2018
cancer, neuroscience Soluble laminin polymers enhance axon growth of primary neurons in vitro Journal of Biomedical Chemistry 2018
neuroscience Specific Knockdown of α-Synuclein by Peptide-Directed Proteasome Degradation Rescued Its Associated Neurotoxicity Cell Chemical 2020
cancer Spontaneous Extracellular Matrix Accumulation in a Human in vitro Model of Renal Fibrosis Is Mediated by αV Integrins Nephron 2019
cancer Stable Redox-Cycling Nitroxide Tempol Has Antifungal and Immune-Modulatory Properties Frontiers in Microbiology 2019
cancer Staphylococcus aureus induces DNA damage in host cell Scientific Reports 2019
cancer, neuroscience Structural analysis and cellular visualization of APP RNA G-quadruplex Chemical Science 2019
stem cells Suppression of adipocyte differentiation by low‐intensity pulsed ultrasound via inhibition of insulin signaling and promotion of CCN family protein 2 Journal of Cellular Biochem 2020
cancer Suppression of CCT3 inhibits malignant proliferation of human papillary thyroid carcinoma cell Oncology Letters 2018
cancer Synthesis and evaluation of 1, 3, 4-oxadiazole derivatives for development as broad-spectrum antibiotics Bioorganic & Medicinal Chem 2019
cancer, neuroscience Synthetic probe development for measuring single or few-cell activity and efflux Methods in Enzymology 2019
  Systems toxicology assessment of a representative e-liquid formulation using human primary bronchial epithelial cells Toxicology Reports 2020
neuroscience, stem cells, organoids Testing for developmental neurotoxicity using a battery of in vitro assays for key cellular events in neurodevelopment Toxicology and Applied Pharmcol 2018
cancer TFIIA transcriptional activity is controlled by a 'cleave-and-run'Exportin-1/Taspase 1-switch Journal of Molecular Cell Bio 2018
cancer TGFβ promotes genomic instability after loss of RUNX3 Cancer Research 2018
stem cells thalidomide inhibits Human ipSc Mesendoderm Differentiation by Modulating cRBn-dependent Degradation of SALL4 Scientific Reports 2020
cancer, neuroscience, stem cells The AMPK/p27Kip1 axis regulates autophagy/apoptosis decisions in aged skeletal muscle stem cells Stem Cell Reports 2018
cancer The antimalarial drug mefloquine enhances TP53 premature termination codon readthrough by aminoglycoside G418 PloS One 2019
cancer, neuroscience The biological effects of long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product Toxicology in Vitro 2018
cancer, stem cells The Cdkn1aSUPER Mouse as a Tool to Study p53-Mediated Tumor Suppression Cell Reports 2018
cancer, neuroscience, stem cells The dynamics of TGF-β signaling are dictated by receptor trafficking via the ESCRT machinery Cell Reports 2018
cancer, neuroscience The effect of Jun dimerization on neurite outgrowth and motif binding Molecular and Cellular Neuroscience 2018
cancer The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma Oncogene 2018
cancer The lead optimization of the polyamine conjugate of flavonoid with a naphthalene motif: Synthesis and biological evaluation European Journal of Med Chem 2018
cancer, neuroscience The relative composition of actin isoforms regulates cell surface biophysical features and cellular behaviors Biochimica et Biophysica  2018
  The secreted protein kinase CstK from Coxiella burnetii influences vacuole development and interacts with the GTPase-activating host protein TBC1D5 Journal of Biological Chemistry 2020
cancer The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells Bioorganic & Medicinal  Chemistry 2019
neuroscience, stem cells Tilianin mediates neuroprotection against ischemic injury by attenuating CaMKII-dependent mitochondrion-mediated apoptosis and MAPK/NF-κB signaling Life Sciences 2019
cancer, neuroscience, stem cells Tools to measure cell health and cytotoxicity using high content imaging and analysis Methods Mol Biol 2018
neuroscience, stem cells Transcriptomically Guided Mesendoderm Induction of Human Pluripotent Stem Cells Using a Systematically Defined Culture Scheme Stem Cell Reports 2019
virology Transmission of Cricket paralysis virus via exosome-like vesicles during infection of Drosophila cells Scientific Reports 2018
neuroscience Triclosan Affects Ca2+ Regulatory Module and Musculature Development in Skeletal Myocyte during Early Life Stages of Zebrafish (Danio rerio) Environmental Science & Technology 2019
cancer UBE2S promotes the proliferation and survival of human lung adenocarcinoma cells BMB reports 2018
cancer, neuroscience UBQLN4 represses homologous recombination and is overexpressed in aggressive tumors Cell 2019
neuroscience Unconventional secretion factor GRASP55 is increased by pharmacological unfolded protein response inducers in neurons Scientific Reports 2019
cancer, neuroscience Vitegnoside Mitigates Neuronal Injury, Mitochondrial Apoptosis, and Inflammation in an Alzheimer's Disease Cell Model via the p38 MAPK/JNK Pathway Journal of Alzheimer's Dis 2019
cancer Wee1 inhibitor AZD1775 effectively inhibits the malignant phenotypes of esophageal squamous cell carcinoma in vitro and in vivo Frontiers in Pharmacol 2019
cancer YAP1 is an independent prognostic marker in pancreatic cancer and associated with extracellular matrix remodeling Journal of Transl Med 2020
cancer, stem cells YES1 is a targetable oncogene in cancers harboring YES1 gene amplification Cancer Research 2019
cancer, neuroscience, stem cells β-Actin–dependent global chromatin organization and gene expression programs control cellular identity The FASEB Journal 2018

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Application Title Source Year
cancer, neuroscience, stem cells, virology Commentary on, “Generation of Three-dimensional Human Neuronal Cultures: Application to Modeling CNS Viral Infections” Journal of Infectiology 2019
cancer, neuroscience Competitive inhibition by NAG-1/GDF-15 NLS peptide enhances its anti-cancer activity Biochem Biophys Res Commun 2019
cancer, immunotherapy Development of in vitro immune effector function assays to better approximate the in vivo behavior of biotherapeutics and cell therapies Journal for ImmunoTherapy of Cancer 2019
cancer, neuroscience, stem cells Effects of hypoxia and ASIC3 on nucleus pulposus cells: from cell behavior to molecular mechanism Biomedicine & Pharmcotherapy 2019
cancer, neuroscience, stem cells, organoids Review of high-content screening applications in toxicology Archives of Toxicology 2019
cancer, neuroscience, stem cells, organoids Shedding light on microRNA function via microscopy-based screening Methods 2019
stem cells thalidomide inhibits Human ipSc Mesendoderm Differentiation by Modulating cRBn-dependent Degradation of SALL4 Scientific Reports 2020

No records were found matching your criteria

Application Title Source Year
cancer, neuroscience A combined cellomics and proteomics approach to uncover neuronal pathways to psychiatric disorder Neuroproteomics 2019
cancer A lung/liver-on-a-chip platform for acute and chronic toxicity studies Lab on a Chip 2018
cancer, immunotherapy, neuroscience, stem cells A Novel Three-Dimensional Glioma Blood-Brain Barrier Model for High-Throughput Testing of Tumoricidal Capability Frontiers in Oncology 2019
cancer, immunotherapy A novel three-dimensional immune oncology model for high-throughput testing of tumoricidal activity Frontiers in Immunology 2018
cancer A simple pyramid-shaped microchamber towards highly efficient isolation of circulating tumor cells from breast cancer patients Biomed Microdevices 2018
neuroscience Analysis of novel endosome-to-Golgi retrieval genes reveals a role for PLD3 in regulating endosomal protein sorting and amyloid precursor protein … Cellular and Molecular Life … 2018
cancer, neuroscience, stem cells AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A Nature Communication 2018
neuroscience, stem cells, virology Atovaquone inhibits arbovirus replication through the depletion of intracellular nucleotides Journal of Virology 2019
neuroscience, stem cells Beyond 2D: effects of photobiomodulation in 3D tissue-like systems Journal of Biomed Opt. 2020
cancer, immunotherapy Boosting Natural Killer Cell-Mediated Targeting of Sarcoma Through DNAM-1 and NKG2D Frontiers in Immunology 2020
cancer, immunotherapy, neuroscience, stem cells, virology Cancer exosomes induce tumor innervation Nature Communication 2018
stem cells Chaperone mediated detection of small molecule target binding in cells Nature Communication 2020
cancer DDIT4 promotes gastric cancer proliferation and tumorigenesis through the p53 and MAPK pathways Cancer Communication 2018
cancer Development of a FRET-Based Assay for Analysis of mAbs Internalization and Processing by Dendritic Cells in Preclinical Immunogenicity Risk Assessment The AAPS Journal 2020
cancer, neuroscience Dopamine increases HIV entry into macrophages by increasing calcium release via an alternative signaling pathway Brain, Behavior, and Immunology 2019
virology Evolution-driven attenuation of alphaviruses highlights key glycoprotein determinants regulating viral infectivity and dissemination Cell Reports 2019
stem cells Extension of maximal lifespan and high bone marrow chimerism after nonmyeloablative syngeneic transplantation of bone marrow from young to old Mice Frontiers in Genetics 2019
  General staining and segmentation procedures for high content imaging and analysis Methods Mol Biol 2018
cancer, neuroscience, stem cells, organoids Generation of three-dimensional human neuronal cultures: application to modeling CNS viral infections Stem Cell Research  2018
cancer, neuroscience Granulovacuolar degeneration bodies are neuron-selective lysosomal structures induced by intracellular tau pathology Acta Neuropathol 2019
cancer, neuroscience High content screening for drug discovery from traditional Chinese medicine Chinese medicine 2019
cancer, neuroscience High levels of PIWI‐interacting RNAs are present in the small RNA landscape of prostate epithelium from vitamin D clinical trial specimens The Prostate 2019
cancer, virology High-Content Screening, a Reliable System for Coxiella burnetii Isolation from Clinical Samples Journal of Clinical Microbiol 2020
cancer, neuroscience High-Throughput Fluorescence Assays for Ion Channels and GPCRs Adv Exp Med Biol 2020
virology High-throughput isolation of giant viruses using high-content screening Communications Biology 2019
  In Vitro High-Content Imaging-Based Phenotypic Analysis of Bronchial 3D Organotypic Air–Liquid Interface Cultures SLAS 2020
cancer, neuroscience, stem cells In vitro screening platforms for identifying autophagy modulators in mammalian cells Autophagy 2019
neuroscience Inhibition of TBC1D5 activates Rab7a and can enhance the function of the retromer cargo-selective complex J Cell Sci 2018
cancer, neuroscience Isoscoparins R and S, two new ent-clerodane diterpenoids from Isodon scoparius Journal Asian Nat Prod Res 2019
cancer, neuroscience MARCKS regulates neuritogenesis and interacts with a CDC42 signaling network Scientific reports 2018
neuroscience, stem cells, organoids Modeling Leigh syndrome using patient-specific induced pluripotent stem cells Osaka City Med J 2019
  Modular, defined assembly of antibody-based constructs using click chemistry Keystone Symposia 2018
neuroscience Modulation of CRMP2 via (S)-Lacosamide shows therapeutic promise but is ultimately ineffective in a mouse model of CLN6-Batten disease Health Psychol Behav Med 2019
cancer, neuroscience New insights into mechanism of bisphenol analogue neurotoxicity: implications of inhibition of O-GlcNAcase activity in PC12 cells Archives of Toxicology 2019
cancer, neuroscience No evidence for cell‐to‐cell transmission of the unfolded protein response in cell culture Journal of Neurochem 2019
cancer Non-Toxic and Ultra-Small Biosilver Nanoclusters Trigger Apoptotic Cell Death in Fluconazole-Resistant Candida albicans via Ras Signaling Biomolecules 2019
cancer, neuroscience OPTN recruitment to a Golgi-proximal compartment regulates immune signalling and cytokine secretion Journal of Cell Science 2020
neuroscience, stem cells Partial FMRP expression is sufficient to normalize neuronal hyperactivity in Fragile X neurons European Journal of Neuroscience 2019
cancer, neuroscience Phosphorylation of syntaxin 17 by TBK1 controls autophagy initiation Developmental Cell 2019
cancer, neuroscience, stem cells Population-based analysis of BAP1 germline variations in patients with uveal melanoma Human Molecular Genetics 2019
cancer, immunotherapy, stem cells, organoids Replication Study: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment eLife 2019
cancer, neuroscience, stem cells, organoids Review of high-content screening applications in toxicology Archives of Toxicology 2019
neuroscience Role of the AP-5 adaptor protein complex in late endosome-to-Golgi retrieval PLoS Biol 2018
cancer, neuroscience, stem cells, organoids Shedding light on microRNA function via microscopy-based screening Methods 2019
  Super-multiplexed fluorescence microscopy via photostability contrast Biomedical optics  2018
stem cells thalidomide inhibits Human ipSc Mesendoderm Differentiation by Modulating cRBn-dependent Degradation of SALL4 Scientific Reports 2020
cancer, virology The ETS transcription factor ELF1 regulates a broadly antiviral program distinct from the type I interferon response PLoS Pathog 2019
  The WDR11 complex facilitates the tethering of AP-1-derived vesicles Nature Communication 2018
cancer Tools to measure autophagy using high content imaging and analysis Methods Mol Biol 2018
cancer, neuroscience Unconventional secretion factor GRASP55 is increased by pharmacological unfolded protein response inducers in neurons Scientific Reports 2019
cancer Vitamin D regulates prostate cell metabolism via genomic and non-genomic mitochondrial redox-dependent mechanisms The Journal of Steroid Biochemistry and Molecular … 2019
cancer, immunotherapy Wedge-shaped microfluidic chip for circulating tumor cells isolation and its clinical significance in gastric cancer Journal Transl Med 2018

No records were found matching your criteria

Application Title Source Year
virology A Hyperstabilizing Mutation in the Base of the Ebola Virus Glycoprotein Acts at Multiple Steps To Abrogate Viral Entry Molecular Biology of the Cell 2018
neuroscience A novel inhibitor of inducible NOS dimerization protects against cytokine‐induced rat beta cell dysfunction Br J Pharmacol 2018
virology A novel piperazine-based drug lead for cryptosporidiosis from the medicines for malaria venture open-access malaria box Antimicrob Agents Chemother 2018
cancer, neuroscience Activated heterotrimeric G protein αi subunits inhibit Rap-dependent cell adhesion and promote cell migration J Biol Chem 2018
cancer, immunotherapy ADME/toxicity prediction and antitumor activity of novel nitrogenous heterocyclic compounds designed by computer targeting of alkylglycerone phosphate … Oncol Lett 2020
stem cells Advances in antiwolbachial drug discovery for treatment of parasitic filarial worm infections Trop Med Infect Dis 2020
cancer, neuroscience Analysis of Gene Expression and Neuronal Phenotype in Neuroscreen-1 (NS-1) Cells Int J Biomed Investig 2019
cancer Bifunctional Au-templated RNA nanoparticles enable direct cell uptake detection and GRP75 knockdown in prostate cancer J Mater Chem B 2018
neuroscience, stem cells, virology C9orf72-generated poly-GR and poly-PR do not directly interfere with nucleocytoplasmic transport Sci Rep 2019
immunotherapy, virology Convergent Structures Illuminate Features for Germline Antibody Binding and Pan-Lassa Virus Neutralization Cell 2018
immunotherapy, virology Design and evaluation of bi-and trispecific antibodies targeting multiple filovirus glycoproteins J Biol Chem 2019
neuroscience, stem cells Differential effects of glucose deprivation on the survival of fetal versus adult neural stem cells‐derived oligodendrocyte precursor cells Glia 2018
  DMN-Tre Labeling for Detection and High-Content Screening of Compounds against Intracellular Mycobacteria ACS Omega 2018
cancer Downregulation of MicroRNA-4463 Attenuates High-Glucose-and Hypoxia-Induced Endothelial Cell Injury by Targeting PNUTS Cell Physiol Biochem 2019
cancer, organoids eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma Nature Communication 2018
cancer Enhanced cancer theranostics with self-assembled, multilabeled siRNAs ACS Omega 2019
virology Floxed-cassette allelic exchange mutagenesis enables markerless gene deletion in Chlamydia trachomatis and can reverse cassette-induced polar effects J Bacteriol 2020
cancer, virology Fluorescently Labeled siRNAs and their Theranostic Applications in Cancer Gene Therapy ACS Omega 2018
neuroscience, stem cells, virology FUS-induced neurotoxicity in Drosophila is prevented by downregulating nucleocytoplasmic transport proteins Hum Mol Genet 2018
cancer, stem cells Genome-Wide Association Study of Diabetogenic Adipose Morphology in the GENetics of Adipocyte Lipolysis (GENiAL) Cohort Cells 2020
cancer, stem cells Glucocorticoids delay RAF-induced senescence promoted by EGR1 J Cell Sci 2018
cancer, stem cells Glutamine Links Obesity to Inflammation in Human White Adipose Tissue Cell Metabolism 2020
cancer, neuroscience, stem cells GRP78 modulates cell adhesion markers in prostate Cancer and multiple myeloma cell lines BMC Cancer 2020
cancer, stem cells GTPBP4 promotes gastric cancer progression via regulating P53 activity Cell Physiol Biochem 2019
cancer, virology Hemagglutinin Cleavability, Acid Stability, and Temperature Dependence Optimize Influenza B Virus for Replication in Human Airways J Virol 2019
cancer Herbicidins from Streptomyces sp. CB01388 Showing Anti-Cryptosporidium Activity J Nat Prod 2019
cancer, neuroscience High content screening for drug discovery from traditional Chinese medicine Chin Med 2018
  High-Content Screening for Cryptosporidium Drug Discovery Methods Mol Biol 2019
cancer Highly Efficient Isolation of Circulating Tumor Cells Using a Simple Wedge-Shaped Microfluidic Device IEEE Trans Biomed Eng 2019
immunotherapy, virology Human monoclonal antibodies against chikungunya virus target multiple distinct epitopes in the E1 and E2 glycoproteins PLOS Pathog 2019
cancer, stem cells Human-specific function of IL-10 in adipose tissue linked to insulin resistance J Clin Endocrinol Metab 2019
cancer, neuroscience, stem cells In vitro screening platforms for identifying autophagy modulators in mammalian cells Methods Mol Biol 2020
cancer, neuroscience Knockdown siRNA targeting the mitochondrial sodium-calcium exchanger-1 inhibits the protective effects of two cannabinoids against acute paclitaxel toxicity J Mol Neurosci 2020
cancer, neuroscience, stem cells MANF ablation causes prolonged activation of the UPR without neurodegeneration in the mouse midbrain dopamine system eNeuro 2019
cancer MicroRNA-27a/b-3p and PPARG regulate SCAMP3 through a feed-forward loop during adipogenesis Sci Rep 2020
cancer, neuroscience Microscopy-based automated live cell screening for small molecules that affect ciliation Front Genet 2020
cancer, immunotherapy, organoids Modular, defined assembly of antibody-based constructs using click chemistry Keystone Symposia 2019
cancer, neuroscience N-substituted phenylbenzamides of the niclosamide chemotype attenuate obesity related changes in high fat diet fed mice PLOS One 2018
cancer PITPNA-AS1 abrogates the inhibition of miR-876-5p on WNT5A to facilitate hepatocellular carcinoma progression Cell Death Dis 2018
cancer, neuroscience, stem cells Possible Strategies to Optimize a Biomarker Discovery Approach to Correlate with Neurological Outcome in Patients with Spinal Cord Injury: A Pilot Study J Neurotrauma 2018
cancer, neuroscience, stem cells Prolactin, Estradiol and Testosterone Differentially Impact Human Hippocampal Neurogenesis in an In Vitro Model Neuroscience 2018
cancer, neuroscience Protective effect of 3-hydroxybutyrate against endoplasmic reticulum stress-associated vascular endothelial cell damage induced by low glucose exposure PLOS One 2018
cancer Pumpless platform for high-throughput dynamic multicellular culture and chemosensitivity evaluation Lab Chip 2019
 stem cells Recombinant extracellular matrix protein fragments support human embryonic stem cell chondrogenesis Tissue Eng Part A 2019
cancer, stem cells, organoids Shedding light on microRNA function via microscopy-based screening Methods 2018
cancer, immunotherapy, virology Structural Basis of Broad Ebolavirus Neutralization by a Human Survivor Antibody Nat Struct Mol Biol 2019
immunotherapy, stem cells, virology Systematic analysis of monoclonal antibodies against Ebola virus GP defines features that contribute to protection Cell 2019
cancer Techniques to Enable 1536-Well Phenotypic Screening Methods Mol Biol 2019
 stem cells The microbiota regulates inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination PNAS 2019
neuroscience, stem cells The role of nuclear receptors in the differentiation of oligodendrocyte precursor cells derived from fetal and adult neural stem cells Stem Cell Res 2019
 stem cells, virology THP-1 and Dictyostelium infection models for screening and characterization of anti-Mycobacterium abscessus hit compounds Antimicrob Agents Chemother 2019
cancer, virology Vesicular Stomatitis Virus-Based Vaccines Provide Cross-Protection against Andes and Sin Nombre Viruses. Viruses 2019

No records were found matching your criteria

Application Title Source Year
cancer, neuroscience, stem cells, organoids, virology A fluorescent cell-based system for imaging Zika virus infection in real-time Viruses 2018
cancer A genome-wide RNAi screen identifies the SMC5/6 complex as a non-redundant regulator of a Topo2a-dependent G2 arrest Nucleic Acids Res 2019
stem cells A head-to-head Caco-2 assay comparison of the mechanisms of action of the intestinal permeation enhancers: SNAC and sodium caprate (C10) European Journal of Pharm Biopharm 2020
  A high content screening assay for identifying inhibitors against active and dormant state intracellular Mycobacterium tuberculosis Journal of Microbiological Methods 2019
cancer, neuroscience A Multi-Omics Interpretable Machine Learning Model Reveals Modes of Action of Small Molecules Scientific Reports 2020
neuroscience A Novel RNA editing sensor tool and a specific agonist determine neuronal protein expression of RNA-edited glycine receptors and identify a genomic … Frontiers in Molecular Neuro 2018
cancer, stem cells A novel tumor spheroid model identifies selective enhancement of radiation by an inhibitor of oxidative phosphorylation Oncotarget 2019
cancer, neuroscience, stem cells, organoids A SMN2 Splicing Modifier Rescues the Disease Phenotypes in an In Vitro Human Spinal Muscular Atrophy Model Stem Cells and Dev 2019
cancer, neuroscience A stress-enhanced model for discovery of disease-modifying gene: Ece1-suppresses the toxicity of α-synuclein A30P Neurobiology of Disease 2018
cancer, stem cells A β1-tubulin–based megakaryocyte maturation reporter system identifies novel drugs that promote platelet production Blood Adv 2018
cancer, neuroscience Activation of Nrf2 signaling by salvianolic acid C attenuates NF‑κB mediated inflammatory response both in vivo and in vitro Int Immunopharmacol 2018
cancer, virology Advanced identification of global bioactivity hotspots via screening of the metabolic fingerprint of entire ecosystems Scientific Reports 2020
cancer, immunotherapy, stem cells Advanced Materials and Devices for the Regulation and Study of NK Cells International Journal of Molecular Sciences 2019
cancer AMMECR1 Inhibits Apoptosis and Promotes Cell-cycle Progression and Proliferation of the A549 Human Lung Cancer Cell Line Anticancer Res 2019
neuroscience, stem cells An analog derived from phenylpropanoids ameliorates Alzheimer's disease–like pathology and protects mitochondrial function Neurobiology of Aging 2019
cancer, stem cells An endothelial cell/mesenchymal stem cell coculture cord formation assay to model vascular biology in vitro

 

Methods Mol Biol

2018
  Analysis and quantification of oxidized low-density lipoprotein-induced lipid droplets in macrophages through high-content screening: Application for antiatherogenic … Assay and Drug Development Technologies 2019
  Andrographolide protects chondrocytes from oxidative stress injury by activation of the Keap1–Nrf2–Are signaling pathway J Cell Physiol 2019
cancer Anlotinib inhibits synovial sarcoma by targeting GINS1: a novel downstream target oncogene in progression of synovial sarcoma Clinical and Translational Oncology 2019
cancer, immunotherapy, neuroscience Antibody-mediated clearance of tau in primary mouse microglial cultures requires Fcγ-receptor binding and functional lysosomes Scientific Reports 2019
cancer, immunotherapy Anticancer Activity of Earthworm Powder (Lumbricus terrestris) Against MCF-7 and PC-3 Cancer Cell Lines Journal of Gastrointestinal Cancer 2019
  Anti-inflammatory activity of dehydroandrographolide by TLR4/NF-κB signaling pathway inhibition in bile duct-ligated mice Cell Physiol Biochem 2018
cancer, neuroscience Anti-inflammatory effects and mechanism of the total flavonoids from Artemisia scoparia Waldst. et kit. in vitro and in vivo Biomed Pharmacother 2018
cancer, stem cells Arrayed functional genetic screenings in pluripotency reprogramming and differentiation Stem Cell Research & Therapy 2019
stem cells Aryl hydrocarbon receptor modulation by tuberculosis drugs impairs host defense and treatment outcomes Cell Host & Microbe 2020
cancer Assessment of novel tobacco heating product THP1. 0. Part 6: a comparative in vitro study using contemporary screening approaches Regul Toxicol Pharmacol 2018
cancer ATG7 and ATG9A loss-of-function variants trigger autophagy impairment and ovarian failure Genetic Med 2019
cancer Automated Detection of Autophagy Response Using Single Cell-Based Microscopy Assays Autophagy 2019
cancer, neuroscience, stem cells Autophagy contributes to BMP type 2 receptor degradation and development of pulmonary arterial hypertension J Pathology 2019
cancer, immunotherapy, stem cells B591, a novel specific pan-PI3K inhibitor, preferentially targets cancer stem cells Oncogene 2019
cancer BAI1‑associated protein 2‑like 2 is a potential biomarker in lung cancer Oncology Report 2019
cancer, neuroscience, stem cells BCL2 and BCL (X) L selective inhibitors decrease mitochondrial ATP production in breast cancer cells and are synthetically lethal when combined with 2 … Oncotarget 2018
neuroscience Benzalkonium chloride-induced direct and indirect toxicity on corneal epithelial and trigeminal neuronal cells: proinflammatory and apoptotic responses in vitro Toxicology letters 2020
cancer, neuroscience Bioinspired Honokiol Analogs and Their Evaluation for Activity on the Norepinephrine Transporter Molecules 2018
neuroscience Blue light exposure in vitro causes toxicity to trigeminal neurons and glia through increased superoxide and hydrogen peroxide generation Free Radic Biol Med 2019
  Breast Milk and Saliva Lactoferrin Levels and Postnatal Cytomegalovirus Infection Am J Perinatol 2020
cancer, stem cells Cardiac Toxicity From Ethanol Exposure in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Toxicol Sci 2019
cancer, immunotherapy Casein Kinase 2 Interacting Protein-1 Suppresses Glioma Cell Proliferation via Regulating the AKT/GSK3/-Catenin Pathway Biomed Res Int 2019
cancer, stem cells Cell-Based High Content Analysis of Cell Proliferation and Apoptosis High Content Screening 2018
cancer, neuroscience Cell‐based high‐throughput screen for small molecule inhibitors of Bax translocation J Cell Mol Med 2019
cancer Cellular fluorescein hyperfluorescence is dynamin-dependent and increased by Tetronic 1107 treatment Int J Biochem Cell Biol 2018
cancer Chlamydia trachomatis fails to protect its growth niche against pro-apoptotic insults Cell Death Differ 2019
cancer Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion Autophagy 2018
cancer, immunotherapy CIZ1 knockdown suppresses the proliferation of bladder cancer cells by inducing apoptosis Gene 2019
cancer Combined PPARγ activation and XIAP inhibition as a potential therapeutic strategy for ovarian granulosa cell tumors Mol Cancer Therap 2019
cancer, stem cells, virology Compounds producing an effective combinatorial regimen for disruption of HIV‐1 latency EMBO Mol Med 2018
cancer Conjugate Polyplexes with Anti-Invasive Properties and Improved siRNA Delivery In Vivo Bioconjugate Chemistry 2018
cancer, neuroscience, stem cells, organoids Constitutive Activity of a G Protein‐Coupled Receptor, DRD1, Contributes to Human Cerebral Organoid Formation STEM CELLS 2020
cancer, neuroscience CoQ10 ameliorates mitochondrial dysfunction in diabetic nephropathy through mitophagy J Endocrinol  
cancer, neuroscience Cyclin-dependent kinase 18 controls trafficking of aquaporin-2 and its abundance through ubiquitin ligase STUB1, which functions as an AKAP Cells 2020
cancer Cyclodextrin-and dendrimer-conjugated graphene oxide as a nanocarrier for the delivery of selected chemotherapeutic and photosensitizing agents Mater Sci Eng C Mater Biol Appl 2018
cancer, neuroscience, stem cells Cytotoxic Mechanism for Silver Nanoparticles Based High-Content Cellomics and Transcriptome Sequencing J Biomed Nanotechnol 2019
cancer Delivery of miR-146a to Ly6Chigh monocytes inhibits pathogenic bone erosion in inflammatory arthritis Theranostics 2018
cancer, neuroscience, stem cells Detection of Rare Objects by Flow Cytometry: Imaging, Cell Sorting, and Deep Learning Approaches Intl J Mol Science 2020
cancer Development and application of high-content biological screening for modulators of NET production Frontiers in Immunol 2018
  Development and optimization of a miniaturized western blot-based screening platform to identify regulators of post-translational modifications High-throughput 2019
neuroscience Development of a cell-based assay to assess binding of the proNGF prodomain to sortilin Cell Mol Neuro  2018
cancer, immunotherapy, stem cells, virology Development of a novel screening platform for the identification of small molecule inhibitors of human adenovirus Virology 2019
cancer, neuroscience, stem cells Development of Human in vitro Brain-blood Barrier Model from Induced Pluripotent Stem Cell-derived Endothelial Cells to Predict the in vivo Permeability of Drugs Neuroscience Bull 2019
cancer Diazinon exposure activated transcriptional factors CCAAT-enhancer-binding proteins α (C/EBPα) and peroxisome proliferator-activated receptor γ (PPARγ) and … Pesticide Biochemistry and Physiology 2018
  Differentiated mitochondrial function in mouse 3T3 fibroblasts and human epithelial or endothelial cells in response to chemical exposure Basic Clin Pharmacol Toxicol 2019
cancer Differentiation of Aneugens and Clastogens in the In Vitro Micronucleus Test by Kinetochore Scoring Using Automated Image Analysis Environ Mol Mutagen 2019
neuroscience Direct, gabapentin-insensitive interaction of a soluble form of the calcium channel subunit α 2 δ-1 with thrombospondin-4 Scientific Reports 2019
cancer Discovery of the first potent, selective, and orally bioavailable Signal Peptide Peptidase-Like 2a (SPPL2a) inhibitor displaying pronounced immunomodulatory effects … J Med Chem 2018
cancer Discovery of the Polyamine Conjugate with Benzo[cd]indol-2(1H)-one as a Lysosome-Targeted Antimetastatic Agent J Med Chem 2018
cancer, neuroscience Downregulation of CPA4 inhibits non small–cell lung cancer growth by suppressing the AKT/c‐MYC pathway Mol Carcinogen 2019
cancer Downregulation of RNA binding motif protein 17 expression inhibits proliferation of hypopharyngeal carcinoma FaDu cells Oncology 2018
cancer, neuroscience Downregulation of SNRPG induces cell cycle arrest and sensitizes human glioblastoma cells to temozolomide by targeting Myc through a p53-dependent … Cancer Biol Med 2020
cancer, immunotherapy, neuroscience Drug discovery technologies: Caenorhabditis elegans as a model for anthelmintic therapeutics Med Res Rev 2020
virology Dual roles for the ER membrane protein complex in flavivirus infection: viral entry and protein biogenesis Scientific reports 2019
cancer, neuroscience, stem cells, organoids DYRK1A Is a Regulator of S-Phase Entry in Hepatic Progenitor Cells Stem Cells Dev 2018
  Elevated transforming growth factor β signaling activation in β‐actin‐knockout mouse embryonic fibroblasts enhances myofibroblast features Journal of cellular physiology 2018
cancer Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability Molecular cell 2019
virology Endophilin-A2-mediated endocytic pathway is critical for enterovirus 71 entry into caco-2 cells Emerging microbes & … 2019
cancer Endoplasmic reticulum stress precedes oxidative stress in antibiotic-induced cholestasis and cytotoxicity in human hepatocytes Free Radic Biol Med 2018
  Engineering of a GLP-1 analogue peptide/anti-PCSK9 antibody fusion for type 2 diabetes treatment Scientific reports 2018
cancer Exploration of the chondrosarcoma metabolome; the mTOR pathway as an important pro-survival pathway J Bone Oncol 2019
cancer, immunotherapy Extracellular DNA promotes colorectal tumor cell survival after cytotoxic chemotherapy J Surg Res 2018
cancer, stem cells Extracellular vesicles induce minimal hepatotoxicity and immunogenicity Nanoscale 2019
cancer Functional characterization of glucocorticoid receptor variants is required to avoid misinterpretation of NGS data J Endocr Soc 2019
cancer Functional Comparison of XPF Missense Mutations Associated to Multiple DNA Repair Disorders Genes 2019
virology Functional insights into the adjacent stem-loop in honey bee dicistroviruses that promotes internal ribosome entry site-mediated translation and viral infection Journal of virology 2018
cancer Functional regulation of human trophoblast cells by CSE1L J Matern Fetal Neonatal Med 2019
  Fuzhenghuayu Decoction ameliorates hepatic fibrosis by attenuating experimental sinusoidal capillarization and liver angiogenesis Scientific Reports 2019
neuroscience, stem cells FZD4 marks lateral plate mesoderm and signals with NORRIN to increase cardiomyocyte induction from pluripotent stem cell-derived cardiac progenitors Stem Cell Reports 2018
cancer, neuroscience, stem cells Genes and pathways regulated by androgens in human neural cells, potential candidates for the male excess in autism spectrum disorder Biol Psychiatry 2018
cancer, stem cells Genetic and chemical screenings identify HDAC3 as a key regulator in hepatic differentiation of human pluripotent stem cells Stem Cell Reports 2018
cancer Glutathione accelerates osteoclast differentiation and inflammatory bone destruction Free Radical Res 2019
cancer, stem cells Glycylglycine plays critical roles in the proliferation of spermatogonial stem cells Molecular Med Rep 2019
neuroscience GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis Cell 2019
cancer High content imaging assays for IL-6-induced STAT3 pathway activation in head and neck cancer cell lines Method Mol Bio 2018
cancer, virology High content positional biosensor assay to screen for compounds that prevent or disrupt androgen receptor and transcription intermediary factor 2 protein-protein … Method Mol Bio 2018
cancer, neuroscience High content screening in NHBE cells shows significantly reduced biological activity of flavoured e-liquids, when compared to cigarette smoke condensate Toxicology in Vitro 2019
cancer, stem cells High content screening of patient-derived cell lines highlights the potential of non-standard chemotherapeutic agents for the treatment of glioblastoma PloS One 2018
cancer, neuroscience High glucose triggers nucleotide imbalance through O-GlcNAcylation of key enzymes and induces KRAS mutation in pancreatic cells Cell Metabolism 2019
cancer, neuroscience High-Content Imaging of Immunofluorescently Labeled TRPV1-Positive Sensory Neurons Method Mol Bio 2019
stem cells, organoids High-content phenotypic assay for proliferation of human iPSC-derived cardiomyocytes identifies L-type calcium channels as targets Journal of Molecular and Cell Cardiol 2019
neuroscience, stem cells High‐throughput identification of factors promoting neuronal differentiation of human neural progenitor cells in microscale 3D cell culture Biotechnology and Bioeng 2019
cancer, neuroscience, stem cells Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota Nat Commun 2018
cancer, immunotherapy, neuroscience Human corticotrophin releasing factor inhibits cell proliferation and promotes apoptosis through upregulation of tumor protein p53 in human glioma Oncology Letters 2018
stem cells Human pre-valvular endocardial cells derived from pluripotent stem cells recapitulate cardiac pathophysiological valvulogenesis Nat Commun 2019
cancer, neuroscience, stem cells Human-derived neurons and neural progenitor cells in high content imaging applications Method Mol Bio 2018
  Identification and analyses of inhibitors targeting apolipoprotein (a) kringle domains KIV-7, KIV-10, and KV provide insight into kringle domain function Journal of Biological Chemistry 2020
cancer Identification and Validation of Novel Autophagy Regulators Using an Endogenous Readout siGENOME Screen Autophagy 2019
neuroscience, stem cells Identification of amino acid residues of nerve growth factor important for neurite outgrowth in human dorsal root ganglion neurons Eur J Med Chem 2019
cancer, neuroscience, virology Identification of Hsp90 inhibitors with anti-Plasmodium activity Antimicrobial Agents Chemotherapy 2018
stem cells In vivo expansion of functional human hematopoietic stem progenitor cells by butyzamide International Journal of Hematology 2020
cancer, stem cells In-depth proteome analysis highlights HepaRG cells as a versatile cell system surrogate for primary human hepatocytes Cells 2019
cancer, neuroscience Induction of migration of periodontal ligament cells by selective regulation of integrin subunits Journal of Cellular Mol Med 2019
cancer, neuroscience Inflammation kinase PKR phosphorylates α-synuclein and causes α-synuclein-dependent cell death Neurobiology of Disease 2018
cancer, stem cells Inhibition of human prostate cancer (PC-3) cells and targeting of PC-3-derived prostate cancer stem cells with koenimbin, a natural dietary compound from … Drug Design Devel Ther 2018
cancer, neuroscience Inhibition of myostatin signal pathway may be involved in low-intensity pulsed ultrasound promoting bone healing Journal of Medical Ultrason 2019
cancer Inhibition of PARP Sensitizes Chondrosarcoma Cell Lines to Chemo-and Radiotherapy Irrespective of the IDH1 or IDH2 Mutation Status Cancers 2019
neuroscience Inhibition of TBC1D5 activates Rab7a and can enhance the function of the retromer cargo-selective complex J Cell Sci 2018
cancer, neuroscience Inhibition of the MID1 protein complex: a novel approach targeting APP protein synthesis Cell Death Discovery 2018
virology Integrative analysis of Zika virus genome RNA structure reveals critical determinants of viral infectivity Cell Host & Microbe 2018
  Interaction of mycobacteria with Plasmin (ogen) affects phagocytosis and granuloma development Tuberculosis 2019
neuroscience, virology Interferon-induced transmembrane protein 1 restricts replication of viruses that enter cells via the plasma membrane Journal of Virology 2019
cancer KIAA0101 inhibition suppresses cell proliferation and cell cycle progression by promoting the interaction between p53 and Sp1 in breast cancer Biochemical and Biophysical Research  2018
cancer, stem cells KLF4 as a rheostat of osteolysis and osteogenesis in prostate tumors in the bone Oncogene 2019
cancer Knockdown expression of MECR, a novel gene of mitochondrial FAS II inhibits growth and colony-formation, promotes apoptosis of hepatocelluar carcinoma cells Bioscience Trends 2019
cancer Knockdown of CCNO decreases the tumorigenicity of gastric cancer by inducing apoptosis OncoTargets and Ther 2018
cancer, neuroscience Knockdown of HSDL2 inhibits lung adenocarcinoma progression via down-regulating AKT2 expression Bioscience Reports 2020
cancer Knockdown of PSMC3IP suppresses the proliferation and xenografted tumorigenesis of hepatocellular carcinoma cell Journal of Cellular Biochem 2019
cancer, stem cells Knockdown of ubiquitin associated protein 2-like (UBAP2L) inhibits growth and metastasis of hepatocellular carcinoma Medical Science Monitor  2018
cancer, immunotherapy, neuroscience Kushenol E inhibits autophagy and impairs lysosomal positioning via VCP/p97 inhibition Biochemical Pharmacol 2020
cancer, neuroscience, stem cells Lack of Fgf18 causes abnormal clustering of motor nerve terminals at the neuromuscular junction with reduced acetylcholine receptor clusters Scientific Reports 2018
cancer, virology Lentivirus mediated γ-interferon-inducible lysosomal thiol reductase (GILT) knockdown suppresses human glioma U373MG cell proliferation Biochem Biophys Res Commun 2019
cancer LIMD 1 phosphorylation in mitosis is required for mitotic progression and its tumor‐suppressing activity FEBS 2019
cancer, neuroscience, virology LINE-1 protein localization and functional dynamics during the cell cycle Elife 2018
cancer, neuroscience Lipidic synthetic alkaloids as SK3 channel modulators. Synthesis and biological evaluation of 2-substituted tetrahydropyridine derivatives with potential anti-metastatic … European Journal of Med Chem 2020
  Live-cell measurements of kinase activity in single cells using translocation reporters Nature Protocols 2018
stem cells Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation Nature 2019
virology Magnitude and diversity of immune response to vaccinia virus is dependent on route of administration Virology 2020
cancer MAT2B expression correlates with poor prognosis in triple-negative breast cancer Cancer Management and Research 2019
cancer, stem cells, organoids MDH1 and MPP7 regulate autophagy in pancreatic ductal adenocarcinoma Cancer Research 2019
cancer MicroRNA-27a controls the intracellular survival of Mycobacterium tuberculosis by regulating calcium-associated autophagy Nature Comms 2018
cancer, stem cells Microscopy-based high-throughput assays enable multi-parametric analysis to assess adverse effects of nanomaterials in various cell lines Archives of Tox 2018
cancer, stem cells miR-122 release in exosomes precedes overt tolvaptan-induced necrosis in a primary human hepatocyte micropatterned coculture model Toxicological Sci 2018
cancer, neuroscience miR-122-5p Expression and Secretion in Melanoma Cells Is Amplified by the LPAR3 SH3–Binding Domain to Regulate Wnt1 Molecular Cancer Res 2019
  miR-182-3p/Myadm contribute to pulmonary artery hypertension vascular remodeling via a KLF4/p21-dependent mechanism Theranostics 2020
cancer, stem cells miR-211 sponges lncRNA MALAT1 to suppress tumor growth and progression through inhibiting PHF19 in ovarian carcinoma The FASEB Journal 2018
cancer, neuroscience Mitochondria are transported along microtubules in membrane nanotubes to rescue distressed cardiomyocytes from apoptosis Cell Death & Disease 2018
cancer Monosomy 18p is a risk factor for facioscapulohumeral dystrophy Journal of Medical Genetics 2018
cancer, neuroscience MTP18 is a Novel Regulator of Mitochondrial Fission in CNS Neuron Development, Axonal Growth, and Injury Responses Scientific Reports 2019
cancer Muscarinic acetylcholine type 1 receptor activity constrains neurite outgrowth by inhibiting microtubule polymerization and mitochondrial trafficking in adult … Frontiers in Neuroscience 2018
cancer, neuroscience Muscarinic receptor antagonists activate ERK-CREB signaling to augment neurite outgrowth of adult sensory neurons Neuropharmacology 2018
cancer, stem cells NaCl nanoparticles as a cancer therapeutic Advanced Materials 2019
cancer, neuroscience N-Acyldopamine induces aggresome formation without proteasome inhibition and enhances protein aggregation via p62/SQSTM1 expression Scientific Reports 2018
  Nanoscale coupling of endocytic pit growth and stability Science Adv 2019
cancer, neuroscience NHE5 regulates growth factor signaling, integrin trafficking, and degradation in glioma cells Clinical & Experimental Metastasis 2019
cancer, neuroscience, stem cells Novel 3D liquid cell culture method for anchorage-independent cell growth, cell imaging and automated drug screening Scientific Reports 2018
cancer, neuroscience Nuclear myosin 1 activates p21 gene transcription in response to DNA damage through a chromatin-based mechanism Communications Biology 2020
cancer, virology Optimization-by-design of hepatotropic lipid nanoparticles targeting the sodium-taurocholate cotransporting polypeptide eLife 2019
cancer Panduratin A induces protective autophagy in melanoma via the AMPK and mTOR pathway Phytomedicine 2018
cancer, neuroscience, stem cells Per-and polyfluoroalkyl substances impact human spermatogenesis in a stem-cell-derived model Systems Biology in Reprod Med 2018
cancer, neuroscience, stem cells Phenotypic and functional characteristics of human Schwann cells as revealed by cell-based assays and RNA-seq Molecular Neurobiology 2018
cancer Plagioneurin B, a potent isolated compound induces apoptotic signalling pathways and cell cycle arrest in ovarian cancer cells Apoptosis 2018
cancer, neuroscience, stem cells PP2A inhibition sensitizes cancer stem cells to ABL tyrosine kinase inhibitors in BCR-ABL+ human leukemia Science Translational Med 2018
cancer, neuroscience Preclinical evaluation of a GFRA1 targeted antibody-drug conjugate in breast cancer Oncotarget 2018
  Pro-inflammatory cytokines enhance dilatation of bile canaliculi caused by cholestatic antibiotics Toxicology in Vitro 2019
cancer Protein kinase A activation inhibits DUX4 gene expression in myotubes from patients with facioscapulohumeral muscular dystrophy Journal of Biological Chemistry 2018
cancer, neuroscience, stem cells Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice Human Molecular Genetics 2018
  Ptr/CTL0175 is required for the efficient recovery of Chlamydia trachomatis from stress induced by gamma-interferon Frontiers in Microbiology 2019
cancer Pu-erh tea relaxes the thoracic aorta of rats by reducing intracellular calcium Front Pharmacol 2019
  Quercetin protect cigarette smoke extracts induced inflammation and apoptosis in RPE cells Artif Cells Nanomed Biotechnol 2019
cancer RBM17 controls apoptosis and proliferation to promote Glioma progression Biochem Biophys Res Commun 2018
cancer, neuroscience Real-time monitoring of DNA G-quadruplexes in living cells with a small-molecule fluorescent probe Nucleic Acids Research 2018
cancer, neuroscience, stem cells, organoids Recent Advances in Microfluidic Techniques for Systems Biology Analytical Chemistry 2018
cancer Regulation of PRMT5–MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma PNAS 2019
cancer, neuroscience, stem cells Repression of somatic genes by selective recruitment of HDAC3 by BLIMP1 is essential for mouse primordial germ cell fate determination Cell Reports 2018
cancer, neuroscience Reversine inhibits colon carcinoma cell migration by targeting JNK1 Scientific Reports 2018
cancer Role of miR‑449b‑3p in endometriosis via effects on endometrial stromal cell proliferation and angiogenesis Molecular Medicine Reports 2018
cancer, neuroscience RPEL-family rhoGAPs link Rac/Cdc42 GTP loading to G-actin availability Nature Cell Biology 2019
cancer, neuroscience Severe PATCHED1 deficiency in cancer-prone Gorlin patient cells results in intrinsic radiosensitivity Int J Radiat Oncol Biol Phys 2018
cancer, neuroscience Soluble laminin polymers enhance axon growth of primary neurons in vitro Journal of Biomedical Chemistry 2018
neuroscience Specific Knockdown of α-Synuclein by Peptide-Directed Proteasome Degradation Rescued Its Associated Neurotoxicity Cell Chemical 2020
cancer Spontaneous Extracellular Matrix Accumulation in a Human in vitro Model of Renal Fibrosis Is Mediated by αV Integrins Nephron 2019
cancer Stable Redox-Cycling Nitroxide Tempol Has Antifungal and Immune-Modulatory Properties Frontiers in Microbiology 2019
cancer Staphylococcus aureus induces DNA damage in host cell Scientific Reports 2019
cancer, neuroscience Structural analysis and cellular visualization of APP RNA G-quadruplex Chemical Science 2019
stem cells Suppression of adipocyte differentiation by low‐intensity pulsed ultrasound via inhibition of insulin signaling and promotion of CCN family protein 2 Journal of Cellular Biochem 2020
cancer Suppression of CCT3 inhibits malignant proliferation of human papillary thyroid carcinoma cell Oncology Letters 2018
cancer Synthesis and evaluation of 1, 3, 4-oxadiazole derivatives for development as broad-spectrum antibiotics Bioorganic & Medicinal Chem 2019
cancer, neuroscience Synthetic probe development for measuring single or few-cell activity and efflux Methods in Enzymology 2019
  Systems toxicology assessment of a representative e-liquid formulation using human primary bronchial epithelial cells Toxicology Reports 2020
neuroscience, stem cells, organoids Testing for developmental neurotoxicity using a battery of in vitro assays for key cellular events in neurodevelopment Toxicology and Applied Pharmcol 2018
cancer TFIIA transcriptional activity is controlled by a 'cleave-and-run'Exportin-1/Taspase 1-switch Journal of Molecular Cell Bio 2018
cancer TGFβ promotes genomic instability after loss of RUNX3 Cancer Research 2018
stem cells thalidomide inhibits Human ipSc Mesendoderm Differentiation by Modulating cRBn-dependent Degradation of SALL4 Scientific Reports 2020
cancer, neuroscience, stem cells The AMPK/p27Kip1 axis regulates autophagy/apoptosis decisions in aged skeletal muscle stem cells Stem Cell Reports 2018
cancer The antimalarial drug mefloquine enhances TP53 premature termination codon readthrough by aminoglycoside G418 PloS One 2019
cancer, neuroscience The biological effects of long-term exposure of human bronchial epithelial cells to total particulate matter from a candidate modified-risk tobacco product Toxicology in Vitro 2018
cancer, stem cells The Cdkn1aSUPER Mouse as a Tool to Study p53-Mediated Tumor Suppression Cell Reports 2018
cancer, neuroscience, stem cells The dynamics of TGF-β signaling are dictated by receptor trafficking via the ESCRT machinery Cell Reports 2018
cancer, neuroscience The effect of Jun dimerization on neurite outgrowth and motif binding Molecular and Cellular Neuroscience 2018
cancer The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma Oncogene 2018
cancer The lead optimization of the polyamine conjugate of flavonoid with a naphthalene motif: Synthesis and biological evaluation European Journal of Med Chem 2018
cancer, neuroscience The relative composition of actin isoforms regulates cell surface biophysical features and cellular behaviors Biochimica et Biophysica  2018
  The secreted protein kinase CstK from Coxiella burnetii influences vacuole development and interacts with the GTPase-activating host protein TBC1D5 Journal of Biological Chemistry 2020
cancer The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells Bioorganic & Medicinal  Chemistry 2019
neuroscience, stem cells Tilianin mediates neuroprotection against ischemic injury by attenuating CaMKII-dependent mitochondrion-mediated apoptosis and MAPK/NF-κB signaling Life Sciences 2019
cancer, neuroscience, stem cells Tools to measure cell health and cytotoxicity using high content imaging and analysis Methods Mol Biol 2018
neuroscience, stem cells Transcriptomically Guided Mesendoderm Induction of Human Pluripotent Stem Cells Using a Systematically Defined Culture Scheme Stem Cell Reports 2019
virology Transmission of Cricket paralysis virus via exosome-like vesicles during infection of Drosophila cells Scientific Reports 2018
neuroscience Triclosan Affects Ca2+ Regulatory Module and Musculature Development in Skeletal Myocyte during Early Life Stages of Zebrafish (Danio rerio) Environmental Science & Technology 2019
cancer UBE2S promotes the proliferation and survival of human lung adenocarcinoma cells BMB reports 2018
cancer, neuroscience UBQLN4 represses homologous recombination and is overexpressed in aggressive tumors Cell 2019
neuroscience Unconventional secretion factor GRASP55 is increased by pharmacological unfolded protein response inducers in neurons Scientific Reports 2019
cancer, neuroscience Vitegnoside Mitigates Neuronal Injury, Mitochondrial Apoptosis, and Inflammation in an Alzheimer's Disease Cell Model via the p38 MAPK/JNK Pathway Journal of Alzheimer's Dis 2019
cancer Wee1 inhibitor AZD1775 effectively inhibits the malignant phenotypes of esophageal squamous cell carcinoma in vitro and in vivo Frontiers in Pharmacol 2019
cancer YAP1 is an independent prognostic marker in pancreatic cancer and associated with extracellular matrix remodeling Journal of Transl Med 2020
cancer, stem cells YES1 is a targetable oncogene in cancers harboring YES1 gene amplification Cancer Research 2019
cancer, neuroscience, stem cells β-Actin–dependent global chromatin organization and gene expression programs control cellular identity The FASEB Journal 2018